大麻二酚的生物学功效与制备研究
A Study Review of the Biological Effect and Preparation of Cannabidiol
DOI: 10.12677/BR.2019.83025, PDF,    科研立项经费支持
作者: 韩宗博, 常秀莲：烟台大学生命科学学院，山东 烟台；戚克进：烟台正材环保科技有限公司，山东 烟台；王少峰：漳州金三角生物科技有限公司，福建 漳州
关键词: 大麻二酚；制备方法；提取；研究进展；Cannabidiol； Preparation； Extract； Research Progress
摘要: 大麻二酚是药用植物大麻中的主要化学成分，具有重要的医学应用价值。近几年，欧美国家对于大麻二酚的应用处于领先地位，而我国对于大麻二酚的重视还远远不够。根据现有的关于大麻二酚的专利与技术，详细介绍了大麻二酚的制备与纯化的方法，包括植物提取法和化学合成法，并分析每种方法的优劣势，同时列出并比较了大麻二酚的检测方法。
Abstract: Cannabidiol is the main chemical component of medicinal plant cannabis, and has great medical and application values. In recent years, Europe and the United States have taken the lead in the application of cannabidiol; however, China's emphasis on cannabidiol is far from enough. Based on the existing patents and technologies for cannabidiol, the method for preparing and purifying cannabidiol is described in detail herein, including extraction method from plant and chemical synthesis method, and the advantages and disadvantages of each method are analyzed. The mea-surement methods of cannabidiol are listed for comparison at the same time.
文章引用：韩宗博, 戚克进, 王少峰, 常秀莲. 大麻二酚的生物学功效与制备研究[J]. 植物学研究, 2019, 8(3): 190-195. https://doi.org/10.12677/BR.2019.83025

参考文献

[1] 王静. “大麻”应用相关专利初探[N]. 中国知识产权报, 2014-05-23.
[2] Girgih, A.T., Udenigwe, C.C. and Aluko, R.E. (2011) In Vitro Antioxidant Properties of Hemp Seed (Cannabis sativa L.) Protein Hydrolysate Fractions. Journal of the American Oil Chemists’s Society, 88, 381-389. [Google Scholar] [CrossRef] 
[3] Callaway, J.C. (2004) Hempseed as a Nutritional Resources: An Overview. Euphytica, 140, 65-72. [Google Scholar] [CrossRef] 
[4] Massi, P., Solinas, M., Cinquina, V. and Parolaro, D. (2012) Cannabidiol as Potential Anticancer Drug. British Journal of Clinical Pharmacology, 75, 303-312. [Google Scholar] [CrossRef] [PubMed]
[5] Mechoulam, R., Peters, M., Rodriguez, E. and Hanuš, L.O. (2007) Cannabidiol—Recent Advance. Chemistry and Biodiversity, 4, 1678-1692. [Google Scholar] [CrossRef] [PubMed]
[6] 马因. 大麻二酚可阻断乳腺癌转移[J]. 中华中医药学刊, 2008(1): 56.
[7] Mintz, C.S., Nison, E. and Fabrizio, A.J. (2015) Cannabis-Derived Pharmaceuticals. Journal of Commercial Biotechnology, 21, 16-31. [Google Scholar] [CrossRef] 
[8] 成亮, 吕峰, 孔德云, 等. 大麻二酚抗风湿性类关节炎作用研究[J]. 世界临床医药, 2013, 34(9): 527-530.
[9] 殷莎, 唐双奇, 陆阳. 大麻二酚神经保护作用机制研究进展[J]. 中草药, 2014, 45(3): 432-436.
[10] Iuvone, T., Esposito, G., De Filippis, D., Scuderi, C. and Steardo, L. (2010) Cannabidiol: A Promising Drug for Neurodegenerative Disorders? CNS Neuroscience & Therapeutics, 15, 65-75. [Google Scholar] [CrossRef] [PubMed]
[11] 成亮, 孔德云. 大麻中非成瘾性成分大麻二酚及其类似物的研究概况[J]. 中草药, 2008, 39(5): 783-787.
[12] Grotenhermen, F. (2004) Clinical Pharmacodynamics of Cannabinoids. Journal of Cannabis Therapeutics, 4, 29-78. [Google Scholar] [CrossRef] 
[13] Yamamoto, I., Watanabe, K., Matsunaga, T., Kimura, T., Funahashi, T. and Yoshimura, H. (2003) Pharmacology and Toxicology of Major Constituents of Marijuana on the Metabolic Activation of Cannabinoids and Its Mechanism. Journal of Toxicology: Toxin Reviews, 22, 577-589. [Google Scholar] [CrossRef] 
[14] 弓佩含, 杨洋, 刘玉婷, 等. 大麻化学成分及药理作用的研究进展[J]. 中国实验方剂学杂志, 2017, 23(13): 212-219.
[15] Simmerman, E., Xu, Q., Yu, J.C. and Baban, B. (2019) Cannabinoids as a Potential New and Novel Treatment for Melanoma: A Pilot Study in a Murine Model. Journal of Surgical Research, 235, 210-215. [Google Scholar] [CrossRef] [PubMed]
[16] Shbiro, L., Hen-Shoval, D., Hazut, N., Rapps, K., Dar, S., Zalsman, G., Mechoulam, R., Weller, A. and Shoval, G. (2019) Effects of Cannabidiol in Males and Females in Two Different Rat Models of Depression. Physiology & Behavior, 201, 59-63. [Google Scholar] [CrossRef] [PubMed]
[17] 张晓京, 马丽娟. 用气相色谱法分析大麻籽油中的Δ9-四氢大麻酚[J]. 宁夏大学学报(自然版), 2004, 25(3): 253-254.
[18] 张岗, 郭江宁, 毕开顺. 高效液相色谱法测定火麻仁油中Δ9-四氢大麻酚的含量[J]. 沈阳药科大学学报, 2003, 20(4): 269-271.
[19] 辛荣昆. 从工业大麻中提取二氢大麻酚工艺[P]. 中国专利, 103739585. 2014-04-23.
[20] 云南汉素生物科技有限公司. 一种大麻二酚的提取方法[P]. 中国专利, 106831353. 2017-06-13.
[21] 云南汉木森生物科技有限责任公司. 一种富集大麻二酚的方法[P]. 中国专利, 107011125. 2017-08-04.
[22] 吴俊锋, 杨晓泉. 酶辅助溶剂法提取火麻叶中大麻二酚工艺条件的优化[J]. 中国酿造, 2016, 35(4): 79-82.
[23] Gutman, A.L., Nisnevich, G.A., Rukhman, I., et al. (2006) Methods for Purifying Trans-(−)-Δ9-Tetrahydrocannabinol and Trans-(+)-Δ9-Tetrahydrocannabinol. US Patent No. 2006053766A8.
[24] Stinchcomb, A.L., GolinskiM, J., Hammel, F.C., et al. (2009) Prodrugs of Cannabidiol, Compositions Comprising Prodrugs of Cannabidiol and Methods of Using the Same. US Patent No. 20090036523.
[25] Steup, C. and Herkenroth, T. (2010) Process for Preparing Synthetic Cannabinoids. US Patent No. 20100298579.