丙型肝炎病毒基因分型的相关研究进展
Related Research Progress in Genotyping of Hepatitis C Virus
DOI: 10.12677/ACM.2023.1351061, PDF,  被引量   
作者: 李娜娜:青海大学研究生院,青海 西宁;张永栋*:青海大学附属医院医院感染管理科,青海 西宁
关键词: 丙型肝炎病毒基因分型基因型检测临床意义Hepatitis C Virus Genotyping Genotype Detection Clinical Significance
摘要: 丙型病毒性肝炎(丙肝)是常见的慢性传染病之一,是造成全球重大健康和经济负担的原因。丙型肝炎病毒基因分型是疾病严重程度和发病机制以及患者对抗病毒治疗反应的重要决定因素,基因分型的研究对了解丙肝流行病学特征、制定抗病毒治疗的个体化方案均有重要的临床参考价值,将有助于更好地为丙肝防治管理策略提供信息。
Abstract: Viral hepatitis C (HCV) is one of the most common chronic infectious diseases and is the cause of a significant global health and economic burden. Hepatitis C virus genotyping is an important deter-minant of disease severity and pathogenesis as well as the response of patients to antiviral therapy. The study of genotyping has important clinical reference value for understanding the epidemiolog-ical characteristics of hepatitis C and developing individualized antiviral therapy programs, and will help to provide better information for the prevention and treatment management strategies of hepatitis C.
文章引用:李娜娜, 张永栋. 丙型肝炎病毒基因分型的相关研究进展[J]. 临床医学进展, 2023, 13(5): 7598-7603. https://doi.org/10.12677/ACM.2023.1351061

参考文献

[1] Petruzziello, A., Marigliano, S., Loquercio, G., Cozzolino, A. and Cacciapuoti, C. (2016) Global Epidemiology of Hepa-titis C Virus Infection: An Up-Date of the Distribution and Circulation of Hepatitis C Virus Genotypes. World Journal of Gastroenterology, 22, 7824-7840. [Google Scholar] [CrossRef] [PubMed]
[2] Smith, D.B., Bukh, J., Kuiken, C., Muerhoff, A.S., Rice, C.M., Stapleton, J.T. and Simmonds, P. (2014) Expanded Classification of Hepatitis C Virus into 7 Genotypes and 67 Subtypes: Updated Criteria and Genotype Assignment Web Resource. Hepatology, 59, 318-327. [Google Scholar] [CrossRef] [PubMed]
[3] Morozov, V.A. and Lagaye, S. (2018) Hepatitis C Virus: Morphogenesis, Infection and Therapy. World Journal of Hepatology, 10, 186-212. [Google Scholar] [CrossRef] [PubMed]
[4] 张莉娟, 刘炳华, 马翠华. 《2018年世界卫生组织慢性HCV感染的管理和治疗指南》摘译[J]. 临床肝胆病杂志, 2018, 34(10): 2121-2123.
[5] Coppola, N., Alessio, L., Onorato, L., Sagnelli, C., Macera, M., Sagnelli, E. and Pisa-turo, M. (2019) Epidemiology and Management of Hepatitis C Virus Infections in Immigrant Populations. Infectious Diseases of Poverty, 8, Article No. 17. [Google Scholar] [CrossRef] [PubMed]
[6] American Association for the Study of Liver Diseases and the Infectious Diseases Society of America (n.d.) HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C.
https://www.hcvguidelines.org/
[7] Saeed, Y.A., Phoon, A., Bie-lecki, J.M., Mitsakakis, N., Bremner, K.E., Abrahamyan, L., Pechlivanoglou, P., Feld, J.J., Krahn, M. and Wong, W.W.L. (2020) A Systematic Review and Meta-Analysis of Health Utilities in Patients with Chronic Hepatitis C. Value in Health, 23, 127-137. [Google Scholar] [CrossRef] [PubMed]
[8] Roudot-Thoraval, F. (2021) Epidemiology of Hepatitis C Virus Infection. Clinics and Research in Hepatology and Gastroenterology, 45, Article ID: 101596. [Google Scholar] [CrossRef] [PubMed]
[9] Carrat, F., Fontaine, H., Dorival, C., Simony, M., Diallo, A., Hezode, C., De Ledinghen, V., Larrey, D., Haour, G., Bronowicki, J.P., Zoulim, F., Asselah, T., Marcellin, P., Thabut, D., Leroy, V., Tran, A., Habersetzer, F., Samuel, D., Guyader, D., Chazouilleres, O., et al. (2019) Clinical Outcomes in Patients with Chronic Hepatitis C after Direct-Acting Antiviral Treatment: A Prospective Cohort Study. Lancet, 393, 1453-1464. [Google Scholar] [CrossRef
[10] Belli, L.S., Perricone, G., Adam, R., Cortesi, P.A., Strazza-bosco, M., Facchetti, R., Karam, V., Salizzoni, M., Andujar, R.L., Fondevila, C., De Simone, P., Morelli, C., Fa-bregat-Prous, J., Samuel, D., Agarwaal, K., Moreno Gonzales, E., Charco, R., Zieniewicz, K., De Carlis, L., Duvoux, C., et al. (2018) Impact of DAAs on Liver Transplantation: Major Effects on the Evolution of Indications and Results. An ELITA Study Based on the ELTR Registry. Journal of Hepatology, 69, 810-817. [Google Scholar] [CrossRef] [PubMed]
[11] Messina, J.P., Humphreys, I., Flaxman, A., Brown, A., Cooke, G.S., Pybus, O.G. and Barnes, E. (2015) Global Distribution and Prevalence of Hepatitis C Virus Genotypes. Hepatolo-gy, 61, 77-87. [Google Scholar] [CrossRef] [PubMed]
[12] Polaris Observatory HCV Collaborators (2017) Global Prevalence and Genotype Distribution of Hepatitis C Virus Infection in 2015: A Modelling Study. The Lancet Gastroen-terology and Hepatology, 2, 161-176. [Google Scholar] [CrossRef
[13] Zhang, Y., Chen, L.-M. and He, M. (2017) Hepatitis C Virus in Mainland China with an Emphasis on Genotype and Subtype Distribution. Virology Journal, 14, Article No. 41. [Google Scholar] [CrossRef] [PubMed]
[14] Rao, H., Wei, L., Lopez-Talavera, J.C., Shang, J., Chen, H., Li, J., Xie, Q., Gao, Z., Wang, L., Wei, J., Jiang, J., Sun, Y., Yang, R., Li, H., Zhang, H., Gong, Z., Zhang, L., Zhao, L., Dou, X., Niu, J., et al. (2014) Distribution and Clinical Correlates of Viral and Host Genotypes in Chinese Patients with Chronic Hepatitis C Virus Infection. Journal of Gastroenterology and Hepatology, 29, 545-553. [Google Scholar] [CrossRef] [PubMed]
[15] 中华医学会肝病学分会, 中华医学会感染病学分会. 丙型肝炎防治指南(2022年版) [J]. 中华肝脏病杂志, 2022, 30(12): 1332-1348.
[16] Halfon, P., Trimoulet, P., Bourliere, M., Khiri, H., de Lédinghen, V., Couzigou, P., Feryn, J.M., Alcaraz, P., Renou, C., Fleury, H.J. and Ouzan, D. (2001) Hepatitis C Vi-rus Genotyping Based on 5’ Noncoding Sequence Analysis (Trugene). Journal of Clinical Microbiology, 39, 1771-1773. [Google Scholar] [CrossRef
[17] Antonishyn, N.A., Ast, V.M., McDonald, R.R., Chaudhary, R.K., Lin, L., Andonov, A.P. and Horsman, G.B. (2005) Rapid Genotyping of Hepatitis C Virus by Pri-mer-Specific Extension Analysis. Journal of Clinical Microbiology, 43, 5158-5163. [Google Scholar] [CrossRef
[18] Verbeeck, J., Stanley, M.J., Shieh, J., Celis, L., Huyck, E., Wollants, E., Morimoto, J., Farrior, A., Sablon, E., Jankowski-Hennig, M., Schaper, C., Johnson, P., Van Ranst, M. and Van Brussel, M. (2008) Evaluation of Versant Hepatitis C Virus Genotype Assay (LiPA) 2.0. Journal of Clinical Microbiology, 46, 1901-1906. [Google Scholar] [CrossRef
[19] Yukimasa, N., Yoshida, K., Ohkushi, H., Tanabe, S., Fukasawa, K., Kanou, M., Fukuchi, K., Takagi, Y. and Gomi, K. (2001) Rinshobyori. The Japanese Journal of Clinical Pathology, 49, 711-715.
[20] 周一萌, 窦晓光, 张琳. 丙型肝炎病毒基因分型检测方法研究进展[J]. 中国实用内科杂志, 2014, 34(8): 819-822.
[21] Lindh, M. and Hannoun, C. (2005) Genotyping of Hepatitis C Virus by Taqman Real-Time PCR. Journal of Clinical Virology, 34, 108-114. [Google Scholar] [CrossRef] [PubMed]
[22] Lee, M.-H., Yang, H.-I., Lu, S.-N., Jen, C.-L., You, S.-L., Wang, L.-Y., L'Italien, G., Chen, C.-J. and Yuan, Y. (2014) Hepatitis C Virus Geno-type 1b Increases Cumulative Lifetime Risk of hepaTocellular Carcinoma. International Journal of Cancer, 135, 1119-1126. [Google Scholar] [CrossRef] [PubMed]
[23] Ampuero, J., Romero-Gómez, M. and Reddy, K.R. (2014) Re-view Article: HCV Genotype 3—The New Treatment Challenge. Alimentary Pharmacology & Therapeutics, 39, 686-698. [Google Scholar] [CrossRef] [PubMed]
[24] Aytug, S., Reich, D., Sapiro, L.E., Bernstein, D. and Begum, N. (2003) Impaired IRS-1/PI3-Kinase Signaling in Patients with HCV: A Mechanism for Increased Prevalence of Type 2 Diabetes. Hepatology, 38, 1384-1392. [Google Scholar] [CrossRef] [PubMed]
[25] Shi, S.T., Polyak, S.J., Tu, H., Taylor, D.R., Gretch, D.R. and Lai, M.M. (2002) Hepatitis C Virus NS5A Colocalizes with the Core Protein on Lipid Droplets and Interacts with Apolipo-proteins. Virology, 292, 198-210. [Google Scholar] [CrossRef] [PubMed]
[26] Yang, J., Liu, H.-X., Su, Y.-Y., Liang, Z.-S. and Rao, H.-Y. (2022) Distribution and Changes in Hepatitis C Virus Genotype in China from 2010 to 2020. World Journal of Clinical Cases, 10, 4480-4493. [Google Scholar] [CrossRef] [PubMed]
[27] 杨慧洁, 虞莉莎, 殷雪瑞, 等. CHC患者HCV基因分型及与肝功能指标的关系[J]. 医学研究杂志, 2020, 9(5): 93-96, 75.
[28] Peta, V., Torti, C., Milic, N., Focà, A. and Abe-navoli, L. (2015) Adiponectin Serum Level in Chronic Hepatitis C Infection and Therapeutic Profile. World Journal of Hepatology, 7, 44-52. [Google Scholar] [CrossRef] [PubMed]
[29] Hézode, C., Roudot-Thoraval, F., Zafrani, E.-S., Dhumeaux, D. and Pawlotsky, J.-M. (2004) Different Mechanisms of Steatosis in Hepatitis C Virus Genotypes 1 and 3 Infections. Journal of Viral Hepatitis, 11, 455-458. [Google Scholar] [CrossRef] [PubMed]
[30] Rubbia-Brandt, L., Quadri, R., Abid, K., Giostra, E., Malé, P.J., Mentha, G., Spahr, L., Zarski, J.P., Borisch, B., Hadengue, A. and Negro, F. (2000) Hepatocyte Steatosis Is a Cy-topathic Effect of Hepatitis C Virus Genotype 3. Journal of Hepatology, 33, 106-115. [Google Scholar] [CrossRef
[31] Papageorgiou, L., Vlachakis, C., Dragoumani, K., Raftopoulou, S., Brouzas, D., Nicolaides, N.C., Chrousos, G.P., Charmandari, E., Megalooikonomou, V. and Vlachakis, D. (2017) HCV Genetics and Genotypes Dictate Future Antiviral Strategies. Journal of Molecular Biochemistry, 6, 33-40.
[32] 赵鹏, 王磊. 聚乙二醇化干扰素-α对不同基因型慢性丙型肝炎患者治疗效果比较[J]. 实用肝脏病杂志, 2019, 22(1): 57-60.
[33] Moradpour, D., Brass, V., Gosert, R., Wölk, B. and Blum, H.E. (2002) Hepatitis C: Mo-lecular Virology and Antiviral Targets. Trends in Molecular Medicine, 8, 476-482. [Google Scholar] [CrossRef
[34] Di Biagio, A., Taramasso, L. and Cenderello, G. (2018) Treatment of Hepatitis C Virus Genotype 4 in the DAA Era. Virology Journal, 15, Article No. 180. [Google Scholar] [CrossRef] [PubMed]