驱动蛋白14基因及其与子宫颈癌研究进展

Research Progress on Kinesin 14 Gene andCervical Cancer

摘要: KIF14是用水解ATP的能量将细胞中的颗粒、囊泡等物质在微管上移动的，由1648个氨基酸残基组成的驱动蛋白，在细胞器运输，有丝分裂，轴突运输，精子运输和细胞迁移等细胞生命代谢过程中有重要作用，参与癌细胞的分裂，增殖和迁移等过程。KIF14表达失调与癌症的发展、侵袭和转移有关。KIF14具有丰富的功能活性，研究发现宫颈癌患者KIF14表达失调并与微管蛋白抑制剂的临床疗效有关。KIF14驱动蛋白研究虽然取得一些进展，但是与临床应用还有相当的距离。KIF14在子宫颈癌中扮演着什么样的角色，其对子宫颈癌的早期诊断，临床分型及其与疗效的关联性等许多问题还没有得到很好的诠释，精确地解答这些问题，对提高宫颈癌的诊治效果有重要作用。

Abstract: Kif14 uses the energy of ATP hydrolysis to move particles, vesicles and other substances in cells on microtubules. It is a driver protein composed of 1648 amino acid residues, which is transported in Organelles, Mitosis, and axonal transport, sperm Transport and cell migration play an important role in cell metabolism and participate in the process of Cancer Cell Division, Proliferation and Migration. Kif14 expression disorder is associated with the development, invasion and metastasis of cancer. Kif14 has rich functional activity. It was found that the imbalance of KIF14 expression in cervical cancer patients is related to the clinical efficacy of Tubulin inhibitors. Although some progress has been made in the study of KIF14 driver protein, it is still far from clinical application. What role does KIF14 play in cervical cancer, its role in the early diagnosis of cervical cancer, clinical classification and its relationship with curative effect, and many other issues have not been well interpreted to precisely answer these questions, it plays an important role in improving the diagnosis and treatment of cervical cancer.