血管内皮损伤标志物血栓调节蛋白与代谢综合征相关性的研究进展
Research Progress in the Association of Thrombomodulin, a Marker of Vascular Endothelial Injury, and Metabolic Syndrome
摘要: 代谢综合征是导致心脑血管疾病发生的危险因素之一，严重威胁人类生命健康。研究发现，血管内皮功能在疾病的发展进程中发挥着至关重要的作用，因此，积极监测把控血管内皮功能有望成为代谢综合征疾病防治的新靶点，本文综述了血管内皮损伤标志物，即血栓调节蛋白与代谢综合征的关系，及中医药治疗对血管内皮功能的改善，旨在为代谢综合征的防治提供参考。
Abstract: Metabolic syndrome is one of the risk factors for the development of cardiovascular and cerebro-vascular diseases, which is a serious threat to human life and health. It has been found that vascular endothelial function plays a crucial role in the development of the disease, therefore, active moni-toring and control of vascular endothelial function is expected to become a new target for the pre-vention and treatment of metabolic syndrome. This article reviews the vascular endothelial damage markers, i.e., the relationship between thrombomodulin and metabolic syndrome, and the im-provement of vascular endothelial function by traditional Chinese medicine therapy, which is aimed at providing references for the prevention and treatment of metabolic syndrome.
文章引用：杨舜雯. 血管内皮损伤标志物血栓调节蛋白与代谢综合征相关性的研究进展[J]. 临床医学进展, 2023, 13(9): 14033-14037. https://doi.org/10.12677/ACM.2023.1391962

参考文献

[1] Daiber, A., Steven, S., Weber, A., et al. (2017) Targeting Vascular (Endothelial) Dysfunction: Targeting Vascular (En-dothelial) Dysfunction. British Journal of Pharmacology, 174, 1591-1619. [Google Scholar] [CrossRef] [PubMed]
[2] Ghosh, A., Gao, L., Thakur, A., et al. (2017) Role of Free Fatty Acids in Endothelial Dysfunction. Journal of Biomedical Science, 24, Article No. 50. [Google Scholar] [CrossRef] [PubMed]
[3] 杨晨, 全首祯, 马越云, 等. 血管内皮损伤标志物的研究进展[J]. 医学综述, 2022, 28(12): 2357-2362.
[4] 莫丽萍. 血管内皮功能及IMT超声检测对冠心病的诊断效果[J]. 中国实用医药, 2021, 16(24): 23-25. [Google Scholar] [CrossRef] 
[5] 肖艳, 陈明. 血管内皮功能检测[J]. 中华高血压杂志, 2016, 24(9): 883-887. [Google Scholar] [CrossRef] 
[6] 李丹, 李玉洁, 杨庆, 等. 血管内皮功能障碍与动脉粥样硬化研究进展[J]. 中国实验方剂学杂志, 2012, 18(8): 272-276. [Google Scholar] [CrossRef] 
[7] Kaur, R., Kaur, M. and Singh, J. (2018) Endothelial Dys-function and Platelet Hyperactivity in Type 2 Diabetes Mellitus: Molecular Insights and Therapeutic Strategies. Cardio-vascular Diabetology, 17, Article No. 121. [Google Scholar] [CrossRef] [PubMed]
[8] Gimbrone, M.A. and García-Cardeña, G. (2016) Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Circulation Research, 118, 620-636.
[9] Ito, T., Thachil, J., Asakura, H., et al. (2019) Thrombomodulin in Disseminated Intravascular Coagulation and Other Critical Conditions—A Multi-Faceted Anticoagulant Protein with Therapeutic Potential. Critical Care, 23, Article No. 280.
[10] 钟延法, 雷朝英, 李元民, 等. 微小RNA-221和巨噬细胞迁移抑制因子及血栓调节蛋白与心房颤动并缺血性脑卒中的相关性[J]. 中华老年心脑血管病杂志, 2022, 24(3): 273-276.
[11] Loghmani, H. and Conway, E.M. (2018) Exploring Tradi-tional and Nontraditional Roles for Thrombomodulin. Blood, 132, 148-158.
[12] Watanabe-Kusunoki, K., Nakazawa, D., Ishizu, A., et al. (2020) Thrombomodulin as a Physiological Modulator of Intravascular Injury. Frontiers in Immunology, 11, Article ID: 575890.
[13] 高振忠, 王艳, 李争争, 等. 血浆可溶性血栓调节蛋白水平与缺血性卒中患者rt-PA静脉溶栓后早期神经功能恶化的关系[J]. 中国动脉硬化杂志, 2022, 30(7): 589-593. [Google Scholar] [CrossRef] 
[14] 马桂鑫, 赵文文, 陈修平. 血管内皮细胞损伤模型及中药保护作用研究进展[J]. 中草药, 2014, 45(2): 276-283.
[15] 吴旭, 季爽, 郭燕, 等. NAC/RvD1抑制H2O2诱导的COPD患者气道上皮细胞炎症性黏液高分泌的作用及机制研究[J]. 安徽医科大学学报, 2021, 56(12): 1853-1859. [Google Scholar] [CrossRef] 
[16] 伏江龙, 杨雪, 万宛若, 等. 中药单体通过NF-κB信号通路防治动脉粥样硬化研究进展[J]. 中国实验方剂学杂志, 2022, 28(17): 195-208. [Google Scholar] [CrossRef] 
[17] 鲁艳军. 富含甘油三酯脂蛋白致泡沫细胞的蛋白组学研究[D]: [博士学位论文]. 武汉: 华中科技大学, 2010.
[18] 周韵. 氧化应激损伤中NFKB1多态性对NF-κB信号通路及细胞凋亡的分子机制研究[D]: [硕士学位论文]. 乌鲁木齐: 新疆医科大学, 2016.
[19] 刘旺华, 李花, 肖献忠. 高迁移率族蛋白B-1与炎症关系的研究进展[J]. 中国病理生理杂志, 2008(8): 1656-1660.
[20] 杨琼. 高迁移率族蛋白1-Toll样受体4对大鼠心肌缺血再灌注损伤后炎症反应的影响[J]. 中国医学前沿杂志(电子版), 2022, 14(3): 8-13.
[21] Kawai, T., Autieri, M.V. and Scalia, R. (2021) Adipose Tissue Inflammation and Metabolic Dysfunction in Obesity. American Journal of Physiology. Cell Physiology, 320, C375-C391.
[22] Matulewicz, N. and Kar-czewska-Kupczewska, M. (2016) Insulin Resistance and Chronic Inflammation. Postepy Higieny I Medycyny Doswi-adczalnej (Online), 70, 1245-1258.
[23] Agita, A. and Alsagaff, M.T. (2017) Inflammation, Immunity, and Hyperten-sion. Acta Medica Indonesiana, 49, 158-165.
[24] 吴培福, 余明众, 黄澄渊, 等. 高迁移率族蛋白1基因多态性与代谢综合征的相关性[J]. 中华高血压杂志, 2018, 26(3): 258-264. [Google Scholar] [CrossRef] 
[25] 周景莉, 曹向红, 张虹. 代谢综合征对原发性高血压患者颈动脉硬化的影响研究[J]. 中国药物与临床, 2021, 21(2): 213-216.
[26] Kang, R., Chen, R., Zhang, Q., et al. (2014) HMGB1 in Health and Disease. Molecular Aspects of Medicine, 40, 1-116.
[27] 王颖, 张立平, 孙宏峰, 等. 柴芪汤治疗肝郁脾虚型代谢综合征患者临床疗效观察[J]. 天津中医药, 2021, 38(9): 1133-1137.
[28] 陈恂. 柴芪汤通过细胞自噬改善代谢综合征血管内皮损伤的功效和机制研究[D]: [博士学位论文]. 北京: 北京中医药大学, 2020.[CrossRef] 
[29] 戴丛书, 高钰博, 李光耀, 等. 清肺泻肝汤对代谢综合征慢性炎症和血管内皮功能的影响[J]. 中国实验方剂学杂志, 2021, 27(5): 105-110. [Google Scholar] [CrossRef] 

为你推荐