预测性生物标记物在急性移植物抗宿主病中的研究进展
Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation
DOI: 10.12677/MD.2019.92014, PDF,    科研立项经费支持
作者: 徐艳军*：南方医科大学附属佛山妇幼保健院儿科，广东 佛山；易甜甜, 吴学东：南方医科大学南方医院儿科，广东 广州
关键词: 异基因造血干细胞移植；急性移植物抗宿主病；生物标记物；Allogeneic Hematopoietic Stem Cell Transplantation； Acute Graft-versus-Host Disease； Biomarkers
摘要: 急性移植物抗宿主病是异基因造血干细胞移植后不可避免遇到的棘手问题，临床上主要依靠临床表现及病理活检进行诊断。预测性生物标记物成为近年来研究热点，多中心共同研究成为必然趋势，本文对近年来国内外预测性生物标记物的研究进行总结归纳，主要包括对基因、蛋白质及细胞水平的研究。
Abstract: Acute graft-versus-host disease (aGVHD) is the primary source of morbidity and mortality after HSCT. Diagnosis of aGVHD is typically based on clinical symptoms and confirmed by biopsy. In this review, we aim to summarize some of the recent developments of biomarkers in the field of al-lo-HSCT, including miRNAs, Cellular biomarkers, Proteomic biomarkers and biomarker panels. At present, the research of biomarkers has become a hotspot. However, predictive biomarkers still require a coordinated multicenter approach with coordinated times of sampling and centralized analysis of biomarker levels.
文章引用：徐艳军, 易甜甜, 吴学东. 预测性生物标记物在急性移植物抗宿主病中的研究进展[J]. 医学诊断, 2019, 9(2): 71-76. https://doi.org/10.12677/MD.2019.92014

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