缺血性脑白质高信号与血管性认知障碍关系的研究进展
Advances in the Relationship between Ischemic White Matter Hyperintensity and Vascular Cognitive Impairment
摘要: 缺血性脑白质高信号(WMH)是脑小血管病(CSVD)的影像学表现之一，近年来研究发现，缺血性WMH可导致认知功能下降、运动功能障碍、增加卒中后抑郁和二便障碍的风险。其中早期认知功能的损害表现不突出，然而影响患者后期的生存质量。因此，研究缺血性WMH患者发生认知障碍的潜在机制显得尤为重要。本文主要阐述两者之间关系，并从病理生理学、影像学、生物标志物三个方面对其机制进行总结，以期为预防缺血性WMH患者发生认知障碍提供新思路。
Abstract: Ischemic white matter hyperintensity (WMH) of presumed vascular origin is one of the imaging markers of cerebral small vascular disease (CSVD). Recent studies show that ischemic WMH may be a risk factor for the occurrence of cognitive impairment, motor dysfunction, and increased risk of post-stroke depression and defecation disorder. Among them, the impairment of early cognitive function is not prominent, but it affects the later quality of life of patients. Therefore, it is particu-larly important to investigate the underlying mechanisms of cognitive dysfunction in patients with ischemic WMH. This paper reviewed the current state of research on the mechanisms of cognitive impairment in the development of ischemic WMH from pathology, imaging and biology, in order to provide new ideas for preventing cognitive impairment caused by ischemic WMH.
文章引用：王颖颖, 王蓉蓉, 赵雄飞. 缺血性脑白质高信号与血管性认知障碍关系的研究进展[J]. 临床医学进展, 2024, 14(3): 438-444. https://doi.org/10.12677/ACM.2024.143721

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