含手性二芳基次甲基骨架化合物的合成研究
Studies on the Synthesis of Chiral Diarylmethine Skeleton Compounds
DOI: 10.12677/JOCR.2021.94009, PDF,    科研立项经费支持
作者: 夏艳萍, 欧阳露, 罗人仕：赣南医学院药学院，江西 赣州
关键词: 二芳基次甲基；不对称催化；药物合成；Diarylmethine； Asymmetric Catalysis； Drug Synthesis
摘要: 手性二芳基次甲基骨架是一类重要的结构单元，其广泛存在于药物分子及天然产物之中，在药物化学和临床治疗上有着极其重要的地位。近年来，利用不对称催化方法合成手性二芳基次甲基化合物受到了越来越多的合成化学家的关注，主要包括：1) 不对称共轭加成；2) 不对称Friedel-Crafts反应；3) 不对称烯丙基芳基化；4) 不对称氢化；5) 不对称偶联；6) 不对称的烯烃双官能团化等。本论文将根据反应类型的不同，对近年来含手性二芳基次甲基化合物的构建方法及其在天然产物及药物分子合成中的应用进行综述，对不同类型的合成方法有了一些规律性的认识，为将来含该类化合物骨架的药物分子合成提供理论指导和技术支持。
Abstract: Chiral diarylmethine skeleton is one of the most important structural units, which widely exists in drug molecules and natural products, and plays a crucial role in drug chemistry and clinical treatment. In recent years, the synthesis of chiral diarylmethine compounds by asymmetric catalysis has attracted more and more attention of synthetic chemists, including: 1) asymmetric conjugate addition; 2) asymmetric Friedel-Crafts reaction; 3) asymmetric allyl arylation; 4) asymmetric hydrogenation; 5) asymmetric coupling; 6) asymmetric difunctionalization of alkenes, etc. This paper summarizes the latest research on this asymmetric catalysis, containing the construction of chiral diarymethine and the application in the synthesis of natural product and drug molecules, which will give some recognition for different types of synthetic methods and provide theoretical guidance and technical support for the synthesis of drug molecules which contains the skeleton of diarymethine.
文章引用：夏艳萍, 欧阳露, 罗人仕. 含手性二芳基次甲基骨架化合物的合成研究[J]. 有机化学研究, 2021, 9(4): 68-82. https://doi.org/10.12677/JOCR.2021.94009

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