血管源性脑白质高信号与全身免疫炎症指数的相关性研究进展
Research Progress on the Correlation between White Matter Hyperintensity of Presumed Vascular Origin and Systemic Immune-Inflammation Index
摘要: 血管源性脑白质高信号(white matter hyperintensities, WMH)常见于老年人群中。目前其发病机制尚不明确，随着研究的不断深入，发现炎症反应在WMH的发生、发展中起着十分重要的作用。因此，基于各种血细胞计数比率的炎症标志物可成为预测WMH发生、发展的有效指标，而包含中性粒细胞、淋巴细胞及血小板的全身免疫炎症指数(systemic immune-inflammation index, SII)能客观、稳定、系统地反应机体全身炎症及免疫状态。此外，我国的老龄化程度越来越高，WMH的患病率也将逐渐增加，而SII的检测对机体的侵袭性小、获取及保存简便、准确度及成本效益高，易在临床推广运用。因此，本文就WMH与SII相关性的临床研究进展进行综述。
Abstract: White matter hyperintensity of presumed vascular origin (WMH) are common in older adults. At present, its pathogenesis is still unclear. With the developing of research, it is discovered that in-flammatory response plays a vital role in the occurrence and development of WMH. Therefore, in-flammatory markers based on various blood cell count ratios can become effective indicators for predicting the occurrence and development of WMH, and the systemic immune-inflammation index (SII) including neutrophils, lymphocytes and platelets can objectively, stably, systemically respond to the body’s systemic inflammation and immune status. In addition, our country’s aging degree is getting higher and higher, and the prevalence of WMH will gradually increase. However, the detec-tion of SII is less invasive to the body and easy to obtain and store. Furthermore, it has high accura-cy and cost-effectiveness, and is easy to be applied in clinical practice. Therefore, this article reviews the clinical research progress on the relationship between WMH and SII.
文章引用：钟诚兴, 拜承萍. 血管源性脑白质高信号与全身免疫炎症指数的相关性研究进展[J]. 临床医学进展, 2022, 12(10): 9589-9595. https://doi.org/10.12677/ACM.2022.12101387

参考文献

[1] Wardlaw, J.M., Smith, E.E., Biessels, G.J., Cordonnier, C., et al. (2013) Neuroimaging Standards for Research into Small Vessel Disease and Its Contribution. The Lancet Neurology, 12, 822-838. [Google Scholar] [CrossRef] 
[2] TerTelgte, A., van Leijsen, E.M.C., Wiegertjes, K., et al. (2018) Cerebral Small Vessel Disease: From a Focal to a Global Perspective. Nature Reviews Neurology, 14, 387-398. [Google Scholar] [CrossRef] [PubMed]
[3] Patel, B. and Markus, H.S. (2011) Magnetic Resonance Imaging in Cerebral Small Vessel Disease and Its Use as a Surrogate Disease Marker. International Journal of Stroke, 6, 47-59. [Google Scholar] [CrossRef] [PubMed]
[4] Gong, P., Liu, Y., Gong, Y., Chen, G., et al. (2021) The Association of Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Lymphocyte to Monocyte Ratio with Post-Thrombolysis Early Neurological Outcomes in Patients with Acute Ischemic Stroke. Journal of Neuroinflammation, 18, Article No. 51. [Google Scholar] [CrossRef] [PubMed]
[5] Nam, K.W., Kwon, H.M., Jeong, H.Y., et al. (2022) Systemic Immune-Inflammation Index Is Associated with White Matter Hyperintensityvolume. Scientific Reports, 12, Article No. 7379. [Google Scholar] [CrossRef] [PubMed]
[6] Hachinski, V.C., Potter, P. and Merskey, H. (1987) Leu-ko-Araiosis. Archives of Neurology, 44, 21-23. [Google Scholar] [CrossRef] [PubMed]
[7] Kim, K.W., MacFall, J.R. and Payne, M.E. (2008) Classification of White Matter Lesions on Magnetic Resonance Imaging in Elderly Persons. Biological Psychiatry, 64, 273-280. [Google Scholar] [CrossRef] [PubMed]
[8] Sachdev, P., Wen, W., Chen, X., et al. (2007) Pro-gression of White Matter Hyperintensities in Elderly Individuals over 3 Years. Neurology, 68, 214-222. [Google Scholar] [CrossRef] [PubMed]
[9] Chen, X., Wang, J., Shan, Y., et al. (2019) Cerebral Small Vessel Disease: Neuroimaging Markers and Clinical Implication. Journal of Neurology, 266, 2347-2362. [Google Scholar] [CrossRef] [PubMed]
[10] Hiremath, N., Kate, M., Mohimen, A., et al. (2020) Risk Factors of White Matter Hyperintensities in South Asian Patients with Transient Ischemic Attack and Minor Stroke. Neuroradi-ology, 62, 1279-1284. [Google Scholar] [CrossRef] [PubMed]
[11] deLeeuw, F.E., de Groot, J.C., Achten, E., et al. (2001) Preva-lence of Cerebral White Matter Lesions in Elderly People: A Population Based Magnetic Resonance Imaging Study: The Rotterdam Scan Study. Journal of Neurology, Neurosurgery and Psychiatry, 70, 9-14. [Google Scholar] [CrossRef] [PubMed]
[12] Wen, W., Sachdev, P.S., Li, J.J., et al. (2009) White Matter Hyperintensi-ties in the Forties: Their Prevalence and Topography in an Epidemiological Sample Aged 44 - 48. Human Brain Mapping, 30, 1155-1167. [Google Scholar] [CrossRef] [PubMed]
[13] Launer, L.J., Berger, K., Breteler, M.M., et al. (2006) Regional Variability in the Prevalence of Cerebral White Matter Lesions: An MRI Study in 9 European Countries (CASCADE). Neuroepide-miology, 26, 23-29. [Google Scholar] [CrossRef] [PubMed]
[14] Lin, Q., Huang, W.Q., Ma, Q.L., et al. (2017) Incidence and Risk Factors of Leukoaraiosis from 4683 Hospitalized Patients: A Cross-Sectional Study. Medicine, 96, e7682. [Google Scholar] [CrossRef] 
[15] Jorgensen, D.R., Shaaban, C.E., Wiley, C.A., et al. (2018) A Population Neuroscience Approach to the Study of Cerebral Small Vessel Disease in Midlife and Late Life: An Invited Review. The American Journal of Physiology-Heart and Circulatory Physiology, 314, H1117-H1136. [Google Scholar] [CrossRef] [PubMed]
[16] vanDijk, E.J., Prins, N.D., Vrooman, H.A., et al. (2008) Pro-gression of Cerebral Small Vessel Disease in Relation to Risk Factors and Cognitive Consequences: Rotterdam Scan Study. Stroke, 39, 2712-2719. [Google Scholar] [CrossRef] 
[17] Cho, A.H., Kim, H.R., Kim, W., et al. (2015) White Mat-ter Hyperintensity in Ischemic Stroke Patients: It May Regress Overtime. Journal of Stroke, 17, 60-66. [Google Scholar] [CrossRef] [PubMed]
[18] Etherton, M.R., Wu, O. and Rost, N.S. (2016) Recent Advances in Leukoaraiosis: White Matter Structural Integrity and Functional Outcomes after Acute Ischemic Stroke. Current Cardi-ology Reports, 18, Article No. 123. [Google Scholar] [CrossRef] [PubMed]
[19] Chen, H., Huang, L., Yang, D., et al. (2019) Nodal Global Effi-ciency in Front-Parietal Lobe Mediated Periventricular White Matter Hyperintensity (PWMH)-Related Cognitive Impair-ment. Frontiers in Aging Neuroscience, 11, Article No. 347. [Google Scholar] [CrossRef] [PubMed]
[20] Debette, S., Schilling, S., Duperron, M.G., et al. (2019) Clinical Significance of Magnetic Resonance Imaging Markers of Vascu-lar BrainInjury: A Systematic Review and Meta-Analysis. JAMA Neurology, 76, 81-94. [Google Scholar] [CrossRef] [PubMed]
[21] Kuller, L.H., Longstreth, W.T., Arnold, A.M., et al. (2004) White Matter Hyperintensity on Cranial Magnetic Resonance Imaging: A Predictor of Stroke. Stroke, 35, 1821-1825. [Google Scholar] [CrossRef] 
[22] Park, J.H., Heo, S.H., Lee, M.H., et al. (2019) White Matter Hyperintensities and Recurrent Stroke Risk in Patients with Stroke with Small-Vessel Disease. European Journal of Neurology, 26, 911-918. [Google Scholar] [CrossRef] [PubMed]
[23] Helenius, J., Goddeau, R.P., et al. (2016) Impact of Leukoaraiosis Burden on Hemispheric Lateralization of the National Institutes of Health Stroke Scale Deficit in Acute Ischemic Stroke. Stroke, 47, 24-30. [Google Scholar] [CrossRef] 
[24] Swardfager, W., Yu, D., Ramirez, J., et al. (2017) Pe-ripheral Inflammatory Markers Indicate Microstructural Damage within Periventricular White Matter Hyperintensities in Alzheimer’s Disease: A Preliminary Report. Alzheimer’s Dement, 7, 56-60. [Google Scholar] [CrossRef] [PubMed]
[25] Lin, J., Wang, D., Lan, L., Fan, Y., et al. (2017) Multiple Factors Involved in the Pathogenesis of White Matter Lesions. BioMed Research International, 2017, Article ID: 9372050. [Google Scholar] [CrossRef] [PubMed]
[26] Moody, D.M., Brown, W.R., Challa, V.R., et al. (1995) Periventricular Venous Collagenosis: Association with Leukoaraiosis. Radiology, 194, 469-476. [Google Scholar] [CrossRef] [PubMed]
[27] Lan, L.F., Zheng, L., Yang, X., et al. (2015) Peroxisome Proliferator-Activated Receptor-γ Agonist Pioglitazone Ameliorates White Matter Lesion and Cognitive Impairment in Hypertensive Rats. CNS Neuroscience & Therapeutics, 21, 410-416. [Google Scholar] [CrossRef] [PubMed]
[28] Atwood, L.D., Wolf, P.A., Heard-Costa, N.L., et al. (2004) Genetic Varia-tion in White Matter Hyperintensity Volume in the Framingham Study. Stroke, 35, 1609-1613. [Google Scholar] [CrossRef] 
[29] Huisa, B.N., Caprihan, A., Thompson, J., et al. (2015) Long-Term Blood-Brain Barrier Permeability Changes in Binswanger Disease. Stroke, 46, 2413-2418. [Google Scholar] [CrossRef] 
[30] Brown, W.R., Moody, D.M., Challa, V.R., et al. (2002) Venous Collagenosis and Arteriolar Tortuosity in Leukoaraiosis. Journal of the Neurological Sciences, 204, 159-163. [Google Scholar] [CrossRef] 
[31] Hu, B., Yang, X.R., Xu, Y., et al. (2014) Systemic Im-mune-Inflammation Index Predicts Prognosis of Patients after Curative Resection for Hepatocellular Carcinoma. Clinical Cancer Research, 20, 6212-6222. [Google Scholar] [CrossRef] 
[32] Topcuoglu, M.A., Pektezel, M.Y., Yilmaz, E., et al. (2021) Systemic Inflammation Indices in Patients with Acute Ischemic Stroke Treated with Intravenous Tissue Plasminogen Ac-tivator: Clinical Yield and Utility. Angiology, 72, 279-284. [Google Scholar] [CrossRef] [PubMed]
[33] Eraslan, E., Adas, Y.G., Yildiz, F., et al. (2021) Systemic Immune-Inflammation Index (SII) Predicts Pathological Complete Re-sponseto Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer. Journal of College of Physicians and Surgeons Pakistan, 30, 399-404. [Google Scholar] [CrossRef] [PubMed]
[34] Keit, E., Coutu, B., Zhen, W., et al. (2021) Systemic Inflammation Is Associated with Inferior Disease Control and Survival in Stage III Non-Small Cell Lung Cancer. Annals of Translational Medicine, 9, Article No. 227. [Google Scholar] [CrossRef] [PubMed]
[35] Fu, S., Yan, J., Tan, Y., et al. (2021) Prognostic Value of Systemic Immune-Inflammatory Index in Survival Outcome in Gastric Cancer: A Meta-Analysis. Journal of Gastrointestinal On-cology, 12, 344-354. [Google Scholar] [CrossRef] [PubMed]
[36] Bittoni, A., Pecci, F., Mentrasti, G., et al. (2021) Systemic Im-mune-Inflammation Index: A Prognostic Tiebreaker among All in Advanced Pancreatic Cancer. Annals of Translational Medicine, 9, Article No. 251. [Google Scholar] [CrossRef] [PubMed]
[37] Jin, Z., Wu, Q., Chen, S., Gao, J., et al. (2021) The Associations of Two Novel Inflammation Indexes, SII and SIRI with the Risks for Cardiovascular Diseases and All-Cause Mortality: A Ten-Year Follow-Up Study in 85,154 Individuals. Journal of Inflammation Research, 14, 131-140. [Google Scholar] [CrossRef] [PubMed]
[38] Adiguzel, A., Arsava, E.M. and Topcuoglu, M.A. (2022) Temporal Course of Peripheral Inflammation Markers and Indexes Following Acute Ischemic Stroke: Prediction of Mortality, Functional Outcome, and Stroke-Associated Pneumonia. Neurological Research, 44, 224-231. [Google Scholar] [CrossRef] [PubMed]
[39] 侯赋成, 殷梅. 脑白质病变的病理学及发病机制的研究进展[J]. 临床神经病学杂志, 2018, 31(4): 310-313.
[40] 韩博, 吴舜, 何先东, 等. 基于免疫细胞计数的系统性炎症反应指数在预测肾透明细胞癌患者预后中的作用研究[J]. 免疫学杂志, 2020, 36(2): 160-164+184.
[41] Low, A., Mak, E., Rowe, J.B., et al. (2019) Inflammation and Cerebral Small Vessel Disease: A Systematic Review. Ageing Research Reviews, 53, Article ID: 100916. [Google Scholar] [CrossRef] [PubMed]
[42] vanDijk, E.J., Prins, N.D., Vermeer, S.E., et al. (2005) C-Reactive Protein and Cerebral Small-Vessel Disease: The Rotterdam Scan Study. Circulation, 112, 900-905. [Google Scholar] [CrossRef] 
[43] Raggi, P., Genest, J., Giles, J.T., et al. (2018) Role of Inflammation in the Pathogenesis of Atherosclerosis and Therapeutic Interventions. Ath-erosclerosis, 276, 98-108. [Google Scholar] [CrossRef] [PubMed]

为你推荐