环境中邻苯二甲酸酯的研究进展
Research Progress of Phthalates in the Environment
DOI: 10.12677/AEP.2023.136154, PDF,    科研立项经费支持
作者: 姚圆圆：天津大学环境科学与工程学院，天津；谱尼测试集团股份有限公司，北京；贾秀平：谱尼测试集团股份有限公司，北京；李振国, 李凯祥, 邵元凯, 任晓宁：移动源污染排放控制技术国家工程实验室，天津；鲁逸人：天津大学环境科学与工程学院，天津
关键词: 邻苯二甲酸酯；生物毒性；污染分布；人体暴露；Phthalates； Biological Toxicity； Pollution Characteristic； Human Exposure
摘要: 邻苯二甲酸酯类物质(PAEs)在环境中广泛存在，主要是作为增塑剂应用于化妆品和装修材料等工业和日常生活产品中。随着经济的快速发展，人们处于室内的时间越来越长，所使用的保养品也越来越多，且接触频率非常高。因此，研究环境中PAEs的污染水平，对人类健康的风险评价有着重要意义。本文介绍了PAEs的应用现状，综述了其人体健康危害与环境污染分布。同时，分析讨论了PAEs的室内暴露途径，并展望其未来的发展趋势。
Abstract: Phthalates (PAEs) widely exist in the environment and are mainly used as plasticizers in industrial and living products, such as cosmetics and decoration materials. With the rapid economic develop-ment, people spend more time indoors and use skin care products more frequently. Therefore, it is of great significance to study the pollution level of PAEs in the environment for risk assessment of human health. This paper introduces the application status of PAEs and summarizes their human health hazards and environmental pollution distribution. Meanwhile, the indoor exposure pathways of PAEs are also analyzed and discussed, and their future development trends have prospected.
文章引用：姚圆圆, 贾秀平, 李振国, 李凯祥, 邵元凯, 任晓宁, 鲁逸人. 环境中邻苯二甲酸酯的研究进展[J]. 环境保护前沿, 2023, 13(6): 1281-1287. https://doi.org/10.12677/AEP.2023.136154

参考文献

[1] (2011) Plastic Wall Materials in the Home and Respiratory Health in Young Children. American Journal of Public Health, 90, 797-799. [Google Scholar] [CrossRef] 
[2] Kolarik, B., Naydenov, K., Larsson, M., Bornehag, C.G. and Sundell, J. (2008) The Association between Phthalates in Dust and Allergic Diseases among Bulgarian Children. Environmental Health Perspectives, 116, 98-103. [Google Scholar] [CrossRef] [PubMed]
[3] Newbold, R.R., Padilla-Banks, E., Snyder, R.J., Phillips, T.M. and Jef-ferson, W.N. (2007) Developmental Exposure to Endocrine Disruptors and the Obesity Epidemic. Reproductive Toxi-cology, 23, 290-296. [Google Scholar] [CrossRef] [PubMed]
[4] Guo, Y. and Kannan, K. (2011) Comparative Assessment of Human Exposure to Phthalate Esters from House Dust in China and the United States. Environmental Science & Technology, 45, 3788-3794. [Google Scholar] [CrossRef] [PubMed]
[5] Bu, Z., Zhang, Y., Mmereki, D., et al. (2016) Indoor Phthalate Concentration in Residential Apartments in Chongqing, China: Implications for Preschool Children’s Exposure and Risk Assessment. Atmospheric Environment, 127, 34-45. [Google Scholar] [CrossRef] 
[6] Mondal, T., Mondal, S., Ghosh, S.K., et al. (2022) Phthalates—A Family of Plasticizers, Their Health Risks, Phytotoxic Effects, and Microbial Bioaugmentation Ap-proaches. Environmental Research, 214, Article ID: 114059. [Google Scholar] [CrossRef] [PubMed]
[7] Angnunavuri, P.N., Attiogbe, F. and Mensah, B. (2022) Effect of Storage on the Levels of Phthalates in High-Density Polyethylene (HDPE) Film-Packaged Drinking Water. Science of the Total Environment, 845, Article ID: 157347. [Google Scholar] [CrossRef] [PubMed]
[8] Liu, S., Yang, R., Yang, Q., et al. (2022) The Independent and Interactive Effects of Phthalates Exposure and Hypertension on the Indicators of Early Renal Injury in US Adults: Evidence from NHANES 2001-2004. Environmental Research, 213, Article ID: 113733. [Google Scholar] [CrossRef] [PubMed]
[9] Zhu, C., Sun, Y., Zhao, Y., et al. (2022) Associations between Children’s Asthma and Allergic Symptoms and Phthalates in Dust in Metropolitan Tianjin, China. Chemosphere, 302, Article ID: 134786. [Google Scholar] [CrossRef] [PubMed]
[10] Hua, L., Guo, S., Xu, J., et al. (2022) Phthalates in Dormitory Dust and Human Urine: A Study of Exposure Characteristics and Risk Assessments of University Students. Science of the Total Environment, 845, Article ID: 157251. [Google Scholar] [CrossRef] [PubMed]
[11] Simoneit, B., Medeiros, P.M. and Didyk, B.M. (2005) Combustion Products of Plastics as Indicators for Refuse Burning in the Atmosphere. Environmental Science & Tech-nology, 39, 6961-6970. [Google Scholar] [CrossRef] [PubMed]
[12] Schettler, T. (2006) Human Exposure to Phthalates via Consumer Products. International Journal of Andrology, 29, 134-139. [Google Scholar] [CrossRef] [PubMed]
[13] Net, S., Sempere, R., Delmont, A., et al. (2015) Occurrence, Fate, Behavior and Ecotoxicological State of Phthalates in Different Environmental Matrices. Environmental Science & Technology, 49, 4019-4035. [Google Scholar] [CrossRef] [PubMed]
[14] Guo, Y. and Kannan, K. (2013) A Survey of Phthalates and Parabens in Personal Care Products from the United States and Its Implications for Human Exposure. Environmental Science & Technology, 47, 14442-14449. [Google Scholar] [CrossRef] [PubMed]
[15] Koniecki, D., Rong, W., Moody, R.P. and Zhu, J.P. (2011) Phthalates in Cosmetic and Personal Care Products: Concentrations and Possible Dermal Exposure. Environmental Research, 111, 329-336. [Google Scholar] [CrossRef] [PubMed]
[16] Mcdonald, A. (1995) Some Industrial Chemicals: IARC Mon-ographs on the Evaluation of Carcinogenic Risks to Humans. Vol 60. Occupational & Environmental Medicine, 52, 360. [Google Scholar] [CrossRef] 
[17] 张蕴晖. 邻苯二甲酸二乙基己酯对环境和生物体的危害[J]. 环境卫生学杂志, 2002, 29(2): 73-77.
[18] Wei, X., Wan, H.T., Zhao, Y.G., et al. (2011) Effects of Perinatal Exposure to Bisphenol A and Di(2-Ethylhexyl)-Phthalate on Gonadal Development of Male Mice. Environmental Science & Pollution Research, 19, 2515-2527. [Google Scholar] [CrossRef] [PubMed]
[19] Anderson, D., Yu, T.W. and Hinal, F. (1999) Effect of Some Phthalate Esters in Human Cells in the Comet Assay. Teratogenesis Carcinogenesis and Mutagenesis, 19, 275-280. [Google Scholar] [CrossRef] 
[20] 高丽芳, 李勇, 苏忆兰. 邻苯二甲酸二-(2-乙基己基)酯对小鼠胚胎致畸作用和心肌细胞的毒性[J]. 毒理学杂志, 2005, 19(2): 123-124.
[21] Thompson, C.J., Ross, S.M. and Gaido, K.W. (2004) Di(n-Butyl) Phthalate Impairs Cholesterol Transport and Steroidogenesis in the Fetal Rat Testis through a Rapid and Reversible Mechanism. Endocrinology, 3, 1227-1237. [Google Scholar] [CrossRef] [PubMed]
[22] Saillenfait, A.M., Langonné, I. and Leheup, B. (2010) Effects of Mono-n-Butyl Phthalate on the Development of Rat Embryos: In vivo and in vitro Observations. Basic & Clinical Pharmacology & Toxicology, 89, 104-112. [Google Scholar] [CrossRef] 
[23] Ema, M. and Miyawaki, E. (2001) Adverse Effects on Development of the Reproductive System in Male Offspring of Rats Given Monobutyl Phthalate, a Metabolite of Dibutyl Phthalate, during late Pregnancy. Reproductive Toxicology, 15, 189-194. [Google Scholar] [CrossRef] 
[24] Bornehag, C.G., Sundell, J., Weschler, C.J., et al. (2004) The Association between Asthma and Allergic Symptoms in Children and Phthalates in House Dust: A Nested Case-Control Study. Environmental Health Perspectives, 112, 1393-1397. [Google Scholar] [CrossRef] [PubMed]
[25] Stahlhut, R.W., Wijngaarden, E.V., Dye, T.D., et al. (2007) Concentrations of Urinary Phthalate Metabolites Are Associated with Increased Waist Circumference and Insulin Resistance in Adult U.S. Males. Environmental Health Perspectives, 115, 876-882. [Google Scholar] [CrossRef] [PubMed]
[26] Swan, S.H., Main, K.M., Fan, L., et al. (2005) Decrease in Anogenital Distance among Male Infants with Prenatal Phthalate Exposure. Environmental Health Perspectives, 113, 1056-1061. [Google Scholar] [CrossRef] [PubMed]
[27] Kanazawa, A., Saito, I., Araki, A., et al. (2010) Association between Indoor Exposure to Semi-Volatile Organic Compounds and Building-Related Symptoms among the Occupants of Residential Dwellings. Indoor Air, 20, 72-84. [Google Scholar] [CrossRef] [PubMed]
[28] Zhang, Y., Jiao, Y., Li, Z., et al. (2021) Hazards of Phthalates (PAEs) Exposure: A Review of Aquatic Animal Toxicology Studies. Science of the Total Environment, 771, Article ID: 145418. [Google Scholar] [CrossRef] [PubMed]
[29] Guo, W. (1997) Analysis of Phthalate Esters in Urban Air and Plastic Greenhouse Air. Environmental Chemistry, 13, 557-560.
[30] Feng, Z., Cui, K., Xie, Z., et al. (2009) Dis-tribution of Phthalate Esters in Urban Soils of Subtropical City, Guangzhou, China. Journal of Hazardous Materials, 164, 1171-1178. [Google Scholar] [CrossRef] [PubMed]
[31] 陈丽旋, 曾锋, 罗丹玲. 城市道路灰尘中邻苯二甲酸酯污染特征研究[J]. 环境科学学报, 2005, 25(3): 409-413.
[32] Nanni, N., Fiselier, K., Grob, K., et al. (2011) Contamination of Vegetable Oils Marketed in Italy by Phthalic Acid Esters. Food Control, 22, 209-214. [Google Scholar] [CrossRef] 
[33] Ying, X.U., Hual, E.A.C., Clausen, P.A. and Little, J.C. (2009) Predicting Residential Exposure to Phthalate Plasticizer Emitted from Vinyl Flooring: A Mechanistic Analysis. Environmental Science & Technology, 43, 2374-2380. [Google Scholar] [CrossRef] [PubMed]
[34] Wei, W., Wu, F.Y., Huang, M.J., et al. (2013) Size Fraction Effect on Phthalate Esters Accumulation, Bioaccessibility and in vitro Cytotoxicity of Indoor/Outdoor Dust, and Risk Assessment of Human Exposure. Journal of Hazardous Materials, 261, 753-762. [Google Scholar] [CrossRef] [PubMed]
[35] Weschler, C.J. and Nazaroff, W.W. (2008) Semivolatile Organic Compounds in Indoor Environments. Atmospheric Environment, 42, 9018-9040. [Google Scholar] [CrossRef] 
[36] Wang, X., Wei, T., Xu, Y., Feng, J.T. and Wang, F.H. (2014) Indoor Phthalate Concentration and Exposure in Residential and Office Buildings in Xi’an, China. Atmospheric Envi-ronment, 87, 146-152. [Google Scholar] [CrossRef] 
[37] Clark, K.E., David, R.M., Guinn, R., et al. (2011) Modeling Human Exposure to Phthalate Esters: A Comparison of Indirect and Biomonitoring Estimation Methods. Human & Ecological Risk Assessment: An International Journal, 17, 923-965. [Google Scholar] [CrossRef] [PubMed]
[38] Guney, M. and Zagury, G.J. (2011) Toxic Chemicals in Toys and Children’s Products. Environmental Science & Technology, 45, 3819. [Google Scholar] [CrossRef] [PubMed]
[39] Agency for Toxic Substances and Disease Registry (ATSDR) (1992) Public Health Assessment Guidance Manual. Chemosphere, 31, 2437-2454.
[40] Gabriel, B., Weschler, C.J., Sarka, L., et al. (2013) Children’s Phthalate Intakes and Resultant Cumulative Exposures Estimated from Urine Compared with Estimates from Dust Ingestion, Inhalation and Dermal Absorption in Their Homes and Daycare Centers. PLOS ONE, 8, e62442. [Google Scholar] [CrossRef] [PubMed]
[41] Fromme, H., Lahrz, T., Kraft, M., et al. (2013) Phthalates in German Daycare Centers: Occurrence in Air and Dust and the Excretion of Their Metabolites by Children (LUPE 3). Environment International, 61, 64-72. [Google Scholar] [CrossRef] [PubMed]