营心宁胶囊辅助治疗对冠心病心力衰竭患者血管紧张肽II水平和心功能的影响

Effect of Yingxinning Capsule Adjuvant Therapy on AngII Level and Cardiac Function in Patients with Coronary Heart Disease and Heart Failure

摘要: 目的：观察营心宁胶囊辅助治疗对冠心病心力衰竭患者血管紧张肽II (AngII)水平和心功能的影响。方法：将128例患者分为两组，对照组64例，治疗组64例。对照组予常规治疗，治疗组患者在此基础上加用营心宁胶囊治疗，每次4粒，每日3次。治疗前及治疗8周后检测血浆AngII、脑钠肽(BNP)，并行心脏彩色多普勒超声心动图测定左室射血分数(LVEF)、左室舒张末期内径(LVEDD)和每搏输出量(SV)。结果：治疗组和对照组总有效率分别为92.2%和89.1% (P > 0.01)；显效率分别为43.8%，32.8% (P < 0.01)。两组治疗后患者的AngII、BNP、LVEF、LVEDD和SV均较治疗前明显改善(P < 0.01或P < 0.05)，且治疗组患者的改善水平优于对照组(P < 0.01)。结论：营心宁胶囊能有效降低患者AngII水平，并对心功能有改善作用。

Abstract: Objective: To observe the effects of Yingxinning capsule adjuvant therapy on AngII level and cardiac function in patients with coronary heart disease and heart failure. Methods: 128 patients were di-vided into two groups: control group 64 cases, treatment group 64 cases. The control group was given conventional treatment, and the treatment group was additionally given Yingxinning capsule, 4 capsules each time, 3 times a day. Plasma AngII and BNP values were measured before and 8 weeks after treatment, and LVEF, LVEDD and SV were measured by color doppler echocardiography. Results: The total effective rate of treatment group and control group was 92.2% and 89.1%, with significant difference(P > 0.01).The significant efficiencies were 43.8% and 32.8%, with significant difference(P < 0.01). AngII, BNP, LVEF, LVEDD and SV of the two groups after treatment were signif-icantly improved compared with before treatment (P < 0.01 or P < 0.05), and the improvement lev-el of the treatment group was better than the control group, with significant difference (P < 0.01). Conclusion: Yingxinning capsule can effectively reduce the level of AngII and improve the cardiac function.