米曲菌胰酶片联合马来酸曲美布汀片治疗老年人功能性消化不良的疗效观察

Observation on the Therapeutic Effect of Oryz-Aspergillus Enzyme and Pancreatin Tablets Combined with Trimebutine Maleate Tablets on Functional Dyspepsia in the Elderly

摘要: 目的：研究米曲菌胰酶片联合马来酸曲美布汀片对老年患者功能性消化不良的治疗效果。方法：选取2019年12月~2021年10月青岛大学附属医院接诊的78例老年功能性消化不良患者为研究对象，采用随机数字表法分为对照组和观察组，每组39例，比较两组治疗30 d后阿雷格里港消化不良问卷及SF-36生活质量问卷测评结果。结果：观察组治疗后PADYQ症状评分均低于对照组，差异有统计学意义(P < 0.05)；观察组治疗后SF-36评分在BP、MH、SF、GH四个维度高于对照组，差异有统计学意义(P < 0.05)；观察组治疗总有效率为87.2%，高于对照组的64.1%，差异有统计学意义(P < 0.05)；观察组临床不良反应发生率为2.56%，与对照组的5.13%比较，差异无统计学意义(P > 0.05)。结论：米曲菌胰酶片联合马来酸曲美布汀片治疗老年人功能性消化不良的临床效果显著，且不会增加不良反应，安全性高，值得在临床推广。

Abstract: Objective: To study the therapeutic effect of Oryz-Aspergillus Enzyme and Pancreatin Tablets combined with Trimebutine Maleate Tablets on functional dyspepsia in the elderly patients. Methods: Seventy-eight elderly patients with functional dyspepsia admitted to the Affiliated Hospital of Qingdao University from December 2019 to October 2021 were selected as the study subjects and divided into the control group and the observation group by random number table, 39 cases in each group. The results of PADYQ Dyspepsia Questionnaire and SF-36 quality of life questionnaire after 30 days of treatment were compared between the two groups. Results: After treatment, the PADYQ score in the observation group was lower than that in the control group, and the difference had statistical significance (P < 0.05); after treatment, the SF-36 score in the four dimensions of BP, MH, SF and GH in the observation group was higher than that in the control group, and the difference had statistical significance (P < 0.05); the overall response rate in the observation group was 87.2%, higher than 64.1% in the control group, and the difference had statistical significance (P < 0.05); the incidence rate of clinical adverse reactions in the observation group was 2.56%, compared with 5.13% in the control group, the difference had no statistical significance (P > 0.05). Conclusion: Oryz-Aspergillus Enzyme and Pancreatin Tablets combined with Trimebutine Maleate Tablets in the treatment of elderly patients with functional dyspepsia has a significant clinical effect, with unincreasing adverse reactions and high safety. It is worthy of clinical promotion.