中药抑制金黄色葡萄球菌的研究进展
Research Progress of Traditional Chinese Medicine Inhibiting Staphylococcus aureus
摘要: 金黄色葡萄球菌(Staphylococcus aureus, SA)是广泛存在于自然界中的一种致病菌，人体一旦被感染，轻者可能会引起食物中毒，肺炎等疾病，严重则会引起败血症，感染性心内膜炎等危及性命的疾病。金黄色葡萄球菌的防治以及消除也逐渐受到广泛重视。一直以来，抗生素因为其用量少便可发挥巨大功效作为主要治疗手段，但长期使用导致不断有耐药菌株产生，甚至出现了多重耐药性，因此寻找新的治疗细菌感染的途径迫在眉睫，成为我们目前不可忽视的挑战。近些年来，我国传统治疗方法——中医药逐渐受到越来越多的关注，不断有研究表明中药不仅有消炎，抗肿瘤的作用，部分中药更是表现出显著的抑菌杀菌效果。因此根据近年来已有研究成果的中药进行切实实验，运用多种实验方法研究中药抑制金黄色葡萄球菌耐药性产生的机制，探明抑制金黄色葡萄球菌生长繁殖的原理，不断开发我国中医药的宝库，进而找出具有抑菌效果的中药，通过比较找出效果更好的中药，在一定程度上为临床寻找新型抗菌药物提供指导。
Abstract: Staphylococcus aureus (SA) is a pathogenic bacterium that exists widely in nature. Once the human body is infected, it may cause food poisoning, pneumonia and other diseases in mild cases, and infectious sepsis and endocarditis and other life-threatening diseases in severe cases. The prevention and elimination of Staphylococcus aureus has gradually received widespread attention. For a long time, antibiotics can exert great efficacy as the main treatment method because of their small dosage. However, long-term use has led to the emergence of drug-resistant strains and even multi-drug resistance. Therefore, it is urgent to find new ways to treat bacterial infections. We cannot ignore the challenges at present. In recent years, my country’s traditional treatment method— traditional Chinese medicine—has gradually received more and more attention. Constant research has shown that traditional Chinese medicine not only has anti-inflammatory and anti-tumor effects, but some Chinese medicines have shown significant antibacterial and bactericidal effects. Therefore, we have carried out practical experiments based on the Chinese medicines that have been researched in recent years, used a variety of experimental methods to study the mechanism of Chinese medicines inhibiting the development of Staphylococcus aureus resistance, ascertained the principle of inhibiting the growth and reproduction of Staphylococcus aureus, and continued to develop Chinese traditional medicines. To find out the Chinese medicine with antibacterial effect, and find out the Chinese medicine with better effect through comparison, to a certain extent, provide guidance for the clinical search for new antibacterial drugs.
文章引用：杨婷, 董晨旭, 姚晓栋, 李宏宇, 院霞, 邢丽娟, 王文娟, 潘海婷. 中药抑制金黄色葡萄球菌的研究进展[J]. 临床医学进展, 2022, 12(4): 3153-3161. https://doi.org/10.12677/ACM.2022.124455

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