土茯苓及其有效成分治疗风湿骨病的研究进展

Research Progress on the Treatment of Rheumatic Bone Disease with Tufuling and Its Effective Ingredients

摘要: 风湿骨病主要是由于正气虚弱，风寒湿等邪气乘虚侵袭，痹阻经络，引起关节肿胀疼痛、屈伸不利、功能障碍的疾病，后期可出现关节致残和(或)内脏功能衰竭。已有较多文献报道土茯苓特别是落新妇苷在治疗风湿骨病方面具有独特的抗炎抗氧化、调节免疫等作用，本文就其在风湿骨病中作用机制的研究进展作一综述，为进一步开发利用和研发新药提供科学依据。

Abstract: Rheumatic bone disease is mainly caused by the weakness of the positive qi, invasion of evil qi such as wind, cold, and dampness, obstruction of the meridians, causing joint swelling, pain, poor flexion and extension, and dysfunction. In the later stage, joint disability and/or visceral dysfunction may occur. There have been many literature reports on the unique anti-inflammatory, antioxidant and immune regulatory effects of Tufuling, especially Astilbin, in the treatment of rheumatic bone dis-ease. This article reviews the research progress of its mechanism of action in rheumatic bone dis-ease, providing scientific basis for further development, utilization, and research and development of new drugs.