顺铂肾毒性损伤机制的研究进展

Research Advancement on Cisplatin-Induced Nephrotoxicity

摘要: 顺铂(Cisplatin, DDP)是临床常用的细胞周期非特异性化疗药物，主要用于肺癌、睾丸癌、卵巢癌、膀胱癌、头颈部肿瘤等实质性恶性肿瘤的一线治疗。临床研究发现，DDP抗肿瘤作用的疗效与其用药剂量呈正相关，然而DDP剂量依赖性的肾毒性作用极大限制了其临床应用。但是剂量依赖性肾毒性作用极大限制了DDP的临床应用。至今为止DDP肾毒性损伤的作用机制尚不清楚，同时临床上也无可靠的、特异性的治疗方法。本文就DDP肾毒性损伤的变化和可能发生机制及其治疗对策进行综述，为进一步研究奠定基础。

Abstract: Cisplatin (DDP) is a cell cycle non-specific antineoplastic drug, which is generally preferred used for treating solid malignant tumors, including those originated in the head, neck, lung, testis, ovary, breast etc. It has been found that the antitumor effects of DDP were correlated with its dose; however, DDP-induced dose-dependent renal toxicity greatly limits its clinical application. Up to now the exact mechanism of nephrotoxicity induced by DDP remains un- known, and there were also no reliable and specific methods for treating or preventing DDP-induced acute renal injury yet. The information gleaned from this review may provide the changes and possible mechanism of DDP-induced nephrotoxicity and its therapeutic strategy for further research.