P-糖蛋白在肿瘤中的研究新进展
New Research Progress of P-Glycoprotein in Tumor
DOI: 10.12677/WJCR.2023.134022, PDF,    科研立项经费支持
作者: 邹 青, 吕 圆*:湖南环境生物职业技术学院医药技术学院,湖南 衡阳
关键词: P-糖蛋白肿瘤药物P-Glycoprotein Tumor Drug
摘要: P-糖蛋白是一种位于细胞膜上,对疏水性及两性化合物具有特异性的一类转运蛋白。在生理条件下,P-糖蛋白分布在机体内多种组织、器官中,在药物的吸收、分布、代谢及排泄过程中都发挥着重要的作用。P-糖蛋白广泛存在于各种肿瘤细胞,与其发展密切相关。P-糖蛋白可加速机体抗癌药物产生耐药,调控P-糖蛋白水平可以调控肿瘤的发展和减少肿瘤药物耐药性。
Abstract: P-glycoprotein is a kind of transporter which is located on the cell membrane and has specificity for hydrophobic and amphoteric compounds. Under physiological conditions, P-glycoprotein is distributed in various tissues and organs in the body, and plays an important role in the absorption, distribution, metabolism and excretion of drugs. P-glycoprotein exists widely in various tumor cells and is closely related to its development. P-glycoprotein can accelerate anti-cancer drug resistance in the body, and regulate P-glycoprotein level which can regulate tumor development and reduce drug resistance.
文章引用:邹青, 吕圆. P-糖蛋白在肿瘤中的研究新进展[J]. 世界肿瘤研究, 2023, 13(4): 155-163. https://doi.org/10.12677/WJCR.2023.134022

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