BR  >> Vol. 1 No. 2 (July 2012)

    Calcineurin B-Like Proteins and Their Interacting Protein Kinases

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Ca2+作为第二信使介导大量的信号传递,在许多生命过程中发挥重要的作用。Ca2+信号通过Ca2+感受器即Ca2+结合蛋白来解码并传递。类钙调磷酸酶B蛋白CBL(Calcineurin B-like protein)便是其中一类Ca2+结合蛋白。通过与其特定的激酶蛋白CIPK(CBL-interacting protein kinase)作用,在Ca2+信号传导通路,尤其是一些逆境信号传导通路中发挥重要作用。本文主要围绕CBL和它们的作用蛋白CIPK,在其结构、功能以及它们如何对信号做出不同反应的机制上对一些已经得到的共识和最新获得的成果进行概述。

Calcium is a critical messenger in several biological processes. Cellular calcium signals are de-tected and transmitted by Ca2+ sensor such as calcium-binding proteins. Calcineurin B-like protein (CBL) family represents a group of such calcium sensors and plays a key role in decoding calcium signals by spe-cifically interacting with and regulating a family of protein kinases CIPKs(for CBL-interacting protein kinases). Many researches have revealed that several CBL proteins and CIPKs are important components of abiotic stress responses and ion transport processes. Here, we discuss structures and functions of CBLs and CIPKs and how specific Ca2+ signal responds are realized.

沈清, 郭万里, 蒋立希. 类钙调神经磷酸酶B亚基蛋白CBL和它们的作用激酶蛋白CIPK[J]. 植物学研究, 2012, 1(2): 9-12.


[1] A. N. Dodd, J. Kudla and D. Sanders. The language of calcium signaling. Annual Review of Plant Biology, 2010, 61: 593-620.
[2] P. J. White, M. R. Broadley. Calcium in plants. Annals of Botany, 2003, 92(4): 487-511.
[3] Q. Liu, M. Kasuga, Y. Sakuma, et al. Two transcription factors, DREB1and DREB2, with an EREBP/AP2 DNA binding domain separate two cellular signal transduction pathways in drought- and low-temperature-in drought- and low-temperature-responsive gene expression, respectively, in Arabidopsis. Plant Cell, 1998, 10(8): 1391-1406.
[4] J. Kudla, Q. Xu, K. Harter, et al. Genes for calcineurin B-like proteins in Arabidopsis are differentially regulated by stress signals. Proceedings of the National Academy of Sciences of USA, 1999, 96(8): 4718-4723.
[5] S.-I. Oh, J. Y. Park, S. H. Yoon, et al. The arabidopsis calcium sensor calcineurin B-like 3 inhibits the 5’-methylthioadenosine nucleosidase in a calcium-dependent manner. Plant Physiology, 2008, 148(4): 1883-1896.
[6] S. Luan, J. Kudla, M. Rodriguez-Concepcion, et al. Calmodulins and calcineurin B-like proteins: Calcium sensors for specific signal response coupling in plants. Plant Cell, 2002, 14: S389- S400.
[7] U. Kolukisaoglu, S. Weinl, D. Blazevic, et al. Calcium sensors and their interacting protein kinases: Genomics of the Arabidopsis and rice CBL-CIPK signaling networks. Plant Physiology, 2004, 134(1): 43-58.
[8] O. Batistič, J. Kudla. Plant calcineurin B-like proteins and their interacting protein kinases. Biochimica et Biophysica Acta, 2009, 1793(6): 985-992.
[9] M. Ishitani, J. Liu, U. Halfter, et al. SOS3 function in plant salt tolerance requires N-myristoylation and calcium binding. Plant Cell, 2000, 12: 1667-1678.
[10] O. Batistic, N. Sorek, S. Schultke, et al. Dual fatty acyl modification determines the localization and plasma membrane targeting of CBL/CIPK Ca2+ signaling complexes in arabidopsis. Plant Cell, 2008, 20: 1346-1362.
[11] B. G. Kim, R. Waadt, Y. H. Cheong, et al. The calcium sensor CBL10 mediates salt tolerance by regulating ion. The Plant Journal, 2007, 52(3): 473-484.
[12] S. Luan, J. Kudla, M. Rodrigyez-Concepcion, et al. Calmodulins and calcineurin B-like proteins: Calcium sensors for specific signal response coupling in plants. The Plant Cell, 2002, 14, 389-400.
[13] U. Halfter, M. Ishitani and J. K. Zhu. The arabidopsis SOS2 protein kinase physically interacts with and is activated by the calcium-binding protein SOS3. Proceedings of the National Academy of Sciences of USA, 2000, 97(7): 3735-3740.
[14] Q. S. Qiu, Y. Guo, M. A. Dietrich, et al. Regulation of SOS1, a plasma membrane Na+/H+ exchanger in Arabidopsis thaliana, by SOS2 and SOS3. Proceedings of the National Academy of Sciences of USA, 2002, 99(12): 8436-8441.
[15] F. J. Quintero, M. Ohta, H. Shi, et al. Reconstitution in yeast of the Arabidopsis SOS signaling pathway for Na+ homeostasis. Proceedings of the National Academy of Sciences of USA, 2002, 99(13): 9061-9066.
[16] J. Rivandi, J. Miyazaki, M. Hrmova, et al. A sos3 homologue maps to HvNax4, a barley locus controlling an environmentally sensitive Na+ exclusion trait. Journal of Experimental Botany, 2010, 62(3): 1201-1216.
[17] V. Albrecht, S. Weinl, D. Blazevic, et al. The calcium sensor CBL1 integrates plant responses to abiotic stresses. The Plant Journal, 2003, 36(4): 457-470.
[18] B. J. Ma, Z. Gu, H. J. Tang, et al. Preliminary study on function of calcineurin B-like protein gene OsCBL8 in rice. Rice Science, 2010, 17(1): 10-18.
[19] Y. Hwang, C. B. Paul, Y. H. Cheong, et al. A gibberellin-regu- lated calcineurin B in rice localizes to the tonoplast and is implicated in vacuole function. Plant Physiology, 2005, 138(3): 1347-1358.
[20] K. P. Girdhar, J. J. Grant, Y. H. Cheong, et al. Calcineurin- B-like protein CBL9 interacts with target kinase CIPK3 in the regulation of ABA response in seed germination. Molecular Plant, 2008, 1(2): 238-248.