ESM1:一个癌症治疗的新靶点
ESM1: A New Target for Cancer Therapy
DOI: 10.12677/PI.2021.103016, PDF,   
作者: 梁 雪, 刘 煜*:中国药科大学生命科学与技术学院,江苏 南京
关键词: ESM1血管生成癌症ESM1 Angiogenesis Cancers
摘要: ESM1,又称Endocan,是一种50 kDa的富含半胱氨酸的分泌型蛋白聚糖,包含一个20 kDa的蛋白质核心和一条与其共价结合的硫酸皮肤素糖链。正常组织中,ESM1在血管内皮细胞、肾远端小管上皮细胞、支气管和肺粘膜下腺表达。近年来研究发现,ESM1在肺癌、肾癌、肝癌、乳腺癌、脑胶质母细胞瘤等多种恶性肿瘤中高表达,且与肿瘤血管生成、转移和预后不良相关。有研究者认为,ESM1可能成为癌症治疗的新靶点。本文旨在对ESM1的结构、功能,及其在多种炎症疾病和癌症中的研究进展进行综述。
Abstract: ESM1, also called Endocan, is a 50 kDa cysteine-rich secreted proteoglycan, containing a 20 kDa core protein and a single dermatan sulfate chain. In normal tissues, ESM1 is secreted by vascular endothelial cells, epithelial cells lining renal distal tubules, bronchi, and lung submucosal glands. Recent research has shown that ESM1 expression is overexpressed in lung cancer, kidney cancer, liver cancer, breast cancer, brain glioblastoma and other tumors. Tumor angiogenesis, metastasis and prognosis were shown to be associated with Endocan expression. Investigators believe that ESM1 may be a new target for cancer therapy. This article aims to review the structure and function of ESM1, as well as the research progress in a variety of inflammatory diseases and cancers.
文章引用:梁雪, 刘煜. ESM1:一个癌症治疗的新靶点[J]. 药物资讯, 2021, 10(3): 121-128. https://doi.org/10.12677/PI.2021.103016

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