蒽酮及其衍生物的合成研究

Synthesis of Anthrone and Its Derivatives

摘要: 蒽酮及其衍生物在化学分析及药物合成中有着不可或缺的地位，传统方法通过锡或氯化亚锡还原蒽醌类化合物制备蒽酮及其衍生物。本文探索了一种由铁粉为还原剂还原羰基制备蒽酮及其衍生物大黄素蒽酮、地蒽酚的方法，收率达到85%~95%，其结构经1H NMR、MS分析鉴定确证为蒽酮、大黄素酮、地蒽酚。

Abstract: Anthrone and its derivatives play an indispensable role in the field of chemical analysis and medi-cine synthesis, usually prepared by reducing anthraquinone compounds with tin or stannous chloride. In this paper, a method of preparing anthrone and its derivatives, emodin anthrone and anthralin, by reducing carbonyl group with iron powder as reducing agent, was explored, the yield reached 85%~95%, and the structure was identified as anthrone, emodin and anthralin by 1HNMR and MS.