尿酸和疾病的关系研究进展
Research Progress of the Relationship between Uric Acid and Disease
DOI: 10.12677/BP.2020.103004, PDF,   
作者: 刘 璐, 宫 婷*:中国人民解放军第971医院,山东 青岛
关键词: 尿酸疾病综述Uric Acid Disease Review
摘要: 尿酸是嘌呤代谢的终产物,血浓度超过一定阈值会导致躯体疼痛、功能受损。目前认为高尿酸血症与心血管疾病、代谢综合征、卒中、肾脏疾病等密切相关,然而尿酸与各类疾病的关系、尿酸是否是这些疾病的独立危险因素的结论尚未达成共识。本文就尿酸与心血管疾病、肾脏疾病、癌症、糖尿病、神经系统疾病的关系进行综述。
Abstract: Uric acid is the end product of purine metabolism. It will cause physical pain and impaired function when the blood concentration exceeds a certain threshold. It is acknowledged that hyperuricemia is related to cardiovascular disease, metabolic syndrome, stroke and kidney disease. However, there is no consensus on the relationship between uric acid and different diseases and whether uric acid is an independent risk factor of these diseases. This article reviews the relationship between uric acid and cardiovascular disease, kidney disease, cancer, diabetes, and nervous system disease.
文章引用:刘璐, 宫婷. 尿酸和疾病的关系研究进展[J]. 生物过程, 2020, 10(3): 20-26. https://doi.org/10.12677/BP.2020.103004

参考文献

[1] Riches, P.L., Wright, A.F. and Ralston, S.H. (2009) Recent Insights into the Pathogenesis of Hyperuricaemia and Gout. Human Molecular Genetics, 18, 177-184. [Google Scholar] [CrossRef] [PubMed]
[2] 高尿酸血症相关疾病诊疗多学科共识专家组. 中国高尿酸血症相关疾病诊疗多学科专家共识[J]. 中华内科杂志, 2017, 56(3): 235-248.
[3] 王丹晨, 尹逸丛, 邱玲, 等. 中国人群血清尿酸与高血压相关[J]. 基础医学与临床, 2019, 39(2): 182-186.
[4] Ames, B.N., Cathcart, R., Schwiers, E., et al. (1981) Uric Acid Provides an Antioxidant Defense in Hu-mans against Oxidant- and Radical-Caused Aging and Cancer: A Hypothesis. Proceedings of the National Academy of Sciences of the United States of America, 78, 6858-6862. [Google Scholar] [CrossRef] [PubMed]
[5] Delasierra, A. (1995) Changes in Fluid, Ionic, Metabolic, and Hormonal Parameters Induced by High Salt Intake in Salt-Sensitive and Salt-Resistant Hypertensive Patients. American Journal of Hypertension, 8, 160A. [Google Scholar] [CrossRef
[6] Fathallah-Shaykh, S.A. and Cramer, M.T. (2014) Uric Acid and the Kidney. Pediatric Nephrology, 29, 999-1008. [Google Scholar] [CrossRef] [PubMed]
[7] Kuwabara, M., Niwa, K., Ohtahara, A., et al. (2017) Prevalence and Complications of Hypouricemia in a General Population: A Large-Scale Cross-Sectional Study in Japan. PLoS ONE, 12, e0176055. [Google Scholar] [CrossRef] [PubMed]
[8] 曲桂红, 孙志芬, 刘秀菊. 259例低尿酸血症患者的血清尿酸浓度降低的原因及临床意义[J]. 心理月刊, 2019, 14(12): 178.
[9] Jossa, F., Farinaro, E., Panico, S., et al. (1994) Serum Uric Acid and Hypertension: The Olivetti Heart Study. Journal of Human Hypertension, 8, 677-681.
[10] 薛桂君, 卢梦婕, 何礼霞, 等. 2011-2014年体检者血压水平与血清尿酸水平的关系[J]. 现代生物医学进展, 2016, 16(11), 2157-2158.
[11] Culleton, B.F., Larson, M.G., Kannel, W.B., et al. (1999) Serum Uric Acid and Risk for Car-diovascular Disease and Death: The Framingham Heart Study. Annals of Internal Medicine, 131, 7-13. [Google Scholar] [CrossRef] [PubMed]
[12] Tseng, W.C., Chen, Y.T., Ou, S.M., et al. (2018) U-Shaped Association between Serum Uric Acid Levels with Cardiovascular and All-Cause Mortality in the Elderly: The Role of Malnourishment. Journal of the American Heart Association, 7, e007523. [Google Scholar] [CrossRef
[13] Kanellis, J., Watanabe, S., Li, J.H., et al. (2003) Uric Acid Stimu-lates Monocyte Chemoattractant Protein-1 Production in Vascular Smooth Muscle Cells via Mitogen-Activated Protein Kinase and Cyclooxygenase-2. Hypertension, 41, 1287-1293. [Google Scholar] [CrossRef
[14] Neogi, T., Ellison, R.C., Hunt, S., et al. (2009) Serum Uric Acid Is Associated with Carotid Plaques: The National Heart, Lung, and Blood Institute Family Heart Study. Jour-nal of Rheumatology, 36, 378-384. [Google Scholar] [CrossRef] [PubMed]
[15] Xu, W., Huang, Y., Li, L., et al. (2016) Hyperuricemia Induces Hy-pertension through Activation of Renal Epithelial Sodium Channel (ENaC). Metabolism—Clinical and Experimental, 65, 73-83. [Google Scholar] [CrossRef] [PubMed]
[16] 李俊, 孙承谋, 施蓉. 急性冠脉综合征患者血尿酸水平与机体炎性反应及血管内皮功能关系分析[J]. 国际检验医学杂志, 2019, 40(4): 498-500.
[17] 汪洋, 陈晨, 褚超, 等. 慢性盐负荷对成年人血尿酸及尿尿酸水平的影响[J]. 中国医刊, 2019, 54(4): 368-371.
[18] Richette, P. and Bardin, T. (2010) Gout. The Lancet, 375, 318-328. [Google Scholar] [CrossRef
[19] 王彩霞, 刘迅, 李少敏, 等. 慢性肾病患者中营养水平对尿酸水平与实测肾小球滤过率之间关系的影响[J]. 新医学, 2017, 48(4): 239-244.
[20] Kanda, E., Muneyuki, T., Kanno, Y., et al. (2015) Uric Acid Level Has a U-Shaped Association with Loss of Kidney Function in Healthy People: A Prospective Cohort Study. PLOS ONE, 10, e0118031. [Google Scholar] [CrossRef] [PubMed]
[21] Jiang, M.Y., Hwang, J.C., Lu, Y.H., et al. (2015) Clinical Im-plications and Outcome Prediction in Chronic Hemodialysis Patients with Lower Serum Potassium × Uric Acid Product. European Journal of Internal Medicine, 26, 646-651. [Google Scholar] [CrossRef] [PubMed]
[22] Bae, E., Cho, H.J., Shin, N., et al. (2016) Lower Serum Uric Acid Level Predicts Mortality in Dialysis Patients. Medicine (United States), 95, 1-9. [Google Scholar] [CrossRef
[23] Park, C., Obi, Y., Streja, E., et al. (2017) Serum Uric Acid, Protein Intake and Mortality in Hemodialysis Patients. Nephrology Dialysis Transplantation, 32, 1750-1757. [Google Scholar] [CrossRef] [PubMed]
[24] Xu, X., Hu, J., Song, N., et al. (2017) Hyperuricemia Increases the Risk of Acute Kidney Injury: A Systematic Review and Meta-Analysis. BMC Nephrology, 18, Article No. 27. [Google Scholar] [CrossRef] [PubMed]
[25] Petersson, B.O., Trell, E, Henningsen, N., et al. (1984) Risk Fac-tors for Premature Death in Middle Aged Men. British Medical Journal, 288, 1264-1268. [Google Scholar] [CrossRef] [PubMed]
[26] Levine, W., Dyer, A.R., Shekelle, R.B., et al. (1989) Serum Uric Acid and 11.5-Year Mortality of Middle-Aged Women: Findings of the Chicago Heart Association Detection Project in Industry. Journal of Clinical Epidemiology, 42, 257-267. [Google Scholar] [CrossRef] [PubMed]
[27] Strasak, A.M., Rapp, K., Hilbe, W., et al. (2007) Serum Uric Acid and Risk of Cancer Mortality in a Large Prospective Male Cohort. Cancer Causes & Control, 18, 1021-1029. [Google Scholar] [CrossRef] [PubMed]
[28] Strasak, A.M., Lang, S., Kneib, T., et al. (2009) Use of Penalized Splines in Extended Cox-Type Additive Hazard Regression to Flexibly Estimate the Effect of Time-Varying Serum Uric Acid on Risk of Cancer Incidence: A Prospective, Population-Based Study in 78,850 Men. Annals of Epidemiology, 19, 15-24. http://www.sciencedirect.com/science/article/pii/S1047279708001695 [Google Scholar] [CrossRef] [PubMed]
[29] Boffetta, P., Nordenvall, C., Nyren, O., et al. (2009) A Pro-spective Study of Gout and Cancer. European Journal of Cancer Prevention: The Official Journal of the European Can-cer Prevention Organisation (ECP), 18, 127-132. [Google Scholar] [CrossRef
[30] 蒋传林, 田山, 董卫国. 高尿酸血症与胃癌预后关系的研究[J]. 实用癌症杂志, 2019(2): 207-210.
[31] Fini, M.A., Elias, A., Johnson, R.J., et al. (2012) Contribution of Uric Acid to Cancer Risk, Recurrence, and Mortality. Clinical and Translational Medicine, 1, 16. [Google Scholar] [CrossRef] [PubMed]
[32] Sluijs, I., Holmes, M.V.,Van Der Schouw, Y.T., et al. (2015) A Mendelian Randomization Study of Circulating Uric Acid and Type 2 Diabetes. Diabetes, 64, 3028-3036. [Google Scholar] [CrossRef] [PubMed]
[33] Li, X., Meng, X., Gao, X., et al. (2018) Elevated Serum Xanthine Oxidase Activity Is Associated with the Development of Type 2 Diabetes: A Prospective Cohort Study. Diabetes Care, 41, 884-890. http://care.diabetesjournals.org/content/41/4/884.abstract [Google Scholar] [CrossRef] [PubMed]
[34] Herman, J. and Goldbourt, U. (1982) Uric Acid and Diabetes: Observa-tions in a Population Study. The Lancet, 320, 240-243. http://www.sciencedirect.com/science/article/pii/S0140673682903245 [Google Scholar] [CrossRef
[35] Nakanishi, N., Okamoto, M., Yoshida, H., et al. (2003) Se-rum Uric Acid and Risk for Development of Hypertension and Impaired Fasting Glucose or Type II Diabetes in Japanese Male Office Workers. European Journal of Epidemiology, 18, 523-530. [Google Scholar] [CrossRef
[36] Daudon, M., Traxer, O., Conort, P., et al. (2006) Type 2 Diabetes Increases the Risk for Uric Acid Stones. Journal of the American Society of Nephrology, 17, 2026-2033. [Google Scholar] [CrossRef
[37] Dehghan, A., Van Hoek, M., Sijbrands, E.J.G., et al. (2008) High Serum Uric Acid as a Novel Risk Factor for Type 2 Diabetes. Diabetes Care, 31, 361-362. [Google Scholar] [CrossRef] [PubMed]
[38] Anothaisintawee, T., Lertrattananon, D., Thamakaison, S., et al. (2017) Di-rect and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis. Journal of Diabetes Research, 2017, Article ID: 6830671. [Google Scholar] [CrossRef] [PubMed]
[39] Lehto, S., Niskanen, L., Rönnemaa, T., et al. (1998) Serum Uric Acid Is a Strong Predictor of Stroke in Patients with Non-Insulin-Dependent Diabetes Mellitus. Stroke, 29, 635-639. [Google Scholar] [CrossRef
[40] Li, J., Muraki, I., Imano, H., et al. (2020) Serum Uric Acid and Risk of Stroke and Its Types: The Circulatory Risk in Communities Study (CIRCS). Hypertension Research, 43, 313-321. [Google Scholar] [CrossRef] [PubMed]
[41] Desideri, G., Gentile, R., Antonosante, A., et al. (2017) Uric Acid Amplifies Aβ Amyloid Effects Involved in the Cognitive Dysfunction/Dementia: Evidences from an Experimental Model in Vitro. Journal of Cellular Physiology, 232, 1069-1078. [Google Scholar] [CrossRef] [PubMed]
[42] Church, W. and Ward, V.L. (1994) Uric Acid Is Reduced in the Substantia Nigra in Parkinson’s Disease: Effect on Dopamine Oxidation. Brain Research Bulletin, 33, 419-425. [Google Scholar] [CrossRef] [PubMed]
[43] De Lau, L.M.L., Koudstaal, P.J., Hofman, A., et al. (2005) Serum Uric Acid Levels and the Risk of Parkinson Disease. Annals of Neu-rology, 58, 797-800. [Google Scholar] [CrossRef] [PubMed]
[44] Andreadou, E., Nikolaou, C., Gournaras, F., et al. (2009) Serum Uric Acid Levels in Patients with Parkinson’s Disease: Their Relationship to Treatment and Disease Dura-tion. Clinical Neurology and Neurosurgery, 111, 724-728. [Google Scholar] [CrossRef] [PubMed]