细菌羊毛硫抗生素研究进展
Advances in Bacterial Lantibiotics
摘要: 羊毛硫抗生素(lantibiotics)是指由细菌产生的，通过核糖体途径合成的翻译后修饰的具有特殊有机基团的一类抗菌肽，或称硫醚抗生素。羊毛硫抗生素由革兰氏阳性菌产生，可以明显抑制微生物的生长，尤其是抑制革兰氏阳性菌。传统抗生素的过量使用导致病原菌抗药性的现象普遍发生，羊毛硫抗生素对于改变这一现状具有很大的开发潜力。本文根据羊毛硫抗生素的作用机制与产品开发研究现状，对羊毛硫抗生素的发现、分类、作用机制、产业化进程及未来的展望逐一介绍。
Abstract: Lantibiotics is a class of antimicrobial peptides, or thioether antibiotics produced by bacteria that are synthesized by the ribosomal pathway and has a special organic group. Lantibiotics is produced by Gram-positive bacteria, and can significantly inhibit the growth of microorganisms, especially Gram-positive bacteria. Excessive use of traditional antibiotics leads to the widespread occurrence of pathogen resistance, lantibiotics has great potential for changing this situation. This study is based on the mechanism of action and product development of lantibiotics, to introduce the introduction, classification, mechanism of action, industrialization process and future prospects of lantibiotics one by one.
文章引用：周华飞, 杨红福, 束兆林, 陈宏州, 姚克兵. 细菌羊毛硫抗生素研究进展[J]. 微生物前沿, 2019, 8(3): 145-153. https://doi.org/10.12677/AMB.2019.83018

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