肝癌分子诊断标志物及相关组学技术研究进展

Advances in Molecular Diagnostic Markers and Related Omics Techniques for Liver Cancer

摘要: 肝癌具有高度侵袭性和复发率，是我国常见恶性肿瘤之一。由于肝癌早期症状很不明显，早期诊断又比较困难，因此具有很高的致死率。早期诊断是预防肝癌、提高肝癌患者生存率最重要的措施之一，筛选和鉴定肝癌的早期诊断标志物是首要任务，利于相关组学研究技术来探寻新的诊疗方法刻不容缓，通过寻找新的特异性肝癌分子标志物，以建立更全面更有效的分子分型分层系统，通过早期诊断提高肝癌患者的生存率。本文对传统的、潜在的肝癌早期诊断标志物及其检测方法的研究进展作一综述。

Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China with high invasive and recurrence rate. Because the early symptoms of liver cancer are not obvious and the early diagnosis is difficult, it has a high mortality rate. Early diagnosis is one of the most important measures to prevent liver cancer and improve the survival rate of patients with liver cancer. Screening and early diagnosis markers for the identification of cancer of the liver are the primary task. It is urgent to explore new methods of diagnosis and treatment with the help of related omics research techniques, by finding new specific molecular markers of liver cancer, to establish a more comprehensive and more effective molecular classification layered system, and improve survival of patients with liver cancer by early diagnosis. This paper reviews the research progress of traditional and potential markers for early diagnosis of liver cancer and their detection methods.