基于昼夜节律角度探讨肠道稳态对炎症性肠病的影响

Effects of Intestinal Homeostasis on Inflammatory Bowel Disease Based on Circadian Rhythm

摘要: 炎症性肠病(inflammatory bowel disease, IBD)是一组病因不明肠道慢性炎性疾病，研究普遍认为其发生、发展涉及到具有潜在遗传易感性个体微生物失调、免疫及环境因素等之间复杂的相互作用。肠道稳态是宿主肠黏膜、肠道菌群、免疫屏障、营养及代谢产物等相互作用所构成的动态平衡状态。肠道稳态的破坏对于炎症性肠病发生、发展具有重要影响。肠道稳态的维持主要取决于3个关键因素，包括肠道菌群、肠道粘膜屏障和肠道免疫系统。这些因素中的任何一个方面失衡，都可能导致炎症性肠病。昼夜节律紊乱是炎症性肠病重要驱动因素，其导致肠道菌群破坏、肠道粘膜屏障受损及免疫异常。本文将就昼夜节律紊乱对于肠道稳态及炎症性肠病的影响展开综述，旨在为IBD的防治提供新的思路。

Abstract: Inflammatory Bowel Disease (IBD) is characterized by chronic non-specific intestinal inflammation, the etiology and pathogenesis of IBD remain largely unknown. It is generally thought that its oc-currence involves the complex interaction between individuals with potential genetic susceptibility, microbial imbalance, immunity and other factors. Intestinal homeostasis is a dynamic Balance state maintained by the integration of intestinal epithelial cells, intestinal bacteria, immune defense, Nutrition and metabolism. The disruption of intestinal homeostasis has a significant impact on the occurrence and development of inflammatory bowel disease. The maintenance of intestinal homeo-stasis mainly depends on three key factors, including intestinal flora, intestinal barrier and intesti-nal immune system. An imbalance in any one of these factors may lead to inflammatory bowel dis-ease. Circadian rhythm disorder is an important driving factor of inflammatory bowel disease, which leads to intestinal flora, intestinal barrier damage and immune abnormality .This article re-views the effects of circadian rhythm disorder on intestinal Imbalance and inflammatory bowel disease to attain new foreground for the prevention and treatment of IBD.