脊髓损伤后神经源性膀胱的康复治疗进展
Progress in Rehabilitation Treatment of Neurogenic Bladder after Spinal Cord Injury
摘要: 神经源性膀胱(neurogenic bladder, NB)是脊髓损伤(spinal cord injury, SCI)的临床常见合并症之一。膀胱功能障碍引起的肾功能衰竭是脊髓损伤患者死亡的第一位原因。因此,重建平衡的膀胱功能和提高控尿能力是脊髓损伤患者康复治疗中一项重要内容,对于提高患者生活质量,延长预期寿命具有重要的意义。神经源性膀胱的康复治疗包括药物疗法、手术疗法、电刺激疗法、磁刺激疗法以及康复训练疗法等。尿流动力学检查已成为脊髓损伤后膀胱尿道功能障碍的常规检查技术,通过尿流动力学检查可对膀胱尿道功能进行分类外,还可为临床的诊断、治疗及疗效评价提供更多的客观指标。本文将近些年来脊髓损伤后神经源性膀胱康复治疗研究的成果进行概述,总结出脊髓损伤后神经源性膀胱的治疗是复杂的综合工作,间歇性导尿、膀胱功能训练等已经是比较成熟的治疗手段,但目前仍没有一种方法可以使神经源性膀胱功能完全恢复。
Abstract: Neurogenic bladder is one of clinical common complication of spinal cord injury. To improve the patients’ quality of life and reduce mortality, reconstruction of spinal cord injury patients with bladder function has important significance. NB rehabilitation treatment includes rehabilitation training therapy, drug therapy, electrical stimulation therapy, magnetic stimulation therapy, etc. Urodynamic testing has become a routine inspection of bladder dysfunction after spinal cord injury, neurogenic bladder can be categorize through the test, besides, it still can provide more objective indicators of clinical diagnosis, treatment and curative effect evaluation. This article is to summarize the latest research results of rehabilitation in spinal cord injury. Various treatments for neurogetic bladder were introduced and their treatment results were critically reviewed. Summarily, the treatment of neurogenic bladder after spinal cord injury is an integrated and complex work, which no satisfying treatment is available. Bladder function training and intermittent catheterization are common method.
文章引用:宋晨, 李江, 徐子涵, 丛小萌, 李闻宇. 脊髓损伤后神经源性膀胱的康复治疗进展[J]. 临床医学进展, 2020, 10(12): 3201-3208. https://doi.org/10.12677/ACM.2020.1012479

参考文献

[1] Li, J., Liu, G., Zheng, Y., Hao, C., Zhang, Y., Wei, B., Zhou, H. and Wang, D. (2011) The Epidemiological Survey of Acute Traumatic Spinal Cord Injury (ATSCI) of 2002 in Beijing Municipality. Spinal Cord, 49, 777-782.
[Google Scholar] [CrossRef] [PubMed]
[2] Samson, G. and Cardenas, D.D. (2007) Neurogenic Bladder in Spinal Cord Injury. Physical Medicine and Rehabilitation Clinics of North America, 18, 255-274.
[Google Scholar] [CrossRef] [PubMed]
[3] Griffiths, D. (2015) Neural Control of Micturition in Humans: A Working Model. Nature Reviews Urology, 12, 695-705.
[Google Scholar] [CrossRef] [PubMed]
[4] Nour, S., Svarer, C., Kristensen, J.K., Paulson, O.B. and Law, I. (2000) Cerebral Activation during Micturition in Normal Men. Brain, 123, 781-789.
[Google Scholar] [CrossRef] [PubMed]
[5] 鹿尔训, 沈稚舟, 方天祥, 等. 临床神经泌尿学[M]. 北京: 人民卫生出版社, 1984: 220-229.
[6] Cravens, D.D. and Zweig, S. (2000) Urinary Catheter Management. American Family Physician, 61, 369-376.
[7] Dorsher, P.T., Reimer, R. and Nottmeier, E. (2009) Treatment of Urinary Incontinence Due to Incomplete Spinal Cord Injury with Acupuncture and Percutaneous Electrical Nerve Stimulation: Two Cases and Literature Review. Medical Acupuncture, 3, 21-26.
[Google Scholar] [CrossRef
[8] Bjerklund, J.T.E., Cek, M., Naber, K., et al. (2007) Prevalence of Hospital-Acquired Urinary Tract Infections in Urology Departments. European Urology, 51, 1100-1111.
[Google Scholar] [CrossRef] [PubMed]
[9] Elizabeth, L. (2019) Medical Management of Neurogenic Bladder for Children and Adults: A Review. Topics in Spinal Cord Injury Rehabilitation, 25, 195-204.
[Google Scholar] [CrossRef] [PubMed]
[10] Hall, B. and Woodward, S. (2015) Pelvic Floor Muscle Training for Urinary Incontinence Postpartum. British Journal of Nursing, 24, 576-579.
[Google Scholar] [CrossRef] [PubMed]
[11] Dumoulin, C. and Hay-Smith, J. (2010) Pelvic Floor Muscle Training versus No Treatment, or Inactive Control Treatments, for Urinary Incontinence in Women. Cochrane Database of Systematic Reviews, 1, CD005654.
[Google Scholar] [CrossRef
[12] Søren, H., Birgitte, M., Bodil, M., Christian, D.J. and Søren, R. (2009) Transcutaneous Electrical Nerve Stimulation for Refractory Daytime Urinary Urge Incontinence. The Journal of Urology, 182, 2072-2078.
[Google Scholar] [CrossRef] [PubMed]
[13] van der Lely, S., Liechti, M.D., Popp, W.L., Schmidhalter, M.R., Kessler, T.M. and Mehnert, U. (2019) Does Electrical Stimulation in the Lower Urinary Tract Increase Urine Production? A Randomised Comparative Proof-of-Concept Study in Healthy Volunteers. PLoS ONE, 14, e0217503.
[Google Scholar] [CrossRef] [PubMed]
[14] Fábio, Q., Luiza, V.M., Marília, M., Carolina, C., Fajardo, O.L., Patrícia, L., Murillo, B.N.J. and Ubirajara, B.J. (2015) Transcutaneous Parasacral Electrical Stimulation vs Oxybutynin for the Treatment of Overactive Bladder in Children: A Randomized Clinical Trial. The Journal of Urology, 193, 1749-1753.
[Google Scholar] [CrossRef] [PubMed]
[15] Yokozuka, M., Namima, T. and Nakagawa, H. (2004) Effects and Indications of Sacral Surface Therapeutic Electrical Stimulation in Refractory Urinary Incontinence. Clinical Rehabilitation, 18, 899-907.
[Google Scholar] [CrossRef] [PubMed]
[16] Martens, F.M., den Hollander, P.P., Snoek, G.J., Koldewijn, E.L., van Kerrebroeck, P.E. and Heesakkers, J.P. (2011) Quality of Life in Complete Spinal Cord Injury Patients with a Brindley Bladder Stimulator Compared to a Matched Control Group. Neurourology and Urodynamics, 30, 551-555.
[Google Scholar] [CrossRef] [PubMed]
[17] Kutzenberger, J., Domurath, B. and Sauerwein, D. (2005) Spastic Bladder and Spinal Cord Injury: Seventeen Years of Experience with Sacral Deafferentation and Implantation of an Anterior Root Stimulator. Artificial Organs, 29, 239-241.
[Google Scholar] [CrossRef] [PubMed]
[18] Boggs, J.W., Wenzel, B.J., Gustafson, K.J. and Grill, W.M. (2006) Bladder Emptying by Intermittent Electrical Stimulation of the Pudendal Nerve. Journal of Neural Engineering, 3, 43-51.
[Google Scholar] [CrossRef] [PubMed]
[19] Ju, Y.-H. and Liao, L.M. (2016) Electrical Stimulation of Dog Pudendal Nerve Regulates the Excitatory Pudendal-to-Bladder Reflex. Neural Regeneration Research, 11, 676-681.
[Google Scholar] [CrossRef] [PubMed]
[20] Allon, E.F. (2019) The Role of Neuromuscular Electrical Stimulation in the Rehabilitation of the Pelvic Floor Muscles. British Journal of Nursing, 28, 968-974.
[Google Scholar] [CrossRef] [PubMed]
[21] Herrmann, V., Potrick, B.A., Palma, P.C., Zanettini, C.L., Marques, A. and Netto, N.R. (2003) Júnior Eletroestimulação transvaginal do assoalho pélvico no tratamento da incontinência urinária de esforço: Avaliações clínica e ultra-sonográfica. Revista da Associação Médica Brasileira, 49, 401-405.
[Google Scholar] [CrossRef
[22] Joshua, Y.J., Shen, J.K., Pierce, M.A., Hardesty, J.S., Kim, J. and Sam, S. (2018) Intravesical Electrical Stimulation Treatment for Overactive Bladder: An Observational Study. Investigative and Clinical Urology, 59, 246-251.
[Google Scholar] [CrossRef] [PubMed]
[23] Laviana, A., Jellison, F. and Kim, J.-H. (2014) Sacral Neuromodulation for Refractory Overactive Bladder, Interstitial Cystitis, and Painful Bladder Syndrome. Neurosurgery Clinics of North America, 25, 33-46.
[Google Scholar] [CrossRef] [PubMed]
[24] Drake, M.J., Apostolidis, A., Cocci, A., et al. (2016) Neurogenic Lower Urinary Tract Dysfunction: Clinical Management Recommendations of the Neurologic Incontinence Committee of the Fifth International Consultation on Incontinence 2013. Neurourology and Urodynamics, 35, 657-665.
[Google Scholar] [CrossRef] [PubMed]
[25] Martin, B.P., Araneibia, F.M.I., Martinez, P.F.J., et al. (2003) Continuous Bilateral Sacral Neuromodulation as a Minimally Invasive Implantation Technique in Patients with Functional Bladder Changes. Archivos Españoles de Urología, 56, 497-450.
[26] Zhang, P., Wang, J.Y., et al. (2019) Results of Sacral Neuromodulation Therapy for Urinary Voiding Dysfunction: Five-Year Experience of a Retrospective, Multicenter Study in China. Neuromodulation, 22, 730-737.
[Google Scholar] [CrossRef] [PubMed]
[27] Sievert, K.-D., Amend, B., Gakis, G., Toomey, P., Badke, A., Kaps, H.P. and Stenzl, A. (2010) Early Sacral Neuromodulation Prevents Urinary Incontinence after Complete Spinal Cord Injury. Annals of Neurology, 67, 74-84.
[Google Scholar] [CrossRef] [PubMed]
[28] Fergany, L.A., Shaker, H., Arafa, M. and Elbadry, M.S. (2017) Does Sacral Pulsed Electromagnetic Field Therapy Have a Better Effect than Transcutaneous Electrical Nerve Stimulation in Patients with Neurogenic Overactive Bladder? Arab Journal of Urology, 15, 148-152.
[Google Scholar] [CrossRef] [PubMed]
[29] Bycroft, J.A., Craggs, M.D., Sheriff, M., Knight, S. and Shah, P.J.R. (2004) Does Magnetic Stimulation of Sacral Nerve Roots Cause Contraction or Suppression of the Bladder? Neurourology and Urodynamics, 23, 241-245.
[Google Scholar] [CrossRef] [PubMed]
[30] Yani, M.S., Wondolowski, J.H., Eckel, S.P., Kulig, K., Fisher, B.E., Gordon, J.E., et al. (2018) Distributed Representation of Pelvic Floor Muscles in Human Motor Cortex. Scientific Reports, 8, Article No. 7213.
[Google Scholar] [CrossRef] [PubMed]
[31] Niu, T.Y., Bennett, C.J., Keller, T.L., Leiter, J.C. and Lu, D.C. (2018) A Proof-of-Concept Study of Transcutaneous Magnetic Spinal Cord Stimulation for Neurogenic Bladder. Scientific Reports, 8, Article No. 12549.
[Google Scholar] [CrossRef] [PubMed]
[32] Lin, V.W., Hsiao, I. and Perkash, I. (1997) Micturition by Functional Magnetic Stimulation in Dogs: A Preliminary Report. Neurourology and Urodynamics, 16, 305-314.
[Google Scholar] [CrossRef
[33] Tsai, P.-Y., Wang, C.-P., Hsieh, C.-Y., Tsai, Y.-A., Yeh, S.-C. and Chuang, T.-Y. (2014) Long-Term Sacral Magnetic Stimulation for Refractory Stress Urinary Incontinence. Archives of Physical Medicine and Rehabilitation, 95, 231-238.
[Google Scholar] [CrossRef] [PubMed]
[34] Nunes, E.F.C., Sampaio, L.M.M., Biasotto-Gonzalez, D.A., Nagano, R.C.D.R., Lucareli, P.R.G. and Politti, F. (2018) Biofeedback for Pelvic Floor Muscle Training in Women with Stress Urinary Incontinence: A Systematic Review with Meta-Analysis. Physiotherapy, 105, 10-23.
[Google Scholar] [CrossRef] [PubMed]
[35] Fernández-Cuadros, M., Albaladejo-Florín, M., Álava-Rabasa, S. and Pérez-Moro, O. (2019) Effectiveness of 6 Manometric Biofeedback Sessions on Urinary Incontinence and Quality of Life: A Before-After Study of 67 Patients. Rehabilitacion, 53, 146-154.
[36] Dumoulin, C., Cacciari, L.P. and Hay-Smith, E.J.C. (2018) Pelvic Floor Muscle Training versus No Treatment, or Inactive Control Treatments, for Urinary Incontinence in Women. The Cochrane Database of Systematic Reviews, 10, CD005654.
[Google Scholar] [CrossRef
[37] 孙岚, 李建军, 王征美. 电针对脊髓损伤患者膀胱功能影响的尿动力学分析[J]. 中国康复理论与实践, 2005(11): 36-37.
[38] 杨涛, 刘志顺, 刘元石. 电针次、会阳穴治疗神经源性二便失禁30例[J]. 新中医, 2001, 33(12): 43.
[39] Karsenty, G., Denys, P., Amarenco, G., et al. (2008) Botulinum Toxin A(Botox) Intradetrusor Injections in Adults with Neurogenic Detrusor Overactivity/Neurogenic Overactive Bladder: A Systematic Literature Review. European Urology, 53, 275-287.
[Google Scholar] [CrossRef] [PubMed]
[40] Mehta, S.S. and Tophill, P.R. (2006) Memokath Stents for the Treatment of Detrusor Sphincter Dyssynergia (DSD) in Men with Spinal Cord Injury: The Princess Royal Spinal Injuries Unit 10-Year Experience. Spinal Cord, 44, 1-6.
[Google Scholar] [CrossRef] [PubMed]
[41] Gamé, X., Chartier-Kastler, E., Ayoub, N., et al. (2008) Outcome after Treatment of Detrusor-Sphincter Dyssynergia by Temporary Stent. Spinal Cord, 46, 74-77.
[Google Scholar] [CrossRef] [PubMed]
[42] Horstmann, M., Schaefer, T., Aguilar, Y., et al. (2006) Neurogenic Bladder Treatment by Doubling the Recommended Antimuscarinic Dosage. Neurourology and Urodynamics, 25, 441-445.
[Google Scholar] [CrossRef] [PubMed]
[43] Karsenty, G. and Reitz, A. (2006) Persistence of Therapeutic Effect after Repeated Injections of Botulinum Toxin Type A to Treat Incontinence Due to Neurogenic Detrusor Over-Activity. Urology, 68, 1193-1197.
[Google Scholar] [CrossRef] [PubMed]