新型冠状病毒感染对凝血功能、肝功能及心功能影响的研究进展
Research Progress on the Influence of Novel Coronavirus Infection on Coagulation Function, Liver Function and Cardiac Function
摘要: 检测新型冠状病毒感染(COVID-19，以下简称新冠)患者血中凝血指标、肝功能指标及心功能指标数值，探究这些指标在预测新冠严重程度中的价值，将这些指标作为新的潜在参数来区分重症新冠患者和非重症患者，对重症患者进行早期干预治疗，以此来控制疾病进展、降低入住重症监护室率和死亡率。本文将从新冠常见实验室指标对重症和非重症新冠患者的预测价值方面做一综述。
Abstract: To detect the blood coagulation index, liver function index and cardiac function index of patients with novel coronavirus infection (COVID-19, hereinafter referred to as COVID-19), and to explore the value of these indexes in predicting the severity of COVID-19, these indicators are regarded as new potential parameters to distinguish severe COVID-19 patients from non-severe patients, and early intervention treatment should be given to severe patients, so as to control the disease progress and reduce the rate of admission to intensive care unit and mortality. This article will summarize the predictive value of common laboratory indexes of new crown for severe and non-severe COVID-19 patients.
文章引用：胡国佳, 齐博旭, 孙宝华. 新型冠状病毒感染对凝血功能、肝功能及心功能影响的研究进展[J]. 临床医学进展, 2024, 14(2): 3693-3701. https://doi.org/10.12677/ACM.2024.142515

参考文献

[1] Malik, Y.S., Sircar, S., Bhat, S., et al. (2020) Emerging Novel Coronavirus (2019-NCoV)-Current Scenario, Evolu-tionary Perspective Based on Genome Analysis and Recent Developments. The Veterinary Quarterly, 40, 68-76. [Google Scholar] [CrossRef] [PubMed]
[2] Hu, B., Guo, H., Zhou, P., et al. (2021) Characteristics of SARS-CoV-2 and COVID-19. Nature Reviews Microbiology, 19, 141-154. [Google Scholar] [CrossRef] [PubMed]
[3] Rehman, U.S., Shafique, L., Ihsan, A., et al. (2020) Evolutionary Trajectory for the Emergence of Novel Coronavirus SARS-CoV-2. Pathogens, 9, 240-240. [Google Scholar] [CrossRef] [PubMed]
[4] Goh, K.G., Dunker, K.A., Foster, A.J., et al. (2020) Shell Disorder Analysis Predicts Greater Resilience of the SARS-CoV-2 (COVID-19) outside the Body and in Body Fluids. Microbial Pathogenesis, 144, Article ID: 104177. [Google Scholar] [CrossRef] [PubMed]
[5] Petersen, E., Koopmans, M., Go, U., et al. (2020) Comparing SARS-CoV-2 with SARS-CoV and Influenza Pandemics. The Lancet Infectious Diseases, 20, E238-E244. [Google Scholar] [CrossRef] 
[6] Wu, F., Zhao, S., Yu, B., et al. (2020) A New Coronavirus Associated with Human Respiratory Disease in China. Nature, 579, 265-269. [Google Scholar] [CrossRef] [PubMed]
[7] De Giorgio, A. (2020) Global Psychological Implications of Se-vere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease-2019 (COVID-19). What Can Be Learned from Italy. Reflections, Perspectives, Opportunities. Frontiers in Psychology, 11, Article No. 1836.
[8] Nikolich-Zugich, J., Knox, K.S., Rios, C., et al. (2020) Correction to: SARS-CoV-2 and COVID-19 in Older Adults: What We May Expect Regarding Pathogenesis, Immune Responses, and Outcomes. GeroScience, 42, Arti-cle No. 1013. [Google Scholar] [CrossRef] [PubMed]
[9] 丁彦青, 卞修武. 从SARS尸体解剖发现, 浅析冠状病毒性疾病-19(COVID-19) [J]. 中华病理学杂志, 2020(49): e003.
[10] Mahmudpour, M., Roozbeh, J., Keshavarz, M., et al. (2020) COVID-19 Cytokine Storm: The Anger of Inflammation. Cytokine, 133, Article ID: 155151. [Google Scholar] [CrossRef] [PubMed]
[11] Ni, W., et al. (2020) Role of Angiotensin-Converting Enzyme 2 (ACE2) in COVID-19. Critical Care (London, England), 24, Article No. 422. [Google Scholar] [CrossRef] [PubMed]
[12] Narayan, A., et al. (2020) Pathophysiology of COVID-19-Associated Acute Respiratory Distress Syndrome. The Lancet Respiratory Medicine, 9, E3. [Google Scholar] [CrossRef] 
[13] Gusev, E., Sarapultsev, A., Hu, D. and Chereshnev, V. (2021) Problems of Pathogenesis and Pathogenetic Therapy of COVID-19 from the Perspective of the General Theory of Pathological Systems (General Pathological Processes). International Journal of Molecular Sciences, 22, 7582-7582. [Google Scholar] [CrossRef] [PubMed]
[14] Asakura, H. and Ogawa, H. (2020) COVID-19-Associated Coag-ulopathy and Disseminated Intravascular Coagulation. International Journal of Hematology, 113, 45-57. [Google Scholar] [CrossRef] [PubMed]
[15] Dhama, K., Khan, S., Tiwari, R., et al. (2020) Coronavirus Disease 2019-COVID-19. Clinical Microbiology Reviews, 33, e00028-20. [Google Scholar] [CrossRef] 
[16] Lu, R.J., Zhao, X., Li, J., et al. (2020) Genomic Characterisation and Epidemiology of 2019 Novel Coronavirus: Implications for Virus Origins and Receptor Binding. The Lancet, 395, 565-574.
[17] Meini, S., Zanichelli, A., Sbrojavacca, R., et al. (2020) Understanding the Pathophysiology of COVID-19: Could the Contact System Be the Key? Frontiers in Immunology, 11, Article No. 2014.
[18] Jin, Y., Yang, H., Ji, W., et al. (2020) Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses, 12, Article No. 372. [Google Scholar] [CrossRef] [PubMed]
[19] Nooh, F., Utzinger, J., Paris, D.H., et al. (2023) Association of Hyper-tension, Diabetes, and Cardiovascular Disease with COVID-19 in Africa: Scoping Review Protocol. Tropical Medicine and Infectious Disease, 8, Article No. 293. [Google Scholar] [CrossRef] [PubMed]
[20] Huang, C., Wang, Y., Li, X., et al. (2020) Clinical Features of Patients Infected with 2019 Novel Coronavirus in Wuhan, China. The Lancet, 395, 497-506. [Google Scholar] [CrossRef] 
[21] Levi, M. and Scully, M. (2018) How I Treat Disseminated Intravascular Coagulation. Blood, 131, 845-854. [Google Scholar] [CrossRef] [PubMed]
[22] Liu, Y., Gao, W., Guo, W., et al. (2020) Prominent Coagula-tion Disorder Is Closely Related to Inflammatory Response and Could Be as a Prognostic Indicator for ICU Patients with COVID-19. Journal of Thrombosis and Thrombolysis, 50, 825-832. [Google Scholar] [CrossRef] [PubMed]
[23] Chen, A.-T., Wang, C.-Y., Zhu, W.-L., et al. (2022) Coagulation Disorders and Thrombosis in COVID-19 Patients and a Possible Mechanism Involving Endothelial Cells: A Review. Aging and Disease, 13, 144-156. [Google Scholar] [CrossRef] 
[24] Mucha, S.R., Dugar, S., et al. (2020) Update to Coagulopathy in COVID-19: Manifestations and Management. Cleveland Clinic Journal of Medicine.
[25] Cui, S.P., Chen, S., Li, X.N., et al. (2020) Prevalence of Venous Thromboembolism in Patients with Severe Novel Coronavirus Pneumonia. Journal of Thrombosis and Haemostasis: JTH, 18, 1421-1424. [Google Scholar] [CrossRef] [PubMed]
[26] Klok, F., Kruip, M., Meer, D.V.N., et al. (2020) Incidence of Thrombotic Complications in Critically Ill ICU Patients with COVID-19. Thrombosis Research, 191, 145-147. [Google Scholar] [CrossRef] [PubMed]
[27] Middeldorp, S., Coppens, M., Van Haaps, T.F., et al. (2021) Incidence of Venous Thromboembolism in Hospitalized Patients with COVID-19. Journal of Vascular Surgery: Venous and Lymphatic Disorders, 9, Article No. 536. [Google Scholar] [CrossRef] 
[28] Kollias, A., Kyriakoulis, K.G., et al. (2020) Thromboembolic Risk and Anticoagulant Therapy in COVID-19 Patients: Emerging Evidence and Call for Action. British Journal of Haematology, 189, 846-847. [Google Scholar] [CrossRef] [PubMed]
[29] Arachchillage, D.R.J. and Laffan, M. (2020) Abnormal Coagulation Pa-rameters Are Associated with Poor Prognosis in Patients with Novel Coronavirus Pneumonia. Journal of Thrombosis and Haemostasis: JTH, 18, 1233-1234. [Google Scholar] [CrossRef] [PubMed]
[30] Mamta, S., Ram, G., Raju, V., et al. (2020) D-Dimer Level Is a Useful Pre-dictor for Mortality in Patients with COVID-19: Analysis of 483 Cases. Diabetes Metabolic Syndrome: Clinical Re-search Reviews, 14, 2245-2249. [Google Scholar] [CrossRef] [PubMed]
[31] Rostami, M. and Mansouritorghabeh, H. (2020) D-Dimer Level in COVID-19 Infection: A Systematic Review. Expert Review of Hematology, 13, 1265-1275. [Google Scholar] [CrossRef] [PubMed]
[32] Chawda, N., Jain, S., Solanki, B., et al. (2023) D-Dimer: A Primer Biomarker in COVID-19. Asian Journal of Medicine and Health, 21, 107-113. [Google Scholar] [CrossRef] 
[33] Tahir, M.J., Yasmin, F., et al. (2023) Association of D-Dimer Levels with In-Hospital Outcomes among COVID-19 Positive Patients: A Developing Country Multicenter Retrospec-tive Cohort. Annals of Medicine and Surgery (2012), 85, 1527-1533.
[34] Hayıroğlu, M.İ., et al. (2020) Fibrinogen and D-Dimer Variances and Anticoagulation Recommendations in Covid-19: Current Literature Review. Revista Da Associacao Medica Brasileira (1992), 66, 842-848. [Google Scholar] [CrossRef] [PubMed]
[35] Levi, M., et al. (2009) Guidelines for the Diagnosis and Man-agement of Disseminated Intravascular Coagulation. British Committee for Standards in Haematology. British Journal of Haematology, 145, 24-33. [Google Scholar] [CrossRef] [PubMed]
[36] Han, H., Yang, L., Liu, R., et al. (2020) Prominent Changes in Blood Coagulation of Patients with SARS-CoV-2 Infection. Clinical Chemistry and Laboratory Medicine, 58, 1116-1120. [Google Scholar] [CrossRef] [PubMed]
[37] Di Micco, P., Russo, V., Carannante, N., et al. (2020) Prognostic Value of Fibrinogen among COVID-19 Patients Admitted to an Emergency Department: An Italian Cohort Study. Journal of Clinical Medicine, 9, Article No. 4134. [Google Scholar] [CrossRef] [PubMed]
[38] Sui, J.R., Noubouossie, D.F., et al. (2021) Elevated Plasma Fibrinogen Is Associated with Excessive Inflammation and Disease Severity in COVID-19 Patients. Frontiers in Cellular and Infection Microbiology, 11, Article ID: 734005. [Google Scholar] [CrossRef] [PubMed]
[39] Citu, C., Burlea, B., Gorun, F., et al. (2022) Predictive Value of Blood Coagulation Parameters in Poor Outcomes in COVID-19 Patients: A Retrospective Observational Study in Ro-mania. Journal of Clinical Medicine, 11, 2831-2831. [Google Scholar] [CrossRef] [PubMed]
[40] Papadopoulos, N., Vasileiadi, S. and Deutsch, M. (2020) COVID-19 and Liver Injury: Where Do We Stand? Annals of Gastroenterology, 33, 459-464.
[41] Sivandzadeh, G.R., Askari, H., Safarpour, A.R., et al. (2021) COVID-19 Infection and Liver Injury: Clinical Features, Biomarkers, Potential Mecha-nisms, Treatment, and Management Challenges. World Journal of Clinical Cases, 9, 6178-6200. [Google Scholar] [CrossRef] [PubMed]
[42] Mustafa, I.M., Abdelmoneim, H.A., Mahmoud, M.E., et al. (2020) Cytokine Storm in COVID-19 Patients, Its Impact on Organs and Potential Treatment by QTY Code-Designed Deter-gent-Free Chemokine Receptors. Mediators of Inflammation, 2020, Article ID: 8198963. [Google Scholar] [CrossRef] 
[43] Ali, F.E.M., Mohammedsaleh, Z.M., Ali, M.M., et al. (2021) Impact of Cytokine Storm and Systemic Inflammation on Liver Impairment Patients Infected by SARS-CoV-2: Prospective Therapeutic Challenges. World Journal of Gastroenterology, 27, 1531-1552. [Google Scholar] [CrossRef] [PubMed]
[44] Fan, Z., Chen, L., Li, J., et al. (2020) Clinical Features of COVID-19-Related Liver Functional Abnormality. Clinical Gastroenterology and Hepatology, 18, 1561-1566. [Google Scholar] [CrossRef] [PubMed]
[45] Harapan, H., Karunia, J.F., Supriono, S., et al. (2021) The Preva-lence, Predictors and Outcomes of Acute Liver Injury among Patients with COVID-19: A Systematic Review and Me-ta-Analysis. Reviews in Medical Virology, 32, e2304.
[46] Wong, J.Y., Tan, M., Zheng, Q., et al. (2020) A Systematic Review and Meta-Analysis of the COVID-19 Associated Liver Injury. Annals of Hepatology, 19, 627-634. [Google Scholar] [CrossRef] [PubMed]
[47] Dong, X., Zeng, D.-Y., Xing, Q.-Q., et al. (2022) Liver Chem-istries in Severe or Non-Severe Cases of COVID-19: A Systematic Review and Meta-Analysis. World Journal of Hepatology, 14, 2012-2024. [Google Scholar] [CrossRef] [PubMed]
[48] Kheir, M., et al. (2021) Higher Albumin Levels on Admission Predict Better Prognosis in Patients with Confirmed COVID-19. PLOS ONE, 16, e0248358. [Google Scholar] [CrossRef] [PubMed]
[49] Zekri-Nechar, K., Zamorano-León, J.J., Segura-Fragoso, A., et al. (2022) Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose. Journal of Clinical Medicine, 11, 587. [Google Scholar] [CrossRef] [PubMed]
[50] Ertekin, B. and Acar, T. (2023) The Relationship between Albumin and Its Proportion to Other Markers in Predicting Mortality in Severe COVID-19 Patients. European Review for Medical and Pharmacological Sciences, 27, 6429-6436.
[51] Xie, C.Y., Wang, S.J., Zhou, J., et al. (2022) Albumin Level as an Independent Predictive Factor for Adverse Outcomes in COVID-19 Patients: A Retrospective Cohort Study. Journal of Infection in Developing Countries, 16, 1696-1702. [Google Scholar] [CrossRef] [PubMed]
[52] Yao, X.H., Li, T.Y., He, Z.C., et al. (2020) A Pathological Report of Three COVID-19 Cases by Minimal Invasive Autopsies. Chinese Journal of Pathology, 49, 411-417.
[53] Tavazzi, G., Pellegrini, C., Maurelli, M., et al. (2020) Myocardial Localization of Coronavirus in COVID-19 Cardiogenic Shock. European Journal of Heart Failure, 22, 911-915. [Google Scholar] [CrossRef] [PubMed]
[54] Rahman, T., Al-Ishaq, F.A., Al-Mohannadi, F.S., et al. (2021) Mortality Prediction Utilizing Blood Biomarkers to Predict the Severity of COVID-19 Using Machine Learning Technique. Diagnostics, 11, 1582-1582. [Google Scholar] [CrossRef] [PubMed]
[55] Ozenen, G.G., Kara, A.A., Kiymet, E., et al. (2022) The Eval-uation of Troponin I Levels and Myocarditis in Children with COVID-19: A Pediatric Single-Center Experience. Pedi-atric Cardiology, 44, 873-881. [Google Scholar] [CrossRef] [PubMed]
[56] Patel, T., Kelleman, M., West, Z., et al. (2022) Comparison of Multisystem Inflammatory Syndrome in Children-Related Myocarditis, Classic Viral Myocarditis, and COVID-19 Vac-cine-Related Myocarditis in Children. Journal of the American Heart Association, 11, e024393. [Google Scholar] [CrossRef] 
[57] Lara, D., Young, T., Del Toro, K., et al. (2020) Acute Fulminant Myocarditis in a Pediatric Patient with COVID-19 Infection. Pediatrics, 146, e20201509. [Google Scholar] [CrossRef] [PubMed]
[58] Sirico, D., Basso, A., Sabatino, J., et al. (2022) Evolution of Echo-cardiographic and Cardiac Magnetic Resonance Imaging Abnormalities during Follow-Up in Patients with Multisystem Inflammatory Syndrome in Children. European Heart Journal. Cardiovascular Imaging, 23, 1066-1074. [Google Scholar] [CrossRef] [PubMed]
[59] Güllü, U.U., Güngör, Ş., İpek, S., et al. (2021) Predictive Value of Cardiac Markers in the Prognosis of COVID-19 in Children. American Journal of Emergency Medicine, 48, 307-311. [Google Scholar] [CrossRef] [PubMed]
[60] Rodriguez-Gonzalez, M., Castellano-Martinez, A., Maria Cascales-Poyatos, H., et al. (2020) Cardiovascular Impact of COVID-19 with a Focus on Children: A Systematic Re-view. World Journal of Clinical Cases, 8, 5250-5283. [Google Scholar] [CrossRef] [PubMed]
[61] Liu, A., et al. (2023) Normal High-Sensitivity Cardiac Troponin for Ruling-Out Inpatient Mortality in Acute COVID-19. PLOS ONE, 18, e0284523. [Google Scholar] [CrossRef] [PubMed]
[62] Gupta, P., Gupta, A., Bansal, S. and Balakrishnan, I. (2023) Cardiac Troponin in Hospitalized COVID-19 Patients: Incidence, Predictors, and Outcomes. Annals of Clinical Bio-chemistry.
[63] Orlando, L., et al. (2023) Natural Course of COVID-19 and Independent Predictors of Mortality. Bio-medicines, 11, 939-939. [Google Scholar] [CrossRef] [PubMed]
[64] Cilingir, B.M., Askar, S., Meral, A. and Askar, M. (2022) Can B-Type Natriuretic Peptide (BNP) Levels Serve as an Early Predictor of Clinical Severity in Patients with COVID-19 Pneumonia? Clinical Laboratory, 68, No. 1. [Google Scholar] [CrossRef] 
[65] Fawzy, M., Ahmed, S.S. and Abdelhady, S.A. (2023) As-sessment of Diagnostic and Prognostic Laboratory Biomarkers in Severe COVID-19 Patients Admitted to Intensive Care Unit. The Egyptian Journal of Immunology, 30, 11-13. [Google Scholar] [CrossRef] 

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