血浆D-二聚体评估晚期胃癌疗效的临床价值

Clinical Value of Plasma D-Dimer in Evaluating the Curative Effect of Advanced Gastric Cancer

摘要: 目的：探讨血浆D-二聚体在评估晚期胃癌近期疗效中的临床价值。方法：选取2014年1月至2016年12月在我院住院治疗的IV期胃癌患者94例，研究患者血浆D-二聚体水平与一般临床特征的相关性，评估治疗前后血浆D-二聚体水平变化与疗效的相关性。结果：晚期胃癌的化疗有效组患者血浆D-二聚体水平降低，而无效组血浆D-二聚体水平升高，提示其在晚期胃癌评价疗效方面的价值，可以用于评估晚期胃癌的近期疗效。研究还发现，晚期胃癌D-二聚体值及治疗疗效也许与肿瘤的转移部位有相关性，但本研究样本数量有限，尚需进一步验证结论。结论：晚期胃癌血浆D-二聚体水平明显升高，且D-二聚体值及治疗疗效与肿瘤的转移部位有相关性，治疗前后血浆D-二聚体水平的变化可作为晚期胃癌近期疗效评估的依据。但本研究样本量偏少，所得出的结果可能存在偏倚，尚需进一步研究证实。

Abstract: Objective: To explore the clinical value of plasma D-dimer in assessing the short-term efficacy of advanced gastric cancer. Methods: The correlation between plasma D-dimer level and general clinical characteristics was studied in 94 IV gastric cancer patients hospitalized in our hospital from January 2014 to December 2016 and to evaluate the correlation between plasma D-dimer level and curative effect before and after treatment. Results: The plasma D-dimer level in the chemotherapy effective group of advanced gastric cancer decreased, while the plasma D-dimer level in the ineffective group increased, suggesting its value in evaluating the efficacy of advanced gastric cancer, which can be used to evaluate the short-term efficacy of advanced gastric cancer. D-dimer value and therapeutic efficacy of advanced gastric cancer may be related to the metastatic site of the tumor, but the number of samples in this study is limited, which needs further verification. Conclusion: The plasma D-dimer level of advanced gastric cancer is obviously increased, and the D-dimer value and therapeutic effect are related to the metastasis site of the tumor. The change of plasma D-dimer level before and after treatment can be used as the basis for the evaluation of the short-term curative effect of advanced gastric cancer. However, the sample size of this study is small, and the results may be biased, which needs further study and confirmation.