手性药物拆分的新进展及未来发展方向
New Progress and Future Development of Chiral Drug Resolution
DOI: 10.12677/HJCET.2019.96062, PDF,    国家自然科学基金支持
作者: 郑 爽, 王诗梦：锦州医科大学，第一临床医学院，辽宁 锦州；缪馨漫：锦州医科大学，基础医学院，辽宁 锦州；杨殿深, 付纯刚, 钱 昆*：锦州医科大学，公共基础学院，辽宁 锦州
关键词: 手性药物的拆分；聚整体柱毛细管电泳；薄层色谱法；分子印迹复合膜；Resolution of Chiral Drugs； Polymer Monolithic Capillary Electrophoresis； Thin Layer Chromatography； Molecularly Imprinted Composite Membrane
摘要: 手性作为自然界的一种常见的物理现象，普遍存在于生物体中。手性物质的结构就像左右手一样能重合，而又存在着一些差异。由于手性分子的空间立体结构不同，两种化合物可能表现出具有显著差异的化学性质。这会影响反应效率，反应活性，甚至药性和毒性。目前知网中收录了关于手性药物的文献有715篇，其中关于手性拆分方法的文献仅有114篇。这里叙述了几种当前热门的拆手性分方法，简单介绍了手性药物在医药领域的重要性，概述近年来手性药物拆分方法的优缺点，整理了最新的研究提取及制备手性药物的文献，希望为研究手性药物略尽绵薄之力。
Abstract: Chirality, as a common physical phenomenon in nature, is ubiquitous in organisms. The structure of chiral substances can overlap like the left and right hands, but there are some differences. Because of the different stereoscopic structures of chiral molecules, the two compounds may exhibit significant differences in chemical properties. This will affect the reaction efficiency, reactivity, and even pharmacology and toxicity. At present, there are 715 articles about chiral drugs in CNKI (China National Knowledge Infrastructure), of which only 114 are about chiral resolution methods. This paper describes several popular chiral separation methods, briefly introduces the importance of chiral drugs in the field of medicine, summarizes the advantages and disadvantages of chiral drug separation methods in recent years, and collates the latest research literature on extraction and preparation of chiral drugs, hoping to make a little contribution to the study of chiral drugs.
文章引用：郑爽, 王诗梦, 缪馨漫, 杨殿深, 付纯刚, 钱昆. 手性药物拆分的新进展及未来发展方向[J]. 化学工程与技术, 2019, 9(6): 435-443. https://doi.org/10.12677/HJCET.2019.96062

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