2-氯甲基-3,5-二甲基-4-甲氧基吡啶的合成及分析

Synthesis and Analysis of 2-Chloromethyl-3,5-Dimethyl-4-Methoxypyridine

摘要: 以2,3,5-三甲基吡啶为起始原料，经N-氧化、硝化、亲核取代、重排水解和氯甲基化等五大步骤而制得2-氯甲基-3,5-二甲基-4-甲氧基吡啶的合成与工艺。并通过¹HNMR、FT-IR、HPLC等测试手段对2-氯甲基-3,5-二甲基-4-甲氧基吡啶产品进行定性和定量分析。

Abstract: 2-Chloromethyl-3,5-dimethyl-4-methoxypyridine was synthesized by use of 2,3,5-trimethylpyridine as the starting material. The synthetic route contains five steps including N-oxidation, nitration, nu-cleophilic substitution, alcoholation and chloromethylation. The target product was qualitatively and quantitatively analyzed using ¹H NMR, FT-IR, and HPLC testing methods.