|
[1]
|
Wahli, W., Braissant, O. and Desvergne, B. (1995) Peroxisome Proliferator Activated Receptors: Transcriptional Regulators of Adipogenesis, Lipid Metabolism and More. Chemistry & Biology, 2, 261-266. [Google Scholar] [CrossRef] [PubMed]
|
|
[2]
|
Kuenzli, S. and Saurat, J.H. (2003) Peroxisome Proliferator-Activated Receptors in Cutaneous Biology. British Journal of Dermatology, 149, 229-236. [Google Scholar] [CrossRef] [PubMed]
|
|
[3]
|
Venteclef, N., Jakobsson, T., Steffensen, K.R. and Treuter, E. (2011) Metabolic Nuclear Receptor Signaling and the Inflammatory Acute Phase Response. Trends in Endocrinology & Metabolism, 22, 333-343. [Google Scholar] [CrossRef] [PubMed]
|
|
[4]
|
Issemann, I. and Green, S. (1990) Activation of a Member of the Steroid Hormone Receptor Superfamily by Peroxisome Proliferators. Nature, 347, 645-650. [Google Scholar] [CrossRef] [PubMed]
|
|
[5]
|
Bougarne, N., Basiel, W., Sofie, J.D., et al. (2018) Molecular Actions of PPARα in Lipid Metabolism and Inflammation. Endocrine Reviews, 39, 760-802. [Google Scholar] [CrossRef] [PubMed]
|
|
[6]
|
Kersten, S., Seydoux, J., Peters, J.M., et al. (2014) Integrated Physiology and Systems Biology of PPARα. Molecular Metabolism, 3, 354-371. [Google Scholar] [CrossRef] [PubMed]
|
|
[7]
|
Kersten, S., (1990) Peroxisome Proliferator-Activated Receptor α Mediates the Adaptive Response to Fasting. Journal of Clinical Investigation, 103, 1489-1498. [Google Scholar] [CrossRef]
|
|
[8]
|
Settembre, C., Cegli, D.R., Mansueto, G., et al. (2013) TFEB Controls Cellular Lipid Metabolism through a Starvation-Induced Autoregulatory Loop. Nature Cell Biology, 15, 647-658. [Google Scholar] [CrossRef] [PubMed]
|
|
[9]
|
Sanderson, L.M., Boekschoten, M.V., Desvergne, B., et al. (2010) Transcriptional Profiling Reveals Divergent Roles of PPARα and PPARβ/Delta in Regulation of Gene Expression in Mouse Liver. Physiological Genomics, 41, 42-52. [Google Scholar] [CrossRef] [PubMed]
|
|
[10]
|
Sugden, M.C., Bulmer, K., Gibbons, G.F., et al. (2002) Peroxisome-Proliferator-Activated Receptor-α (PPARα) Deficiency Leads to Dysregulation of Hepatic Lipid and Carbohydrate Metabolism by Fatty Acids and Insulin. Biochemical Journal, 364, 361-368. [Google Scholar] [CrossRef] [PubMed]
|
|
[11]
|
Patsouris, D., Mandard, S., Voshol, P.J., et al. (2004) PPARα Governs Glycerol Metabolism. Journal of Clinical Investigation, 114, 94-103. [Google Scholar] [CrossRef]
|
|
[12]
|
Rakhshandehroo, M., Sanderson, L.M., Matilainen, M., et al. (2007) Comprehensive Analysis of PPARα-Dependent Regulation of Hepatic Lipid Metabolism by Expression Profiling. PPAR Research, 2007, Article ID: 26839. [Google Scholar] [CrossRef] [PubMed]
|
|
[13]
|
Xu, J., Chang, V., Joseph, S.B., et al. (2004) Peroxisomal Proliferator-Activated Receptor α Deficiency Diminishes Insulin-Responsiveness of Gluconeogenic/Glycolytic/Pentose Gene Expression and Substrate Cycle Flux. Endocrinology, 145, 1087-1095. [Google Scholar] [CrossRef] [PubMed]
|
|
[14]
|
Makowski, L., Noland, R.C., Koves, T.R., et al. (2009) Metabolic Profiling of PPARα-/- Mice Reveals Defects in Carnitine and Amino Acid Homeostasis That Are Partially Reversed by Oral Carnitine Supplementation. FASEB Journal, 23, 586-604. [Google Scholar] [CrossRef] [PubMed]
|
|
[15]
|
Kersten, S., Mandard, S., Escher, P., et al. (2001) The Peroxisome Proliferator-Activated Receptor α Regulates Amino Acid Metabolism. FASEB Journal, 15, 1971-1978. [Google Scholar] [CrossRef] [PubMed]
|
|
[16]
|
Chinetti, G., Zawadski, C., Fruchart, J.C. and Staels, B. (2004) Expression of Adiponectin Receptors in Human Macrophages and Regulation by Agonists of the Nuclear Receptors PPARα, PPARγ, and LXR. Biochemical and Biophysical Research Communications, 314, 151-158. [Google Scholar] [CrossRef] [PubMed]
|
|
[17]
|
Jones, D.C., Ding, X. and Daynes, R.A. (2002) Nuclear Receptor Peroxisome Proliferator-Activated Receptor α (PPARα) Is Expressed in Resting Murine Lymphocytes. The PPARα in T and B Lymphocytes Is Both Transactivation and Transrepression Competent. Journal of Biological Chemistry, 277, 6838-6845. [Google Scholar] [CrossRef]
|
|
[18]
|
Dunn, S.E., Ousman, S.S., Sobel, R.A., et al. (2007) Peroxisome Proliferator-Activated Receptor (PPAR)α Expression in T Cells Mediates Gender Differences in Development of T Cell-Mediated Autoimmunity. Journal of Experimental Medicine, 204, 321-330. [Google Scholar] [CrossRef] [PubMed]
|
|
[19]
|
Serrano-Marco, L., Rodriguez-Calvo, R., El Kochairi, I., et al. (2011) Activation of Peroxisome Proliferator-Activated Receptor-β/-Delta (PPAR-β/-Delta) Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in Interleukin-6-Stimulated Adipocytes. Diabetes, 60, 1990-1999. [Google Scholar] [CrossRef] [PubMed]
|
|
[20]
|
Burkart, E.M., Sambandam, N., Han, X., et al. (2007) Nuclear Receptors PPARβ/Delta and PPARα Direct Distinct Metabolic Regulatory Programs in the Mouse Heart. Journal of Clinical Investigation, 117, 3930-3939. [Google Scholar] [CrossRef]
|
|
[21]
|
Lopaschuk, G.D. and Jaswal, J.S. (2010) Energy Metabolic Phenotype of the Cardiomyocyte during Development, Differentiation, and Postnatal Maturation. Journal of Cardiovascular Pharmacology, 56, 130-140. [Google Scholar] [CrossRef]
|
|
[22]
|
Han, J.K., Lee, H.S., Yang, H.M., et al. (2008) Peroxisome Proliferator-Activated Receptor-Delta Agonist Enhances Vasculogenesis by Regulating Endothelial Progenitor Cells through Genomic and Nongenomic Activations of the Phosphatidylinositol 3-Kinase/Akt Pathway. Circulation, 118, 1021-1033. [Google Scholar] [CrossRef]
|
|
[23]
|
Scholtysek, C., Katzenbeisser, J., Fu, H., et al. (2013) PPARβ/Delta Governs Wnt Signaling and Bone Turnover. Nature Medicine, 19, 608-613. [Google Scholar] [CrossRef] [PubMed]
|
|
[24]
|
Wagner, N., Jehl-Pietri, C., Lopez, P., et al. (2009) Peroxisome Proliferator-Activated Receptor β Stimulation Induces Rapid Cardiac Growth and Angiogenesis via Direct Activation of Calcineurin. Cardiovascular Research, 83, 61-71. [Google Scholar] [CrossRef] [PubMed]
|
|
[25]
|
Maccallini, C., Mollica, A. and Amoroso, R. (2017) The Positive Regulation of ENOS Signaling by PPAR Agonists in Cardiovascular Diseases. American Journal of Cardiovascular Drugs, 17, 273-281. [Google Scholar] [CrossRef] [PubMed]
|
|
[26]
|
Tang, W., Zeve, D., Suh, J.M., et al. (2008) White Fat Progenitor Cells Reside in the Adipose Vasculature. Science, 322, 583-586. [Google Scholar] [CrossRef] [PubMed]
|
|
[27]
|
Tomaru, T., Steger, D.J., Lefterova, M.I., et al. (2009) Adipocyte-Specific Expression of Murine Resistin Is Mediated by Synergism between Peroxisome Proliferator-Activated Receptor γ and CCAAT/Enhancer-Binding Proteins. Journal of Biological Chemistry, 284, 6116-6125. [Google Scholar] [CrossRef]
|
|
[28]
|
Moore, K.J., Rosen, E.D., Fitzgerald, M.L., et al. (2001) The Role of PPAR-γ in Macrophage Differentiation and Cholesterol Uptake. Nature Medicine, 7, 41-47. [Google Scholar] [CrossRef] [PubMed]
|
|
[29]
|
Bouhlel, M.A., Derudas, B., Rigamonti, E., et al. (2007) PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-Inflammatory Properties. Cell Metabolism, 6, 137-143. [Google Scholar] [CrossRef] [PubMed]
|
|
[30]
|
Cipolletta, D., Feuerer, M., Li, A., et al. (2012) PPAR-γ Is a Major Driver of the Accumulation and Phenotype of Adipose Tissue Treg Cells. Nature, 486, 549-553. [Google Scholar] [CrossRef] [PubMed]
|
|
[31]
|
Szatmari, I., Rajnavolgyi, E. and Nagy, L. (2006) PPARγ, a Lipid-Activated Transcription Factor as a Regulator of Dendritic Cell Function. Annals of the New York Academy of Sciences, 1088, 207-218. [Google Scholar] [CrossRef] [PubMed]
|
|
[32]
|
Sarraf, P., Mueller, E., Jones, D., et al. (1998) Differentiation and Reversal of Malignant Changes in Colon Cancer through PPARγ. Nature Medicine, 4, 1046-1052. [Google Scholar] [CrossRef] [PubMed]
|
|
[33]
|
Bren-Mattison, Y., Van Putten, V., Chan, D., et al. (2005) Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Inhibits Tumorigenesis by Reversing the Undifferentiated Phenotype of Metastatic Non-Small-Cell Lung Cancer Cells (NSCLC). Oncogene, 24, 1412-1422. [Google Scholar] [CrossRef] [PubMed]
|
|
[34]
|
Bonofiglio, D., Cione, E., Qi, H., et al. (2009) Combined Low Doses of PPARγ and RXR Ligands Trigger an Intrinsic Apoptotic Pathway in Human Breast Cancer Cells. The American Journal of Pathology, 175, 1270-1280. [Google Scholar] [CrossRef] [PubMed]
|
|
[35]
|
Westergaard, M., Henningsen, J., Svendsen, M.L., et al. (2001) Modulation of Keratinocyte Gene Expression and Differentiation by PPAR-Selective Ligands and Tetradecylthioacetic Acid. Journal of Investigative Dermatology, 116, 702-712. [Google Scholar] [CrossRef] [PubMed]
|
|
[36]
|
Rivier, M., Safonova, I., Lebrun, P., et al. (1998) Differential Expression of Peroxisome Proliferator-Activated Receptor Subtypes during the Differentiation of Human Keratinocytes. Journal of Investigative Dermatology, 111, 1116-1121. [Google Scholar] [CrossRef] [PubMed]
|
|
[37]
|
Mao-Qiang, M., Fowler, A.J., Schmuth, M., et al. (2004) Peroxisome-Proliferator-Activated Receptor (PPAR)-γ Activation Stimulates Keratinocyte Differentiation. Journal of Investigative Dermatology, 123, 305-312. [Google Scholar] [CrossRef]
|
|
[38]
|
Schmuth, M., Haqq, C.M., Cairns, W.J., et al. (2004) Peroxisome Proliferator-Activated Receptor (PPAR)-β/Delta Stimulates Differentiation and Lipid Accumulation in Keratinocytes. Journal of Investigative Dermatology, 122, 971-983. [Google Scholar] [CrossRef]
|
|
[39]
|
Xiao, Y., Wang, H., Wang, C., et al. (2020) MiR-203 Promotes HaCaT Cell Overproliferation through Targeting LXR-α and PPAR-γ. Cell Cycle, 19, 1928-1940. [Google Scholar] [CrossRef] [PubMed]
|
|
[40]
|
Rivier, M., Castiel, I., Safonova, I., et al. (2000) Peroxisome Proliferator-Activated Receptor-α Enhances Lipid Metabolism in a Skin Equivalent Model. Journal of Investigative Dermatology, 114, 681-687. [Google Scholar] [CrossRef] [PubMed]
|
|
[41]
|
Batheja, P., Song, Y., Wertz, P. and Michniak-Kohn, B. (2009) Effects of Growth Conditions On the Barrier Properties of a Human Skin Equivalent. Pharmaceutical Research, 26, 1689-1700. [Google Scholar] [CrossRef] [PubMed]
|
|
[42]
|
Jiang, Y.J., Uchida, Y., Lu, B., et al. (2009) Ceramide Stimulates ABCA12 Expression via Peroxisome Proliferator-Activated Receptor Delta in Human Keratinocytes. Journal of Biological Chemistry, 284, 18942-18952. [Google Scholar] [CrossRef]
|
|
[43]
|
Jiang, Y.J., Lu, B., Kim, P., et al. (2008) PPAR and LXR Activators Regulate ABCA12 Expression in Human Keratinocytes. Journal of Investigative Dermatology, 128, 104-109. [Google Scholar] [CrossRef] [PubMed]
|
|
[44]
|
Capolupo, L., Khven, I., Lederer, A.R., et al. (2022) Sphingolipids Control Dermal Fibroblast Heterogeneity. Science, 376, eabh1623. [Google Scholar] [CrossRef] [PubMed]
|
|
[45]
|
Zhao, X., Psarianos, P., Ghoraie, L.S., et al. (2019) Metabolic Regulation of Dermal Fibroblasts Contributes to Skin Extracellular Matrix Homeostasis and Fibrosis. Nature Metabolism, 1, 147-157. [Google Scholar] [CrossRef] [PubMed]
|
|
[46]
|
Majewski, G.P., Singh, S. and Bojanowski, K. (2021) Olive Leaf-Derived PPAR Agonist Complex Induces Collagen IV Synthesis in Human Skin Models. International Journal of Cosmetic Science, 43, 662-676. [Google Scholar] [CrossRef] [PubMed]
|
|
[47]
|
Kim, S.H., Nam, G.W., Lee, H.K., et al. (2006) The Effects of Musk T on Peroxisome Proliferator-Activated Receptor [PPAR]-α Activation, Epidermal Skin Homeostasis and Dermal Hyaluronic Acid Synthesis. Archives of Dermatological Research, 298, 273-282. [Google Scholar] [CrossRef] [PubMed]
|
|
[48]
|
Sng, M.K., Chan, J.S.K., Teo, Z., et al. (2018) Selective Deletion of PPARβ/Delta in Fibroblasts Causes Dermal Fibrosis by Attenuated LRG1 Expression. Cell Discovery, 4, Article No. 15. [Google Scholar] [CrossRef] [PubMed]
|
|
[49]
|
Jung, Y.R., Lee, E.K., Kim, D.H., et al. (2015) Upregulation of Collagen Expression via PPARβ/Delta Activation in Aged Skin by Magnesium Lithospermate B from Salvia Miltiorrhiza. Journal of Natural Products, 78, 2110-2115. [Google Scholar] [CrossRef] [PubMed]
|
|
[50]
|
Dozsa, A., Mihaly, J., Dezso, B., et al. (2016) Decreased Peroxisome Proliferator-Activated Receptor γ Level and Signalling in Sebaceous Glands of Patients with Acne Vulgaris. Clinical and Experimental Dermatology, 41, 547-551. [Google Scholar] [CrossRef] [PubMed]
|
|
[51]
|
Dozsa, A., Dezso, B., Toth, B.I., et al. (2014) PPARγ-Mediated and Arachidonic Acid-Dependent Signaling Is Involved in Differentiation and Lipid Production of Human Sebocytes. Journal of Investigative Dermatology, 134, 910-920. [Google Scholar] [CrossRef] [PubMed]
|
|
[52]
|
Trivedi, N.R., Cong, Z., Nelson, A.M., et al. (2006) Peroxisome Proliferator-Activated Receptors Increase Human Sebum Production. Journal of Investigative Dermatology, 126, 2002-2009. [Google Scholar] [CrossRef] [PubMed]
|
|
[53]
|
Konger, R.L., Derr-Yellin, E., Zimmers, T.A., et al. (2021) Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin. International Journal of Molecular Sciences, 22, Article 8634. [Google Scholar] [CrossRef] [PubMed]
|
|
[54]
|
Kovacs, D., Lovaszi, M., Poliska, S., et al. (2016) Sebocytes Differentially Express and Secrete Adipokines. Experimental Dermatology, 25, 194-199. [Google Scholar] [CrossRef] [PubMed]
|
|
[55]
|
Zouboulis, C.C. (2020) Endocrinology and Immunology of Acne: Two Sides of the Same Coin. Experimental Dermatology, 29, 840-859. [Google Scholar] [CrossRef] [PubMed]
|
|
[56]
|
Bharti, S. and Vadlamudi, H.C. (2021) A Strategic Review on the Involvement of Receptors, Transcription Factors and Hormones in Acne Pathogenesis. Journal of Receptors and Signal Transduction, 41, 105-116. [Google Scholar] [CrossRef] [PubMed]
|
|
[57]
|
Lin, J.Y. and Fisher, D.E. (2007) Melanocyte Biology and Skin Pigmentation. Nature, 445, 843-850. [Google Scholar] [CrossRef] [PubMed]
|
|
[58]
|
Kang, H.Y., Chung, E., Lee, M., et al. (2004) Expression and Function of Peroxisome Proliferator-Activated Receptors in Human Melanocytes. British Journal of Dermatology, 150, 462-468. [Google Scholar] [CrossRef] [PubMed]
|
|
[59]
|
Zhao, S., Chen, X., Dutta, K., et al. (2023) Multiple Gene-Drug Prediction Tool Reveals Rosiglitazone Based Treatment Pathway for Non-Segmental Vitiligo. Inflammation. [Google Scholar] [CrossRef] [PubMed]
|
|
[60]
|
Lee, J.S., Choi, Y.M. and Kang, H.Y. (2007) PPAR-γ Agonist, Ciglitazone, Increases Pigmentation and Migration of Human Melanocytes. Experimental Dermatology, 16, 118-123. [Google Scholar] [CrossRef] [PubMed]
|
|
[61]
|
Maresca, V., Flori, E., Camera, E., et al. (2013) Linking αMSH with PPARγ in B16-F10 Melanoma. Pigment Cell & Melanoma Research, 26, 113-127. [Google Scholar] [CrossRef]
|
|
[62]
|
Shoag, J., Haq, R., Zhang, M., et al. (2013) PGC-1 Coactivators Regulate MITF and the Tanning Response. Molecular Cell, 49, 145-157. [Google Scholar] [CrossRef] [PubMed]
|
|
[63]
|
Herraiz, C., Martinez-Vicente, I. and Maresca, V. (2021) The α-Melanocyte-Stimulating Hormone/Melanocortin-1 Receptor Interaction: A Driver of Pleiotropic Effects Beyond Pigmentation. Pigment Cell & Melanoma Research, 34, 748-761. [Google Scholar] [CrossRef] [PubMed]
|
|
[64]
|
Ramot, Y., Alam, M., Olah, A., et al. (2018) Peroxisome Proliferator-Activated Receptor-γ-Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium. Journal of Investigative Dermatology, 138, 1656-1659. [Google Scholar] [CrossRef] [PubMed]
|
|
[65]
|
Ramot, Y., Mastrofrancesco, A., Herczeg-Lisztes, E., et al. (2014) Advanced Inhibition of Undesired Human Hair Growth by PPAγ Modulation? Journal of Investigative Dermatology, 134, 1128-1131. [Google Scholar] [CrossRef] [PubMed]
|
|
[66]
|
Imanishi, H., Ansell, D.M., Cheret, J.,et al. (2018) Epithelial-To-Mesenchymal Stem Cell Transition in a Human Organ: Lessons from Lichen Planopilaris. Journal of Investigative Dermatology, 138, 511-519. [Google Scholar] [CrossRef] [PubMed]
|
|
[67]
|
Billoni, N., Buan, B., Gautier, B., et al. (2000) Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPAR α Involvement in Hair Growth. Acta Dermato-Venereologica, 80, 329-334. [Google Scholar] [CrossRef] [PubMed]
|
|
[68]
|
Huang, C.F., Chang, Y.J., Hsueh, Y.Y., et al. (2016) Assembling Composite Dermal Papilla Spheres with Adipose-Derived Stem Cells to Enhance Hair Follicle Induction. Scientific Reports, 6, Article No. 26436. [Google Scholar] [CrossRef] [PubMed]
|
|
[69]
|
Tan, N.S., Icre, G., Montagner, A., et al. (2007) The Nuclear Hormone Receptor Peroxisome Proliferator-Activated Receptor β/Delta Potentiates Cell Chemotactism, Polarization, and Migration. Molecular and Cellular Biology, 27, 7161-7175. [Google Scholar] [CrossRef]
|
|
[70]
|
Di-Poi, N., Ng, C.Y., Tan, N.S., et al. (2005) Epithelium-Mesenchyme Interactions Control the Activity of Peroxisome Proliferator-Activated Receptor β/Delta during Hair Follicle Development. Molecular and Cellular Biology, 25, 1696-1712. [Google Scholar] [CrossRef]
|