BR  >> Vol. 1 No. 2 (July 2012)

    Calcineurin B-Like Proteins and Their Interacting Protein Kinases

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Ca2+作为第二信使介导大量的信号传递,在许多生命过程中发挥重要的作用。Ca2+信号通过Ca2+感受器即Ca2+结合蛋白来解码并传递。类钙调磷酸酶B蛋白CBL(Calcineurin B-like protein)便是其中一类Ca2+结合蛋白。通过与其特定的激酶蛋白CIPK(CBL-interacting protein kinase)作用,在Ca2+信号传导通路,尤其是一些逆境信号传导通路中发挥重要作用。本文主要围绕CBL和它们的作用蛋白CIPK,在其结构、功能以及它们如何对信号做出不同反应的机制上对一些已经得到的共识和最新获得的成果进行概述。

Calcium is a critical messenger in several biological processes. Cellular calcium signals are de-tected and transmitted by Ca2+ sensor such as calcium-binding proteins. Calcineurin B-like protein (CBL) family represents a group of such calcium sensors and plays a key role in decoding calcium signals by spe-cifically interacting with and regulating a family of protein kinases CIPKs(for CBL-interacting protein kinases). Many researches have revealed that several CBL proteins and CIPKs are important components of abiotic stress responses and ion transport processes. Here, we discuss structures and functions of CBLs and CIPKs and how specific Ca2+ signal responds are realized.

沈清, 郭万里, 蒋立希. 类钙调神经磷酸酶B亚基蛋白CBL和它们的作用激酶蛋白CIPK[J]. 植物学研究, 2012, 1(2): 9-12.


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