亚磷酸酯催化的亚胺与丙烯酸甲酯的氮杂Baylis-Hillman反应研究
Phosphite Catalyzed Aza-Baylis-Hillman Reaction of Imines and Methyl Acrylates
DOI: 10.12677/SSC.2020.81004, PDF,    国家自然科学基金支持
作者: 贾 俊：苏州大学，分析测试中心，江苏 苏州；姚其波, 陶京朝：郑州大学，化学学院，河南 郑州；王兴旺*：苏州大学，材料与化学化工学部，江苏 苏州
关键词: 氮杂Baylis-Hillman反应；亚磷酸酯；亚胺；丙烯酸甲酯；α-亚甲基β-磺酰胺基丙烯酸酯；aza-Bayllis-Hillman Reaction； Phosphite； Imine； Methyl Acrylates； α-Methylene--Sulfonamido Acrylates
摘要: 本文以一系列亚磷酸酯为催化剂，对催化芳香醛亚胺与丙烯酸甲酯的氮杂Baylis-Hillman反应进行了系统研究。经过对该反应的溶剂、反应温度、底物浓度、催化剂进行了筛选和优化，我们发现亚磷酸二乙酯和1,4-二氮杂二环[2.2.2]辛烷(DABCO)能有效催化该反应。最后对一系列底物进行测试，所有反应能以中等到良好的收率得到α-亚甲基β-磺酰胺基丙烯酸酯产物。
Abstract: The aza-Bayllis-Hillman reactions of imines and methyl acrylate catalyzed by achiral phosphite were studied. The reaction conditions, such as solvent, temperature, concentration, catalysts, and substrates were screened. The target products of α-methylene--sulfonamido acrylates were obtained with 25% - 78% yield.
文章引用：贾俊, 姚其波, 陶京朝, 王兴旺. 亚磷酸酯催化的亚胺与丙烯酸甲酯的氮杂Baylis-Hillman反应研究[J]. 合成化学研究, 2020, 8(1): 33-41. https://doi.org/10.12677/SSC.2020.81004

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