青光眼睫状体炎综合征的病因及治疗进展
Etiology and Treatment Progress of Posner-Schlossman Syndrome
DOI: 10.12677/ACM.2024.142481, PDF,    科研立项经费支持
作者: 娜日迪：内蒙古科技大学包头医学院，内蒙古 包头；杜红艳*：内蒙古自治区人民医院眼科，内蒙古 呼和浩特
关键词: 青光眼睫状体炎综合征；病因；治疗方法；Posner-Schlossman Syndrome； Pathogeny； Therapeutic Method
摘要: 光眼睫状体炎综合征(Posner-Schlossman Syndrome, PSS)是1948年Posner和Schlossman首次报道。它是一种轻度非肉芽肿性前葡萄膜炎，易复发，单侧眼发病居多，伴眼压升高、角膜后沉着物、疼痛及视力下降，也可出现视神经损害。PSS发病多与病毒感染有关，其病因复杂。目前认为与巨细胞病毒、单纯疱疹病毒、炎症、免疫遗传因素及血管内皮功能等有关。抗病毒、抗炎及控制眼压为目前主要治疗方法，药物治疗预后不良也可选择手术治疗，而目前病因及治疗方法仍有争议。本文通过研究PSS的病因及治疗方法从而对PSS临床诊断及治疗提供参考。
Abstract: Posner-Schlossman Syndrome was first reported by Posner and Schlossman in 1948. It is a mild non-granulomatous anterior uveitis prone to recurrence, unilateral eye disease, accompanied by increased intraocular pressure, posterior corneal accumulation, pain and vision loss, and can also appear optic nerve damage. The pathogeny of Posner-Schlossman Syndrome is more complicated than that of virus infection. Currently, it is thought to be related to cytomegalovirus, herpes simplex virus, inflammation, immune genetic factors and vascular endothelial function. At present, antiviral, anti-inflammatory and intraocular pressure control are the main treatment methods, and surgical treatment can also be selected for poor prognosis after drug treatment, but the cause and treat-ment method are still controversial. This paper studies the etiology and treatment of Posner- Schlossman syndrome to provide reference for clinical diagnosis and treatment of Posner- Schloss-man syndrome.
文章引用：娜日迪, 杜红艳. 青光眼睫状体炎综合征的病因及治疗进展[J]. 临床医学进展, 2024, 14(2): 3422-3428. https://doi.org/10.12677/ACM.2024.142481

参考文献

[1] Posner, A. and Schlossman, A. (1948) Syndrome of Unilateral Recurrent Attacks of Glaucoma with Cyclitic Symptoms. Archives of Ophthalmology, 39, 517-535. [Google Scholar] [CrossRef] [PubMed]
[2] Sheng, Q., Zhai, R., Fan, X., et al. (2021) The Analysis of Dynamic Changes and Prognosis of Posner-Schlossman Syndrome with Cytomegalovirus Infection and Antiviral Therapy. Journal of Ophthalmology, 2021, Article ID: 6687929. [Google Scholar] [CrossRef] [PubMed]
[3] Megaw, R. and Agarwal, P.K. (2016) Posner-Schlossman Syndrome. Survey of Ophthalmology, 62, 277-285. [Google Scholar] [CrossRef] [PubMed]
[4] Huq, M., Sanan, N., Daniels, P. and Hostoffer, R. (2020) Posner-Schlossman Syndrome in Common Variable Immunodeficiency. Case Reports in Ophthalmological Medicine, 2020, Article ID: 8843586. [Google Scholar] [CrossRef] [PubMed]
[5] Tsai, J.C. (2015) Detection of the Progression of Retinal Nerve Fiber Layer Loss by Optical Coherence Tomography in a Patient with Glaucomatocyclitic Crisis. Taiwan Journal of Ophthal-mology, 5, 90-93. [Google Scholar] [CrossRef] [PubMed]
[6] Garala, P. and Bansal, A. (2019) Acute Secondary Optic Neuropathy as a Complication of a Single Episode of Acutely Raised Intraocular Pressure: A Case Series. Journal of Glaucoma, 28, e10-e13. [Google Scholar] [CrossRef] 
[7] Chan, N., Chee, S.P., Caspers, L., et al. (2018) Clinical Fea-tures of CMV-Associated Anterior Uveitis. Ocular Immunology and Inflammation, 26, 107-115. [Google Scholar] [CrossRef] [PubMed]
[8] Bloch-Michel, E., Dussaix, E., Cerqueti, P. and Patarin, D. (1987) Possible Role of Cytomegalovirus Infection in the Etiology of the Posner-Schlossmann Syndrome. International Ophthalmology, 11, 95-96. [Google Scholar] [CrossRef] 
[9] Babu, K., Konana, V.K., Ganesh, S.K., et al. (2020) Viral Anterior Uvei-tis. Indian Journal of Ophthalmology, 68, 1764-1773. [Google Scholar] [CrossRef] 
[10] Okonkwo, O.N. and Tripathy, K. (2023) Posner-Schlossman Syndrome. StatPearls, Treasure Island.
[11] Sobolewska, B., Deuter, C., Doycheva, D. and Zierhut, M. (2014) Long-Term Oral Therapy with Valganciclovir in Patients with Posner-Schlossman Syndrome. Graefe’s Archive for Clinical and Experimental Ophthalmology, 252, 117-124. [Google Scholar] [CrossRef] [PubMed]
[12] Leleu, I., Jhanji, V., Touhami, S., et al. (2021) Clinical Features and Diagnosis of Anterior Segment Inflammation Related to Cytomegalovirus in Immunocompetent African, Asian, and Caucasian Patients. Ocular Immunology and Inflammation, 29, 160-168. [Google Scholar] [CrossRef] [PubMed]
[13] Hwang, Y.S., Shen, C.R., Chang, S.H.L., et al. (2011) The Validity of Clinical Feature Profiles for Cytomegaloviral Anterior Segment Infection. Graefe’s Archive for Clinical and Experimental Ophthalmology, 249, 103-110. [Google Scholar] [CrossRef] [PubMed]
[14] Tsirouki, T., Dastiridou, A., Symeonidis, C., et al. (2018) A Fo-cus on the Epidemiology of Uveitis. Ocular Immunology and Inflammation, 26, 2-16. [Google Scholar] [CrossRef] [PubMed]
[15] Igarashi, N., Honjo, M., Yamagishi, R., et al. (2020) In-volvement of Autotaxin in the Pathophysiology of Elevated Intraocular Pressure in Posner-Schlossman Syndrome. Scien-tific Reports, 10, Article No. 6265. [Google Scholar] [CrossRef] [PubMed]
[16] Igarashi, N., Honjo, M., Kaburaki, T. and Aihara, M. (2020) Ef-fects of ROCK Inhibitors on Apoptosis of Corneal Endothelial Cells in CMV-Positive Posner-Schlossman Syndrome Patients. Investigative Ophthalmology & Visual Science, 61, Article 5. [Google Scholar] [CrossRef] [PubMed]
[17] Wang, Q., Zeng, W., Zeng, W., et al. (2023) Risk Factors Associated with Corneal Endothelial Cell Density in Posner-Schlossman Syndrome. European Journal of Ophthalmology, 33, 1398-1404. [Google Scholar] [CrossRef] [PubMed]
[18] Yamamoto, S., Pavan-Langston, D., Tada, R., et al. (1995) Pos-sible Role of Herpes Simplex Virus in the Origin of Posner-Schlossman Syndrome. American Journal of Ophthalmology, 119, 796-798. [Google Scholar] [CrossRef] 
[19] Hong, Y., Wang, M. and Wu, L. (2017) In Vivo Confocal Microscopy of Posner-Schlossman Syndrome: Comparison with Herpes Simplex Keratitis, HLA-B27 Anterior Uveitis and Acute Attack of Primary Angle Closure. Scientific Reports, 7, Article No. 9832. [Google Scholar] [CrossRef] [PubMed]
[20] 陈文杰, 赵军, 祝天辉, 等. 青光眼睫状体炎综合征患者5种常见病原微生物相关血清抗体的测定及分析[J]. 中华实验眼科杂志, 2017, 35(12): 1115-1119.
[21] Rodier-Bonifas, C., Cornut, P.L., Billaud, G., et al. (2010) Cytomegalovirus Research Using Polymer-ase Chain Reaction in Posner-Schlossman Syndrome. Journal Français d’Ophtalmologie, 34, 24-29. [Google Scholar] [CrossRef] [PubMed]
[22] Knox, D.L. (1988) Glaucomatocyclitic Crises and Systemic Disease: Peptic Ulcer, Other Gastrointestinal Disorders, Allergy and Stress. Transactions of the American Ophthalmological So-ciety, 86, 473-495.
[23] Demailly, P., Zaegel, R., Blamoutier, J., et al. (1985) Syndrome De Posner Schlossmann et Al-lergie. Journal Français d’ophtalmologie, 8, 773-777.
[24] Huang, X., Liu, X., Ye, Y., et al. (2021) Polymorphisms and Circulating Plasma Protein Levels of Immune Checkpoints (CTLA-4 and PD-1) Are Associated with Pos-ner-Schlossman Syndrome in Southern Chinese. Frontiers in Immunology, 12, Article 607966. [Google Scholar] [CrossRef] [PubMed]
[25] Zhao, J., Zhu, T., Chen, W., et al. (2015) Human Leukocyte An-tigens-B And-C Loci Associated with Posner-Schlossman Syndrome in a Southern Chinese Population. PLOS ONE, 10, e0132179. [Google Scholar] [CrossRef] [PubMed]
[26] 李灿, 李苹, 李筱芹. 应用彩色多普勒血流动力学检查对多种青光眼的观察[J]. 眼科新进展, 2002, 22(4): 253-255.
[27] Su, W.W., Cheng, S.T., Ho, W.J., et al. (2008) Glau-coma Is Associated with Peripheral Vascular Endothelial Dysfunction. Ophthalmology, 115, 1173-1178. E1. [Google Scholar] [CrossRef] [PubMed]
[28] Dascalu, A.M., Stana, D., Nicolae, V.A., et al. (2021) Associa-tion between Vascular Comorbidity and Glaucoma Progression: A Four-Year Observational Study. Experimental and Therapeutic Medicine, 21, Article No. 283. [Google Scholar] [CrossRef] [PubMed]
[29] Nutterová, E., Pitrová, Š. and Lešták, J. (2020) Our Experience with Micropulse Cyclophotocoagulation in the Therapy of Glaucoma. Ceska a Slovenska Oftalmologie, 76, 29-36.
[30] 魏宇娇, 张丽霞, 倘孟莹, 等. 基于“天人同律”辨治青光眼睫状体炎综合征[J]. 中华中医药杂志, 2022, 37(7): 3939-3942.
[31] 刘小猫, 袁灵梅, 占欢腾. 青睫症方治疗青光眼睫状体炎综合征临床观察[J]. 中国中医药现代远程教育, 2022, 20(11): 88-90.
[32] 吴春宏, 梁秀栋, 赖俏群. 熊胆开明片联合地塞米松和噻吗洛尔滴眼剂治疗青光眼睫状体炎综合征的临床疗效[J]. 中国处方药, 2022, 20(5): 58-60.
[33] Tripathy, K. and Geetha, R. (2023) Latanoprost. StatPearls, Treasure Island.
[34] Shazly, T.A., Aljajeh, M. and Latina, M.A. (2011) Posner-Schlossman Glaucomatocyclitic Crisis. Seminars in Ophthalmology, 26, 282-284. [Google Scholar] [CrossRef] [PubMed]
[35] Antoun, J., Willermain, F., Makhoul, D., et al. (2017) Topical Ganciclovir in Cytomegalovirus Anterior Uveitis. Journal of Ocular Pharmacology and Therapeutics, 33, 313-318. [Google Scholar] [CrossRef] [PubMed]
[36] 许欢, 翟如仪, 孔祥梅, 等. 青光眼睫状体炎综合征患者房水病毒情况分析[J]. 中国眼耳鼻喉科杂志, 2018, 18(1): 18-21.
[37] Artini, W. and Bani, A.P. (2019) The Effectiveness of Trabeculectomy with Mitomycin C and Releasable Suture in Posner-Schlossman Syndrome with Secondary Glaucoma: A Case Series. Nigerian Journal of Clinical Practice, 22, 138-143. [Google Scholar] [CrossRef] [PubMed]
[38] Wadke, V., Lingam, V., George, R., et al. (2019) Phacotrabeculec-tomyin Eyes with Uveitic Glaucoma: A Retrospective Case-Control Study. Journal of Glaucoma, 28, 606-612. [Google Scholar] [CrossRef] 
[39] Maruyama, K., Maruyama, Y., Sugita, S., et al. (2017) Char-acteristics of Cases Needing Advanced Treatment for Intractable Posner—Schlossman Syndrome. BMC Ophthalmology, 17, Article No. 45. [Google Scholar] [CrossRef] [PubMed]
[40] Murata, K., Ishida, K., Ozawa, K., et al. (2019) The Characteris-tics of Posner-Schlossman Syndrome: A Comparison in the Surgical Outcome between Cytomegalovirus-Positive and Cytomegalovirus-Negative Patients. Medicine, 98, e18123. [Google Scholar] [CrossRef] 
[41] Broadway, D.C., Bates, A.K., Lightman, S.L., et al. (1993) The Importance of Cellular Changes in the Conjunctiva of Patients with Uveitic Glaucoma Undergoing Trabeculectomy. Eye, 7, 495-501. [Google Scholar] [CrossRef] [PubMed]
[42] Mercieca, K., Steeples, L. and Anand, N. (2017) Deep Sclerectomy for Uveitic Glaucoma: Long-Term Outcomes. Eye, 31, 1008-1019. [Google Scholar] [CrossRef] [PubMed]
[43] Pahlitzsch, M., Torun, N., Gonnermann, J., et al. (2015) Trabeculectomy Ab Interno (Trabectome): Yet another Possibility in the Treatment of Uncontrolled Glaucomatocyclitic Crisis under Sys-temic Valganciclovir Therapy? Eye, 29, 1335-1339. [Google Scholar] [CrossRef] [PubMed]

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