间充质干细胞临床研究与应用进展
Advances in Clinical Research and Application of Mesenchymal Stem Cells
DOI: 10.12677/ACM.2022.122208, PDF,    国家自然科学基金支持
作者: 彭定伟：天津大学新城医院神经外科，天津；徐 健*, 董化江*：武警后勤学院，天津
关键词: 细胞替代治疗；间充质干细胞；免疫调节；血管新生；Cell Replacement； Mesenchymal Stem Cells； Immunological Regulation； Angiogenesis
摘要: 间充质干细胞(mesenchymal stem cells, MSCs)是一类具有分化、增殖能力，能再生多种组织和器官的“种子细胞”，当前MSCs在免疫治疗、细胞治疗、损伤组织修复等诸多领域显示出治疗优势和应用前景，是多种疑难杂症治疗的明星细胞。MSCs获取简单，扩增能力强，免疫调节能力强大，无需进行严格的配型，致瘤性低，使用安全，治疗效果可靠，为广大科研和医务工作者所青睐。本文就MSCs在支持造血、促进血管再生、缺血性疾病的防治、糖尿病的治疗、肝硬化的治疗、神经系统疾病的治疗、风湿免疫性疾病的治疗以及再生方面的应用进行综述。
Abstract: Mesenchymal stem cells (MSCs) are a kind of “seed cell” which can differentiate and proliferate and regenerate to such tissues and organs. At present, MSCs have shown therapeutic advantages and application prospects in many fields such as immunotherapy, cell therapy, repair of damaged tissues, etc., which are the star cells for the treatment of various incurable diseases. MSCs have the advantages of simple acquisition, strong amplification ability, strong immuno-regulation ability, no need for strict matching, low tumorigenicity, safe use and reliable treatment effects, and are favored by the majority of scientific research and medical workers. This article reviews the application of MSCs in supporting hematopoiesis, promoting blood vessel regeneration, preventing and treating ischemic diseases, diabetes, liver cirrhosis, nervous system diseases, rheumatic immune diseases and regeneration.
文章引用：彭定伟, 徐健, 董化江. 间充质干细胞临床研究与应用进展[J]. 临床医学进展, 2022, 12(2): 1433-1438. https://doi.org/10.12677/ACM.2022.122208

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