半乳糖修饰组氨酸壳聚糖衍生物靶向给药系统研究
The Study on the Drug Delivery of Galactosylated Histidine Chitosan Nanoparticles
DOI: 10.12677/MS.2019.91013, PDF,   
作者: 苗淑杰:复旦大学生命科学学院遗传学和遗传工程系,上海
关键词: 壳聚糖组氨酸半乳糖siRNA递送Chitosan Histidine Galactose siRNA Delivery
摘要: 本文以半乳糖基化壳聚糖–组氨酸衍生物经离子交联法包载VEGF干扰RNA (siRNA)制备纳米粒(NP),研究其理化性质,体外释放特性及细胞毒性,研究表明功能基团修饰NP递送载体稳定性好、细胞毒性低,有望应用于基因药物递送。
Abstract: Galactose modified chitosan-histidine conjugate (GCH) was developed in this study as cationic vector for the delivery of vascular endothelial growth factor (VEGF) siRNA (siVEGF). The physicochemical properties, profile of siRNA release and cytotoxicity of copolymers were characterized. The nanoparticles were proved to be stable with low cytotoxicity and expected to be applied to gene drug delivery.
文章引用:苗淑杰. 半乳糖修饰组氨酸壳聚糖衍生物靶向给药系统研究[J]. 材料科学, 2019, 9(1): 93-103. https://doi.org/10.12677/MS.2019.91013

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