可溶性止血纱布对脑外科手术止血效果的影响

Homeostatic Effect of Soluble Gauze in the Brain Surgery

摘要: 可溶性止血纱布由于组织相容性良好，可体内吸收，临床上广泛应用于神经、肝脏等创面出血及渗血不易停止部位的手术。本研究主要考察国产可溶性止血纱布(荣雪芷)和进口可溶性止血纱布在脑外科手术中止血效果。结果表明：1) 在脑外科手术中无论国产可溶性止血纱布(荣雪芷)还是进口可溶性止血纱布均能显著缩短出血时间，减少出血量，缩短术后引流天数，与明胶海绵组、普通止血纱布组和空白对照比均有统计学意义(p值均< 0.05或0.01)；2) 但是国产可溶性止血纱布(荣雪芷)组和进口可溶性止血纱布组无显著区别(p > 0.05)；3) 术后随访3月，均未发现国产可溶性止血纱布(荣雪芷)、进口可溶性止血纱布、明胶海绵或普通止血纱布引发不良反应。结果提示，脑外科手术使用国产可溶性止血纱布(荣雪芷)止血效果良好，其效果与应用广泛进口名牌可溶性止血纱布相当。

Abstract: Soluble gauze has been widely using in the clinical surgery that is difficult to stanch bleeding, for example brain surgery and liver surgery, because of its good tissue compatibility and being absorbed by the body. The present study was to investigate the homeostatic effect of the domestic soluble gauze (Rong Xue Zhi) and import soluble gauze in the brain surgery. The results showed that: 1) Not only the domestic soluble gauze (Rong Xue Zhi) but also the im-port soluble gauze could significantly decrease the bleeding time, bleeding volume and drainage time in the brain sur-gery, which had a statistical different with the gelatin sponge and normal gauze effect (all p < 0.05 or 0.01); 2) It was not statistical different for the bleeding time, bleeding volume and drainage time between the domestic soluble gauze (Rong Xue Zhi) and the import soluble gauze (p > 0.05); and 3) There were no side effects induced by the domestic soluble gauze (Rong Xue Zhi), import soluble gauze, gelatin sponge or normal gauze following 3 months after the brain surgery. The data suggested that the domestic soluble gauze (Rong Xue Zhi) played a role in homeostasis in the brain surgery, which was same as the import soluble gauze in the homeostatic effect.