ACM  >> Vol. 10 No. 3 (March 2020)

    儿童青少年非酒精性脂肪肝病的发病机制
    Pathogenesis of Nonalcoholic Fatty Liver Disease in Children and Adolescents

  • 全文下载: PDF(417KB)    PP.360-366   DOI: 10.12677/ACM.2020.103057  
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作者:  

郑朝安:浙江大学医学院,浙江 杭州;
傅君芬:浙江大学医学院附属儿童医院内分泌科,浙江 杭州

关键词:
儿童青少年非酒精性脂肪性肝炎非酒精性脂肪性肝病发病机制Children Adolescents Non-Alcoholic Steatohepatitis Nonalcoholic Fatty Liver Disease Pathogenesis

摘要:

随着全球肥胖发病率的上升,非酒精性脂肪性肝病(Nonalcoholic fatty liver disease, NAFLD)已经成为儿童及青少年慢性肝病的主要表现。NAFLD代表一个广泛的疾病谱,包括非酒精性单纯性脂肪肝(nonalcoholic fatty liver, NAFL)、非酒精性脂肪性肝炎(non-alcoholic steatohepatitis, NASH)、肝硬化及肝癌。虽然目前普遍认为NAFLD与肥胖以及胰岛素抵抗密切相关,但其具体的发病机制尚未明确。在本文中,我们将对儿童青少年非酒精性脂肪性肝病的发病机制进行综述。

Nonalcoholic fatty liver disease (NAFLD) has become the main manifestation of chronic liver disease in children and adolescents with the increasing incidence of obesity worldwide. NAFLD represents a broad spectrum of diseases, including nonalcoholic fatty liver, non-alcoholic steatohepatitis (NASH), cirrhosis and liver carcinoma. Although it is generally believed that NAFLD is closely related to obe-sity and insulin resistance, the specific pathogenesis of NAFLD remains unclear. In this article, we will review the pathogenesis of nonalcoholic fatty liver disease in children and adolescents.

文章引用:
郑朝安, 傅君芬. 儿童青少年非酒精性脂肪肝病的发病机制[J]. 临床医学进展, 2020, 10(3): 360-366. https://doi.org/10.12677/ACM.2020.103057

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