[1]
|
Jeha, S., et al. (2019) Improved CNS Control of Childhood Acute Lymphoblastic Leukemia without Cranial Irradiation: St Jude Total Therapy Study 16. Journal of Clinical Oncology, 37, 3377-3391.
https://doi.org/10.1200/JCO.19.01692
|
[2]
|
van der Velden, V.H.J., de Launaij, D., de Vries, J.F., de Haas, V., Sonneveld, E., Voerman, J.S.A., et al. (2016) New Cellular Markers at Diagnosis Are Associated with Isolated Central Nervous System Relapse in Paediatric B-Cell Precursor Acute Lymphoblastic Leukaemia. British Journal of Haematolo-gy, 172, 769-781.
https://doi.org/10.1111/bjh.13887
|
[3]
|
Tang, J., Yu, J., Cai, J., Zhang, L., Hu, S., Gao, J., et al. (2021) Prognostic Factors for CNS Control in Children with Acute Lymphoblastic Leukemia Treated without Cranial Irradiation. Blood, 138, 331-343.
https://doi.org/10.1182/blood.2020010438
|
[4]
|
徐康康, 廖清船, 张永, 等. MTHFR C677T和RFC1 G80A基因多态性对急性淋巴细胞白血病患儿大剂量甲氨蝶呤化疗不良反应的影响[J]. 实用儿科临床杂志, 2009, 24(21): 1674-1676, 1696.
|
[5]
|
Lopez-Lopez, E., Martin-Guerrero, I., Ballesteros, J. and Garcia-Orad, A. (2013) A Systematic Review and Meta- Analysis of MTHFR Polymorphisms in Methotrexate Toxicity Prediction in Pediatric Acute Lympho-blastic Leukemia. The Pharmacogenomics Journal, 13, 498-506. https://doi.org/10.1038/tpj.2012.44
|
[6]
|
Koppen, I.J.N., Hermans, F.J.R. and Kaspers, G.J.L. (2010) Folate Related Gene Polymorphisms and Susceptibility to Develop Childhood Acute Lymphoblastic Leukaemia. British Journal of Haematology, 148, 3-14.
https://doi.org/10.1111/j.1365-2141.2009.07898.x
|
[7]
|
Esmaili, M.A., Kazemi, A., Faranoush, M., Mellstedt, H., Zaker, F., Safa, M., et al. (2020) Polymorphisms within Methotrexate Pathway Genes: Relationship between Plasma Methotrexate Levels, Toxicity Experienced and Outcome in Pediatric Acute Lymphoblastic Leukemia. Iranian Journal of Basic Medical Sciences, 23, 800-809.
|
[8]
|
郑明霞, 赵文理. MTHFR基因多态性与急性淋巴细胞白血病患儿甲氨蝶呤化疗后不良反应及临床预后的关系[J]. 山东医药, 2020, 60(4): 26-29. https://doi.org/10.3969/j.issn.1002-266X.2020.04.007
|
[9]
|
裴保方, 陶兴茹, 刘炜, 等. MTHFR基因多态性对大剂量甲氨蝶呤化疗后患儿血药浓度及药物不良反应的影响[J]. 中国合理用药探索, 2021, 18(10): 36-40. https://doi.org/10.3969/j.issn.2096-3327.2021.10.009
|
[10]
|
白小红, 牛佳慧, 倪美艳, 童荣生. MTHFR基因多态性与大剂量甲氨蝶呤治疗儿童急性淋巴细胞白血病的临床疗效及药物不良反应的相关性分析[J]. 中国临床药理学杂志, 2021, 37(22): 3056-3059.
https://doi.org/10.13699/j.cnki.1001-6821.2021.22.010
|
[11]
|
陈洋, 夏江宝, 何晓东, 沈佐君. MTHFR基因多态性在MTX治疗急性淋巴细胞白血病过程中毒性反应的Meta分析[J]. 中华疾病控制杂志, 2015, 19(8): 811-815. https://doi.org/10.16462/j.cnki.zhjbkz.2015.08.014
|
[12]
|
de Jonge, R., Hooijberg, J.H., van Zelst, B.D., Jansen, G., van Zantwijk, C.H., Kaspers, G.J., et al. (2005) Effect of Polymorphisms in Folate-Related Genes on in Vitro Metho-trexate Sensitivity in Pediatric Acute Lymphoblastic Leukemia. Blood, 106, 717-720. https://doi.org/10.1182/blood-2004-12-4941
|
[13]
|
Zhu, C., Liu, Y.W., Wang, S.Z., et al. (2018) Associations be-tween the C677T and A1298C Polymorphisms of MTHFR and the Toxicity of Methotrexate in Childhood Malignancies: A Meta-Analysis. The Pharmacogenomics Journal, 18, 450-459. https://doi.org/10.1038/tpj.2017.34
|
[14]
|
Suthandiram, S., Gan, G.-G., Zain, S.M., et al. (2014) Effect of Polymor-phisms within Methotrexate Pathway Genes on Methotrexate Toxicity and Plasma Levels in Adults with Hematological Malignancies. Pharmacogenomics, 15, 1479- 1494. https://doi.org/10.2217/pgs.14.97
|
[15]
|
Patiño-García, A., Zalacaín, M., Marrodán, L., San-Julián, M. and Sierrasesúmaga, L. (2009) Methotrexate in Pediatric Osteosarcoma: Re-sponse and Toxicity in Relation to Genetic Polymorphisms and Dihydrofolate Reductase and Reduced Folate Carrier 1 Expression. The Journal of Pediatrics, 154, 688-693.
https://doi.org/10.1016/j.jpeds.2008.11.030
|
[16]
|
D’Angelo, V., Ramaglia, M., Iannotta, A., et al. (2011) Metho-trexate Toxicity and Efficacy During the Consolidation Phase in Paediatric Acute Lymphoblastic Leukaemia and MTHFR Polymorphisms as Pharmacogenetic Determinants. Cancer Chemotherapy and Pharmacology, 68, 1339-1346. https://doi.org/10.1007/s00280-011-1665-1
|
[17]
|
杨丽华, 刘茹, 曾其毅. 急性淋巴细胞白血病患儿亚甲基四氢叶酸还原酶基因多态性与大剂量甲氨蝶呤不良反应的相关性[J]. 实用儿科临床杂志, 2012, 27(6): 440-442. https://doi.org/10.3969/j.issn.1003-515X.2012.06.015
|
[18]
|
聂朝霞, 刘岚, 崔巍. MTHRF基因C677T多态性与ALL患儿MTX血药浓度和毒副反应的相关性[J]. 医学临床研究, 2012, 29(2): 295-298. https://doi.org/10.3969/j.issn.1671-7171.2012.02.037
|
[19]
|
Ongaro, A., De Mattei, M., Della Porta, M.G., et al. (2009) Gene Polymorphisms in Folate Metabolizing Enzymes in Adult Acute Lymphoblastic Leukemia: Effects on Methotrexate-Related Toxicity and Survival. Haematologica, 94, 1391- 1398. https://doi.org/10.3324/haematol.2009.008326
|
[20]
|
陈开杰, 戴成家, 房光萃, 费燕. 亚甲基四氢叶酸还原酶基因多态性与甲氨蝶呤治疗儿童急性淋巴细胞白血病毒副反应关系的荟萃分析[J]. 药学服务与研究, 2018, 18(5): 337-342. https://doi.org/10.5428/pcar20180506
|
[21]
|
史天陆, 张永煌, 李宇, 等. 亚甲基四氢叶酸还原酶基因C677T和A1298C多态性与甲氨蝶呤致血液系统不良反应关系的Meta分析[J]. 药物不良反应杂志, 2016, 18(5): 321-329.
https://doi.org/10.3760/cma.j.issn.1008-5734.2016.05.001
|
[22]
|
Ojha, R.P. and Gurney, J.G. (2014) Methylenetet-rahydrofolate Reductase C677T and Overall Survival in Pediatric Acute Lymphoblastic Leukemia: A Systematic Review. Leukemia & Lymphoma, 55, 67-73.
https://doi.org/10.3109/10428194.2013.792336
|
[23]
|
张春燕, 任晓蕾, 冯婉玉. 大剂量甲氨蝶呤致急性肾损伤及消除延迟的药物相关基因多态性分析[J]. 医药导报, 2018, 37(10): 1275-1277. https://doi.org/10.3870/j.issn.1004-0781.2018.10.030
|
[24]
|
Kimchi-Sarfaty, C., Oh, J.M., Kim, I.W., Sauna, Z.E., Calcagno, A.M., Ambudkar, S.V., et al. (2007) A “Silent” Polymorphism in the MDR1 Gene Changes Substrate Speci-ficity. Science, 315, 525-528.
https://doi.org/10.1126/science.1135308
|
[25]
|
张春燕, 任晓蕾, 冯婉玉, 等. MTHFR和ABCB1基因多态性对大剂量甲氨蝶呤毒性反应及排泄延迟的影响[J]. 中国新药杂志, 2019, 28(1): 117-120.
|
[26]
|
Ramirez-Pacheco, A., Moreno-Guerrero, S., Alamillo, I., et al. (2016) Mexican Childhood Acute Lymphoblastic Leukemia: A Pilot Study of the MDR1 and MTHFR Gene Polymorphisms and Their Associations with Clinical Outcomes. Genetic Testing and Mo-lecular Biomarkers, 20, 597-602. https://doi.org/10.1089/gtmb.2015.0287
|
[27]
|
刘爽, 宋再伟, 易湛苗, 赵荣生. 血液肿瘤患者中多药耐药基因多态性对大剂量甲氨蝶呤不良事件影响的分析[J]. 中国临床药理学杂志, 2019, 35(19): 2421-2425. https://doi.org/10.13699/j.cnki.1001-6821.2019.19.060
|
[28]
|
Zgheib, N.K., Akra-Ismail, M., Aridi, C., et al. (2014) Genetic Polymorphisms in Candidate Genes Predict Increased Toxicity with Methotrexate Therapy in Lebanese Children with Acute Lymphoblastic Leukemia. Pharmacogenetics and Genomics, 24, 387-396. https://doi.org/10.1097/FPC.0000000000000069
|
[29]
|
马乐, 吕冬梅, 韩佳. 血液肿瘤患儿MTHFR和ABCB1基因多态性与甲氨蝶呤骨髓抑制的相关性[J]. 实用药物与临床, 2022, 25(1): 32-36. https://doi.org/10.14053/j.cnki.ppcr.202201004
|
[30]
|
Gregers, J., Gréen, H., Christensen, I.J., Dalhoff, K., Schroeder, H., Carlsen, N., et al. (2015) Polymorphisms in the ABCB1 Gene and Effect on Outcome and Toxicity in Childhood Acute Lymphoblastic Leukemia. The Pharmacogenomics Journal, 15, 372-379. https://doi.org/10.1038/tpj.2014.81
|
[31]
|
Rao, D.N., Anuradha, C., Vishnupriya, S., Sailaja, K., Surekha, D., Raghunadharao, D. and Rajappa, S. (2010) Association of an MDR1 Gene (C3435T) Polymorphism with Acute Leuke-mia in India. Asian Pacific Journal of Cancer Prevention, 11, 1063-1066.
|
[32]
|
Pikman, Y., Ocasio-Martinez, N., Alexe, G., et al. (2022) Targeting Serine Hydroxymethyltransferases 1 and 2 for T-Cell Acute Lymphoblastic Leukemia Thera-py. Leukemia, 36, 348-360. https://doi.org/10.1038/s41375-021-01361-8
|
[33]
|
Vijayakrishnan, J. and Houlston, R.S. (2010) Candidate Gene Association Studies and Risk of Childhood Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis. Haematologica, 95, 1405-1414.
https://doi.org/10.3324/haematol.2010.022095
|
[34]
|
Skibola, C.F., Smith, M.T., Hubbard, A., et al. (2002) Poly-morphisms in the Thymidylate Synthase and Serine Hydroxymethyltransferase Genes and Risk of Adult Acute Lym-phocytic Leukemia. Blood, 99, 3786-3791.
https://doi.org/10.1182/blood.V99.10.3786
|
[35]
|
Bahari, G., Hashemi, M., Naderi, M., Sadeghi-Bojd, S. and Taheri, M. (2016) Association of SHMT1 Gene Polymorphisms with the Risk of Childhood Acute Lymphoblastic Leu-kemia in a Sample of Iranian Population. Cellular and Molecular Biology, 62, 45-51.
|
[36]
|
丁慧, 岳丽杰, 于洁, 等. 丝氨酸羟甲基转移酶1基因C1420T位点和3’-非翻译区3个位点单核苷酸多态性与儿童急性白血病易感性的关系[J]. 临床检验杂志, 2013, 31(10): 778-781.
|
[37]
|
丁慧, 岳丽杰, 于洁, 等. SHMT1多态性与ALL儿童HD-MTX不良反应的关系[J]. 中国肿瘤临床, 2014(3): 162-165. https://doi.org/10.3969/j.issn.1000-8179.20131420
|
[38]
|
Kotnik, B.F., Dolžan, V., Grabnar, I. and Jazbec, J. (2010) Relationship of the Reduced Folate Carrier Gene Polymorphism G80A to Methotrexate Plasma Concentration, Toxicity, and Disease Outcome in Childhood Acute Lymphoblastic Leukemia. Leukemia & Lymphoma, 51, 724-726. https://doi.org/10.3109/10428191003611402
|
[39]
|
Dervieux, T., Kremer, J., Lein, D.O, et al. (2004) Contribution of Common Polymorphisms in Reduced Folate Carrier and γ-Glutamylhydrolase to Methotrexate Polyglutamate Levels in Patients with Rheumatoid Arthritis. Pharmacogenetics, 14, 733-739. https://doi.org/10.1097/00008571-200411000-00004
|
[40]
|
Imanishi, H., Okamura, N., Yagi, M., et al. (2007) Ge-netic Polymorphisms Associated with Adverse Events and Elimination of Methotrexate in Childhood Acute Lympho-blastic Leukemia and Malignant Lymphoma. Journal of Human Genetics, 52, 166-171. https://doi.org/10.1007/s10038-006-0096-z
|
[41]
|
Leyva-Vázquez, M.A., Organista-Nava, J., Gómez-Gómez, Y., et al. (2012) Polymorphism G80A in the Reduced Folate Carrier Gene and its Relationship to Survival and Risk of Relapse in Acute Lymphoblastic Leukemia. Journal of Investigative Medicine, 60, 1064-1067. https://doi.org/10.2310/JIM.0b013e31826803c1
|
[42]
|
顾平, 刘易陇, 何霞, 童荣生. 还原叶酸载体基因多态性与大剂量甲氨蝶呤药物不良反应关系的Meta分析[J]. 中国临床药理学杂志, 2016, 32(15): 1432-1434. https://doi.org/10.13699/j.cnki.1001-6821.2016.15.026
|
[43]
|
李红, 蒋慧, 刘青. RFC1基因多态性与大剂量甲氨蝶呤治疗反应的相关性[J]. 上海交通大学学报(医学版), 2014, 34(9):1376-1380. https://doi.org/10.3969/j.issn.1674-8115.2014.09.023
|
[44]
|
杨丽华, 余晶, 邓兰, 等. 急性淋巴细胞白血病患儿还原叶酸载体基因多态性与甲氨蝶呤不良反应的关系[J]. 临床儿科杂志, 2011, 29(5): 425-428. https://doi.org/10.3969/j.issn.1000-3606.2011.05.007
|
[45]
|
张春燕, 黄琳, 任晓蕾, 封宇飞. 还原性叶酸载体1 G80A基因多态性与急性淋巴细胞白血病患儿使用大剂量甲氨蝶呤不良反应关系的系统评价[J]. 中国医院用药评价与分析, 2021, 21(2): 204-206.
https://doi.org/10.14009/j.issn.1672-2124.2021.02.019
|
[46]
|
Laverdière, C., Chiasson, S., Costea, I., Moghrabi, A. and Krajinovic, M. (2002) Polymorphism G80A in the Reduced Folate Carrier Gene and Its Relationship to Methotrexate Plasma Levels and Outcome of Childhood Acute Lymphoblastic Leukemia. Blood, 100, 3832-3834. https://doi.org/10.1182/blood.V100.10.3832
|
[47]
|
Gregers, J., Christensen, I.J., Dalhoff, K., et al. (2010) The As-sociation of Reduced Folate Carrier 80G>A Polymorphism to Outcome in Childhood Acute Lymphoblastic Leukemia Interacts with Chromosome 21 Copy Number. Blood, 115, 4671-4677. https://doi.org/10.1182/blood-2010-01-256958
|
[48]
|
高萍, 张华年. SLCO1 B1基因多态性对甲氨蝶呤治疗的影响[J]. 中国临床药理学杂志, 2014(8): 730-732.
|
[49]
|
Treviño, L.R., Shimasaki, N., Yang, W., Panetta, J.C., Cheng, C., Pei, D., et al. (2009) Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated with Methotrexate Pharmacokinetics and Clinical Effects. Journal of Clinical Oncology, 27, 5972-5978. https://doi.org/10.1200/JCO.2008.20.4156
|
[50]
|
Ramsey, L.B., Bruun, G.H., Yang, W., Trevino, L.R., Vattathil, S., Scheet, P., et al. (2012) Rare versus Common Variants in Pharmacogenetics: SLCO1B1 Variation and Methotrexate Disposition. Genome Research, 22, 1-8.
https://doi.org/10.1101/gr.129668.111
|
[51]
|
Ramsey, L.B., Panetta, J.C., Smith, C., Yang, W., Fan, Y., Winick, N.J., et al. (2013) Genome-Wide Study of Methotrexate Clearance Replicates SLCO1B1. Blood, 121, 898-904. https://doi.org/10.1182/blood-2012-08-452839
|
[52]
|
Liu, S.-G., Gao, C., Zhang, R.-D., et al. (2017) Polymor-phisms in Methotrexate Transporters and Their Relationship to Plasma Methotrexate Levels, Toxicity of High-Dose Methotrexate, and Outcome of Pediatric Acute Lymphoblastic Leukemia. Oncotarget, 8, 37761-37772. https://doi.org/10.18632/oncotarget.17781
|
[53]
|
Tirona, R.G., Leake, B.F., Merino, G. and Kim, R.B. (2001) Poly-morphisms in OATP-C: Identification of Multiple Allelic Variants Associated with Altered Transport Activity Among European- and African-Americans. The Journal of Biological Chemistry, 276, 35669-35675. https://doi.org/10.1074/jbc.M103792200
|
[54]
|
Chiusolo, P., Giammarco, S., Bellesi, S., et al. (2012) The Role of MTHFR and RFC1 Polymorphisms on Toxicity and Outcome of Adult Patients with Hematological Malignancies Treat-ed with High-Dose Methotrexate Followed by Leucovorin Rescue. Cancer Chemotherapy and Pharmacology, 69, 691-696.
https://doi.org/10.1007/s00280-011-1751-4
|
[55]
|
杨帆, 许刚. 骨肉瘤患者SLCO1B1基因多态性与大剂量甲氨蝶呤不良反应的相关性[J]. 中国临床药学杂志, 2019, 28(4): 250-253. https://doi.org/10.19577/j.1007-4406.2019.04.003
|
[56]
|
Lopez-Lopez, E., Martin-Guerrero, I., Ballesteros, J., Pi-ñan, M.A., Garcia-Miguel, P., Navajas, A. and Garcia-Orad, A. (2011) Polymorphisms of the SLCO1B1 Gene Predict Methotrexate-Related Toxicity in Childhood Acute Lymphoblastic Leukemia. Pediatric Blood & Cancer, 57, 612-619. https://doi.org/10.1002/pbc.23074
|