PSMA PET/CT和PET/MRI在前列腺癌初始分期中的作用

The Role of PSMA PET/CT and PET/MRI in the Initial Staging of Prostate Cancer

摘要: 前列腺癌(PCa)是男性最常见的实体器官恶性肿瘤，也是导致癌症死亡的第三大原因。准确的PCa检测和分期方法是确定疾病程度和治疗方案的必要条件。回顾前列腺特异性膜抗原(PSMA)正电子发射断层扫描(PET)成像在PCa初步分期中的表现和诊断准确性，并评估其对明确治疗计划的影响。与传统成像相比，PSMA PET对检测前列腺内肿瘤具有中等程度的高灵敏度和特异性，对检测区域和盆腔外转移瘤具有中等程度的高灵敏度。PSMA PET还可在手术前检测前列腺外疾病方面发挥重要作用，并可指导手术规划。此外，PSMA PET已被证明是对治疗无效患者进行明确放疗计划的有效工具。因此，回顾了前列腺特异性膜抗原(PSMA)正电子发射断层扫描(PET)成像在前列腺癌(PCa)初始分期中的诊断准确性和对治疗的影响。我们得出结论：PSMA正电子发射计算机断层成像能有效地对初期PCa进行成像，并能帮助患者修改治疗方案。

Abstract: Prostate cancer (PCa) is the most common solid organ malignancy in men and the third leading cause of cancer death. Accurate PCa detection and staging methods are essential for determining the extent of disease and treatment options. Review prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging in Performance and diagnostic accuracy in PCa initial staging, and to assess its impact on a definitive treatment plan. Compared to conventional imaging, PSMA PET has moderately high sensitivity and specificity for detecting intraprostate tumors and moderately high sensitivity for detecting regional and extra-pelvic metastases. PSMA PET can also play an important role in detecting extra-prostatic disease before surgery and can guide surgical planning. In addition, PSMA PET has proven to be an effective tool for a definitive radiotherapy plan for patients who have not responded to treatment. Therefore, the diagnostic accuracy and impact on treatment of prostate specific membrane antigen (PSMA) positron emission tomography (PET) im-aging in the initial staging of prostate cancer (PCa) were reviewed. We conclude that PSMA positron emission computed tomography is effective in imaging initial PCa and can help patients modify treatment.