维生素A缺乏与儿童疾病关系的研究现状
Research Status of Relationship between Vitamin A Deficiency and Diseases in Children
DOI: 10.12677/ACM.2020.109311, PDF,   
作者: 吴贝贝, 姜 泓*：延安大学附属医院儿科，陕西 延安
关键词: Vit A缺乏；儿童疾病；研究现状；Vitamin A Deficiency； Children Diseases； Research Status
摘要: 维生素A缺乏症是目前一个严重且广泛的公共卫生问题，已经引起越来越多人的关注。从最初局限于夜盲症的认识，到目前发现与儿童的生长发育、反复感染、贫血等疾病同样密切相关。本文将从Vit A缺乏与儿童生长发育、感染性疾病、贫血、免疫系统、视力等疾病关系以及Vit A缺乏症的预防措施等方面进行综述。
Abstract: Vitamin A deficiency is a serious and widespread public health problem, which has attracted more and more attention. From initially limited to the understanding of night blindness, to the present found that it is also closely related to children’s growth and development, repeated infection, anemia and other diseases. This article will review the relationship between vitamin A deficiency and children’s growth and development, infectious diseases, anemia, immune system, vision and other diseases, as well as the prevention measures of vitamin A deficiency.
文章引用：吴贝贝, 姜泓. 维生素A缺乏与儿童疾病关系的研究现状[J]. 临床医学进展, 2020, 10(9): 2073-2078. https://doi.org/10.12677/ACM.2020.109311

参考文献

[1] 华天懿. 维生素A缺乏对儿童生长发育的影响及我国儿童维生素A营养现状[J]. 中国儿童保健杂志, 2005, 13(6): 519-521.
[2] Gilbert, C. (2001) Sight and Life Manual on Vitamin A Deficiency Disorders (VADD). Transactions of the Royal Society of Tropical Medicine and Hygiene, 95, 693. [Google Scholar] [CrossRef] 
[3] 李廷玉. 人体重要微量营养素研究进展[C]//重庆市营养学会, 四川省营养学会. 首届中国西部营养与健康、亚健康学术会议论文集. 重庆, 四川: 四川省营养学会、重庆市营养学会, 2005: 7.
[4] 张继国, 张兵, 杜文雯, 苏畅, 刘爱东, 张仅, 马玉霞, 翟凤英. 中国西部6省(区)贫困农村5岁以下儿童维生素A缺乏状况分析[J]. 中华流行病学杂志, 2011(12): 1224-1226.
[5] 谈藏文, 马官福, 林良明, 刘玉琳, 刘敏, 刘春燕, 王力. 边远地区儿童维生素A营养状况[J]. 中国儿童保健杂志, 2007, 15(1): 25-27.
[6] Emmett, S.D. and West, K.P. (2014) Gestational Vitamin A Deficiency: A Novel Cause of Sensorineural Hearing Loss in the Developing World? Medical Hypotheses, 82, 6-10. [Google Scholar] [CrossRef] [PubMed]
[7] Simkin, S.K., Tuck, K., Garrett, J., et al. (2016) Vitamin A Deficiency—An Unexpected Cause of Visual Loss. The Lancet, 387, 93-94. [Google Scholar] [CrossRef] 
[8] 李廷玉. 维生素A缺乏的诊断、治疗及预防[J]. 中华实用儿科临床杂志, 2013, 28(19): 1519-1520.
[9] World Health Organization (1996) Indicators for Assessing Vitamin A Deficiency and Their Application in Monitoring and Evaluating Intervention Programs. World Health Organization, Geneva.
[10] Sherwin, J.C., Reacher, M.H., Dean, W.H. and Ngondi, J. (2012) Epidemiology of Vitamin A Deficiency and Xerophthalmia in At-Risk Populations. Transactions of the Royal Society of Tropical Medicine and Hygiene, 106, 205-214. [Google Scholar] [CrossRef] [PubMed]
[11] West, K.P. (2003) Vitamin A Deficiency Disorders in Children and Women. Food and Nutrition Bulletin, 24, 78-90. [Google Scholar] [CrossRef] 
[12] Tienboon, P. and Wangpakapattanawong, P. (2007) Vitamin A Status of the Minority Ethnic Group of Karen Hill Tribe Children Aged 1-6 Years in Northern Thailand. Asia Pacific Journal of Clinical Nutrition, 16, 158-162.
[13] 杨晓光, 翟凤英. 中国居民营养与健康状况调查报告[M]. 北京: 人民卫生出版社, 2006.
[14] 杨帆, 李廷玉. 儿童维生素A全球干预进展[J]. 中国儿童保健杂志, 2020, 28(6): 649-652+709.
[15] Baume, L.J., Franquin, J.C. and Körner, W.W. (1972) The Prenatal Effects of Maternal Vitamin A Deficiency on the Cranial and Dental Development of the Progeny. American Journal of Orthodontics, 62, 447-460. [Google Scholar] [CrossRef] [PubMed]
[16] Kheirvari, S., Uezu, K., Sakai, T., Nakamori, M., Alizadeh, M., Sarukura, N. and Yamamoto, S. (2006) Increased Nerve Growth Factor by Zinc Supplementation with Concurrent Vitamin A Deficiency Does Not Improve Memory Performance in Mice. Journal of nutritional Science and Vitaminology, 52, 421-427. [Google Scholar] [CrossRef] [PubMed]
[17] Cocco, S., Diaz, G., Stancampiano, R., Diana, A., Carta, M., Curreli, R., Sarais, L. and Fadda, F. (2002) Vitamin A Deficiency Produces Spatial Learning and Memory Impairment in Rats. Neuroscience, 115, 475-482. [Google Scholar] [CrossRef] 
[18] Tanumihardjo, S.A. (2013) Vitamin A and Bone Health: The Balancing Act. Journal of Clinical Densitometry, 16, 414-419. [Google Scholar] [CrossRef] [PubMed]
[19] Mehta N.M., Corkins, M.R., Lyman, B., Malone, A., Goday, P.S., Carney, L.N., Monczka, J.L., Plogsted, S.W. and Frederick, S.W. (2013) Defining Pediatric Malnutrition: A Paradigm Shift toward Etiology-Related Definitions. Journal of Parenteral and Enteral Nutrition, 37, 460-481. [Google Scholar] [CrossRef] [PubMed]
[20] Cao, J.-Y., Wei, X.-P., Tang, X.-Q., Jiang, H.-P., Fan, Z., Yu, Q., Chen, J., Liu, Y.-X. and Li, T.-Y. (2013) Effects of Egg and Vitamin A Supplementation on Hemoglobin, Retinol Status and Physical Growth Levels of Primary and Middle School Students in Chongqing, China. Asia Pacific Journal of Clinical Nutrition, 22, 214-221.
[21] Zadik, Z., Sinai, T., Zung, A. and Reifen, R. (2004) Vitamin A and Iron Supplementation Is as Efficient as Hormonal Therapy in Constitutionally Delayed Children. Clinical Endocrinology, 60, 682-687. [Google Scholar] [CrossRef] [PubMed]
[22] Reifen, R., Nur, T., Ghebermeskel, K., Zaiger, G., Urizky, R. and Pines, M. (2002) Vitamin A Deficiency Exacerbates Inflammation in a Rat Model of Colitis through Activation of Nuclear Factor-Kappab and Collagen Formation. The Journal of Nutrition, 132, 2743-2747. [Google Scholar] [CrossRef] [PubMed]
[23] Mallett, R., Simmonds, S., Kuppurajan, A., Narayanan, A., Balasubramanian, K. and Ramakrishnan, S. (2015) Neonatal Aortic Dilatation Secondary to Vitamin A Deficiency. Pediatrics, 135, e1321-5.
[24] Swami, H.M, Thakur, J.S. and Bhatia, S.P.S. (2007) Impact of Mass Supplementation of Vitamin A. The Indian Journal of Pediatrics, 74, 443-447. [Google Scholar] [CrossRef] [PubMed]
[25] Riccioni, G., Bucciarelli, T., Mancini, B., Di Ilio, C., Della Vecchia, R. and D’orazio, N. (2007) Plasma Lycopene and Antioxidant Vitamins in Asthma: The Plava Study. Journal of Asthma, 44, 429-432. [Google Scholar] [CrossRef] [PubMed]
[26] 李丽梅, 李伟英. 5岁以下儿童维生素A亚临床缺乏与贫血和呼吸道感染的关系及预防措施[J]. 临床和实验医学杂志, 2014, 13(22): 1889-1891.
[27] Amaral, C.T., Pontes, N.N., Maciel, B.L.L., Bezerra, H.S.M., Triesta, A.N.A.B., Jeronimo, S.M.B., Mcgowan, S.E. and Dantas, V.M. (2013) Vitamin A Deficiency Alters Airway Resistance in Children with Acute Upper Respiratory Infection. Pediatric Pulmonology, 48, 481-489. [Google Scholar] [CrossRef] [PubMed]
[28] Pino-Lagos, K., Guo, Y.X. and Noelle, R.J. (2010) Retinoic Acid: A Key Player in Immunity. BioFactors, 36, 430-436. [Google Scholar] [CrossRef] [PubMed]
[29] Dong, P., Tao, Y.H., Yang, Y. and Wang, W.P. (2010) Expression of Retinoic Acid Receptors in Intestinal Mucosa and the Effect of Vitamin A on Mucosal Immunity. Nutrition, 26, 740-745. [Google Scholar] [CrossRef] [PubMed]
[30] Nur, T., Peijnenburg, A.A.C.M., Noteborn, H.P.J.M., Baykus, H. and Reifen, R. (2002) Dna Microarray Technology Reveals Similar Gene Expression Patterns in Rats with Vitamin A Deficiency and Chemically Induced Colitis. The Journal of Nutrition, 132, 2131-2136. [Google Scholar] [CrossRef] [PubMed]
[31] Amit-Romach, E., Uni, Z., Cheled, S., Berkovich, Z. and Reifen, R. (2009) Bacterial Population and Innate Immunity-Related Genes in Rat Gastrointestinal Tract Are Altered by Vitamin A-Deficient Diet. The Journal of Nutritional Biochemistry, 20, 70-77. [Google Scholar] [CrossRef] [PubMed]
[32] 陶懂谊, 马文领. 维生素A的生物学作用及其缺乏的防治[J]. 中国医药导报, 2013, 10(1): 25-26+29.
[33] Citelli, M., Bittencourt, L.L., Silva, S.V., Pierucci, A.P.T. and Pedrosa, C. (2012) Vitamin A Modulates the Expression of Genes Involved in Iron Bioavailability. Biological Trace Element Research, 149, 64-70. [Google Scholar] [CrossRef] [PubMed]
[34] 宰宇. 中国人群维生素与营养性贫血相关性的Meta分析[D]: [硕士学位论文]. 衡阳: 大学, 2015.
[35] Saraiva, B.C.A., Soares, M.C.C., Dos Santos, L.C., Pereira, S.C.L. and Horta, P.M. (2014) Iron Deficiency and Anemia Are Associated with Low Retinol Levels in Children Aged 1 to 5 Years. Jornal De Pediatria, 90, 593-599. [Google Scholar] [CrossRef] 
[36] 姜珊. 维生素A缺乏对大鼠铁调节蛋白的影响研究[D]: [硕士学位论文]. 黑龙江: 哈尔滨医科大学, 2011.
[37] Lima, A.A., Soares, A.M., Lima, N.L., Mota, R., Maciel, B.L., Kvalsund, M.P., Barrett, L.J., Fitzgerald, R.P., Blaner, W.S. and Guerrant, R.L. (2010) Effects of Vitamin A Supplementation on Intestinal Barrier Function, Growth, Total Parasitic, and Specific Giardia spp Infections in Brazilian Children: A Prospective Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Pediatric Gastroenterology and Nutrition, 50, 309-315. [Google Scholar] [CrossRef] 
[38] Stitaya, S. (2015) The Pleiotropic Role of Vitamin A in Regulating Mucosal Immunity. Asian Pacific Journal of Allergy and Immunology, 33, 71-89.
[39] Hall, J.A., Grainger, J.R., Spencer, S.P. and Belkaid, Y. (2011) The Role of Retinoic Acid in Tolerance and Immunity. Immunity, 35, 13-22. [Google Scholar] [CrossRef] [PubMed]
[40] Perusek, L., Maeda, A. and Maeda, T. (2015) Supplementation with Vitamin A Derivatives to Rescue Vision in Animal Models of Degenerative Retinal Diseases. In: Jastrzebska, B., Ed., Methods in Molecular Biology, Humana Press, New York, 345-362. [Google Scholar] [CrossRef] [PubMed]

为你推荐