SGLT2抑制剂在动物模型中治疗心肌缺血再灌注损伤的机制
Mechanisms of SGLT2 Inhibitors in the Treatment of Myocardial Ischemia-Reperfusion Injury in Animal Models
摘要: SGLT2抑制剂在多个大型临床试验研究中显示出良好的心血管保护作用,包括减轻2型糖尿病及非2型糖尿病患者的心衰发生率、全因死亡率、改善心室功能等。但SGLT2抑制剂对急性心肌梗死患者的治疗疗效及预后尚不十分明确,其机制仍在探索阶段。本文主要针对有关心肌梗死的相关动物实验中,SGLT2抑制剂对心脏保护作用潜在机制作一综述。
Abstract: SGLT2 inhibitors have shown promising cardiovascular protective effects in many large clinical tri-als, including reduced incidence of heart failure, all-cause mortality and improved ventricular func-tion in both type 2 diabetic patients and non-type 2 diabetic patients. However, the therapeutic ef-fects and prognosis of SGLT2 inhibitors in patients with acute myocardial infarction are not well de-fined, and the mechanisms are still being explored. This article reviews the potential mechanisms of cardioprotection by SGLT2 inhibitors in myocardial infarction-related animal studies.
文章引用:黎人榕, 佘强. SGLT2抑制剂在动物模型中治疗心肌缺血再灌注损伤的机制[J]. 临床医学进展, 2023, 13(2): 2232-2240. https://doi.org/10.12677/ACM.2023.132313

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