猪肠粘膜中肝素钠提取技术的研究现状和发展趋势
Research Status and Development Trend of Extraction Technology of Crude Heparin Sodium
摘要: 肝素钠是肝素的钠盐，具有非常大的医学和生物学价值，肝素临床应用范围逐渐扩大，用药患者群体也逐渐增加，进而带动全球肝素类药品市场扩大和粗品肝素钠需求增长。论文基于国内外粗品肝素钠提取技术的发展现状，综合评价了提取粗品肝素钠工艺，并对国内粗品肝素钠的发展趋势进行展望。
Abstract: Heparin sodium is the sodium salt of heparin, which has great medical and biological value. The clinical application of heparin has gradually expanded, and the population of drug users has gradually increased, which has led to the expansion of the global heparin drug market and the growth of the demand for crude heparin sodium. Based on the development status of crude heparin sodium extraction technology at home and abroad, the extraction process of crude heparin sodium was comprehensively evaluated, and the development trend of crude heparin sodium at home was prospected.
文章引用：舒顺顺, 米倩, 韩成荣, 张凤云, 汤尚文, 牛军. 猪肠粘膜中肝素钠提取技术的研究现状和发展趋势[J]. 亚洲兽医病例研究, 2019, 8(1): 1-8. https://doi.org/10.12677/ACRPVM.2019.81001

参考文献

[1] St, A.K., Onishi, A., Fu, L., et al. (2016) Analysis of Heparins Derived from Bovine Tissues and Comparison to Porcine Intestinal Heparins. Clinical and Applied Thrombosis/Hemostasis, 22, 520. [Google Scholar] [CrossRef] [PubMed]
[2] Papa, A., Danese, S., Gasbarrini, A., et al. (2000) Review Article: Potential Therapeutic Applications and Mechanisms of Action of Heparin in Inflammatory Bowel Disease. Alimentary Pharmacology and Therapeutics, 14, 1403-1409. [Google Scholar] [CrossRef] [PubMed]
[3] 董斌, 朱宇, 吴丹, 等. 肝素泵在血液透析中的临床应用与故障处理[J]. 中国医学装备, 2018(2): 132-134.
[4] 彭向宇. 百特事件后我国肝素企业首位度分析[J]. 肉类工业, 2014(2): 52-53.
[5] 刘文涛, 顾立伟. 关于中国与美国养猪业的比较研究[J]. 中国畜牧杂志, 2016, 52(6): 3-7.
[6] 荣嫡. 肝素类: 出口量价齐跌逼产业加速升级[N]. 医药经济报, 2014-03-10(006).
[7] 徐俊涛, 翟海港, 方永卫, 等. 肝素钠吸附提取工艺优化研究[J]. 肉类工业, 2018(2): 31-34.
[8] 王忠民. 猪小肠生产肝素钠新工艺[J]. 农村经济与科技, 2000, 11(5): 43-43.
[9] Yates, E.A. and Rudd, T.R. (2016) Recent Innovations in the Structural Analysis of Heparin. International Journal of Cardiology, 212, S5-S9. [Google Scholar] [CrossRef] 
[10] Lim, G.B. (2017) Milestone 1: Discovery and Purification of Heparin. Nature Reviews Cardiology. [Google Scholar] [CrossRef] [PubMed]
[11] James, A.M. (1997) The Development of Heparin in Toronto. Journal of the History of Medicine and Allied Science, 52, 310-337. [Google Scholar] [CrossRef] [PubMed]
[12] Tahir, R. (2007) A Review of Unfractionated Heparin and Its Moni-toring. U.S. Pharmacist, 32, 26-36.
[13] 何为贵, 潘启超. 肝素抗凝机制研究的进展及其临床应用[J]. 国外医学(内科学分册), 1983(8): 384-388.
[14] Rosenberg, R.D. and Damus, P.S. (1973) The Purification and Mechanism of Action of Human Antithrombin-Heparin Cofactor. Journal of Biological Chemistry, 248, 6490-6505.
[15] Middeldorp, S. (2008) Heparin: From Animal Organ Extract to Designer Drug. Thrombosis Research, 122, 753-762. [Google Scholar] [CrossRef] [PubMed]
[16] Janytzen, V.D.M., Kellenbach, E. and Van Den Bos, L.J. (2017) From Farm to Pharma: An Overview of Industrial Heparin Manufacturing Methods. Molecules, 22, 1025. [Google Scholar] [CrossRef] [PubMed]
[17] Keire, D., Mulloy, B., Chase, C., et al. (2015) Diversifying the Global Heparin Supply Chain: Reintroduction of Bovine Heparin in the United States? Pharmaceutical Technology, 28, 36.
[18] 张培蕾, 周耕, 程永德. 肝素诱导性血小板减少症相关研究进展[J]. 介入放射学杂志, 2017, 26(5): 385-389.
[19] 张晓娟, 熊双丽, 钟雨婷. 猪肺肝素钠提取工艺优化、分离与初步鉴定[J]. 精细化工, 2014, 31(5): 597-602.
[20] Bett, C., Grgac, K., Long, D., et al. (2017) A Heparin Purification Process Removes Spiked Transmissi-ble Spongiform Encephalopathy Agent. The AAPS Journal, 19, 765-771. [Google Scholar] [CrossRef] [PubMed]
[21] Vreeburg, J.W. and Baauw, A. (2009) Method for Preparation of Heparin from Mucosa. Patent No. WO2010/110654 A1.
[22] 马志科, 马丽. 动物器官中肝素钠提取方法研究进展[J]. 动物医学进展, 2016, 37(5): 106-108.
[23] 汤彬彩, 童永刚, 潘卫春, 等. 复合酶酶解肝素钠的工艺研究[J]. 现代化工, 2015, 35(3): 98-100.
[24] 董浩, 丁凌霄, 罗志良, 等. 酶法与膜分离结合高效提取肝素钠的工艺研究[J]. 食品工业, 2014(9): 158-160.
[25] 于海宁, 张鹏, 陶艳红, 等. 固定化酶解猪小肠黏膜制备肝素的工艺研究[J]. 天然产物研究与开发, 2016, 28(2): 300-306.
[26] 杨涛, 万端极, 吴正奇, 邹华荣, 马超. 肝素粗品提取新工艺研究[J]. 食品研究与开发, 2015, 36(2): 52-55.
[27] 童永刚, 汤彬彩, 马青青, 等. 粗品肝素钠吸附工艺的优化研究[J]. 应用化工, 2015, 44(12): 2289-2292.
[28] 姬胜利, 桑青, 张天民. 肝素的来源控制、结构分析以及结构与生物活性关系的研究进展[J]. 中国药学杂志, 2012, 22(9): 660-663.
[29] 罗喜牛, 沈静, 王新昌. 肝素钠粗品生产工艺[J]. 中国医药工业杂志, 1999, 30(5): 202-205.
[30] 李红心. 肝素钠的精制及效价分析[J]. 山西大学学报(自然科学版), 2005, 28(4): 429-431.
[31] 徐俊涛, 王玉芬, 谢华, 等. 粗品肝素钠精制工艺优化研究[J]. 食品与机械, 2012, 28(4): 206-208.
[32] 王国栋, 杨佳艺, 杨佳, 等. 肝素提取纯化技术研究进展[J]. 食品工业科技, 2012, 33(9): 436-440.
[33] 宋大巍, 刘昆, 张丽萍. 酶法结合D500大孔树脂分离纯化粗品肝素[J]. 中国生物制品学杂志, 2016, 29(3): 292-299.
[34] 翟建, 姜春华, 鲁秀国. 肠衣–肝素钠加工废水处理技术进展[J]. 食品工业, 2013, 34(8): 192-194.
[35] 马彦峰. 肝素钠废水水质解析[J]. 科技创新与应用, 2015(15): 61-62.
[36] 杨红薇, 陈佼, 何婷. SBR法处理高盐肝素废水运行参数优化研究[J]. 工业安全与环保, 2015, 41(2): 7-9.
[37] 杨红薇, 陈佼, 张建强. K+、Ca2+、Mg2+对高盐肝素废水处理的影响[J]. 环境工程学报, 2014, 8(10): 4267-4272.
[38] 杨红薇, 罗芳林, 郭天明. Zn2+、Mn2+对SBR工艺处理高盐肝素废水的影响[J]. 工业水处理, 2017, 37(8): 20-24.
[39] 杨彬, 孙军锋, 武梦言, 等. 肝素钠生产废水处理及蛋白回收[J]. 环境科学研究, 2016, 29(9): 1385-1392.
[40] 汤彬彩, 童永刚, 潘卫春, 等. 从肝素副产物废蛋白中提取类肝素工艺研究[J]. 现代化工, 2015(11): 125-128.
[41] Onishi, A., St, A.K., Dordick, J.S., et al. (2016) Heparin and Anticoagulation. Frontiers in Bioscience, 21, 1372-1392. [Google Scholar] [CrossRef] [PubMed]

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