基本情况
谢平，中国科学院物理研究所，软物质物理实验室，研究员、博士生导师。
研究领域
生物物理。1991年至2003年从事非线性光学（包括光折变非线性光学、非线性时空动力学及非线性光子晶体）的研究，从2003年起从事生物物理研究。
教育背景
1991年至1994年 博士，中科院物理所
1988年至1991年 硕士，北京理工大学
1980年至1984年 学士，北京理工大学
目前的研究课题及展望
研究各种生物马达蛋白（例如：kinesin,
myosin, dynein, Fo-F1 ATPase等）和核酸酶（例如：DNA helicase, DNA
polymerase, RNA polymerase, viral reverse transcriptase, telomerase, ribosome,
topoisomerase等）的运动和工作机理。拟开展衰老的分子机理研究及如何延缓衰老研究。
论文发表
1.
Shi X.-X., Liu Y.-R., Xie P. (2025) Transport of
track-interacted cargo by molecular motor. Commun. Theor. Phys. 77 (2025)
095601.
2.
Shi X., Wang Y., Liu
Y., Xie P. (2025) On load dependence
of detachment rate of kinesin motor. Chin. Phys. B 34, 018702.
3.
Shi X.-X., Liu Y.-R., Xie P. (2025) Factors determining
kinesin motor in a predominant one-head-bound or two-heads-bound state during
its stepping cycle. Biomolecules 15, 717.
4. Xie
P. (2025) Modeling
study of effects of tubulin carboxy-terminal tails on dynamics of kinesin and
dynein motors. Protein J. https://doi.org/10.1007/s10930-025-10267-8
5. Xie P. (2025) A
model of tubulin removal and exchange caused by kinesin motor walking on
microtubule lattices. J. Theor. Biol. 605,
112088.
6. Xie
P. (2025) Effects of stalk orientation
and size of trapped bead on force–velocity relation of kinesin motor determined
using single molecule optical trapping methods. J. Biol. Phys. 51, 7.
7. Xie
P. (2025) Modeling Studies of Microtubule
Polymerization Promoted by Kinesin‐5 Motors. Applied Research 4, e70017.
8. Xie
P. (2025) The effect of tau on dynamics of
kinesin motor. Innov. Discov. 2,
6.
9. Xie
P. (2025) Mechanochemical coupling of two
coupled kinesin monomers: comparison with that of the single dimer. RSC
Mechanochem. 2, 127–141.
10. Xie P. (2024) Modeling of Chemomechanical
Coupling of Cytoplasmic Dynein Motors. J. Phys. Chem. B 128, 10063−10074
11. Xie P. (2024). Modeling study of kinesin-13 MCAK microtubule depolymerase. Euro.
Biophys. J. 53, 339–354.
12. Xie P. (2024) A
model of microtubule depolymerization by kinesin-8 motor proteins. Adv.
Protein Chem. Struct. Biol. 141, 87-122.
13. Xie P. (2024) Modeling
Studies of the Mechanism of Context-Dependent Bidirectional Movements of
Kinesin-14 Motors. Molecules 2024, 29,1792.
14. Xie P. (2024) ATP-concentration-dependent fractions of one-head-bound and
two-heads-bound states of kinesin motor during its chemomechanical coupling
cycle. J. Phys. Chem. Lett. 15, 3893−3899.
15. Xie P. (2024) A model for cooperativity of kinesin-4 motors by communicating through
the microtubule track. Chem. Phys. 581, 112274.
16. Xie P. (2024) A
model for chemomechanical coupling of kinesin‑3 motor. Cell. Mol. Bioeng. 17, 137–151.
17. Xie P. (2024) Effect of small molecular crowders on dynamics of kinesin
molecular motors. J. Theor. Biol. 578,
111685.
18. Xie P. (2023) Molecular mechanism of interaction between kinesin motors affecting
their residence times on microtubule lattice and end. J. Theor. Biol. 571,
111556.
19. Xie P. (2023)
Determinant
factors for residence time of kinesin motors at microtubule ends. J. Biol.
Phys. 49,
77–93.
20. Xie P. (2023)
Effect of the neck linker on processive stepping of kinesin motor. Biophysica
3, 46–68.
21. Xie P. (2023) A model for the
catalytic activity of microtubule polymerases. Cytoskeleton 80, 7–20.
22. Xie P.* (2022) Modeling Study of the Dynamics of Kinesin-14 Molecular
Motors. J. Phys. Chem. B 126, 8720−8734
23. Xie P.* (2022) Effect of varying
load in moving period of a step on dynamics of molecular motors. Eur. Phys. J. E 45 28
24. Wang
Y.,
Liu Y.-R.,
Wang P.-Y.; Xie P.* (2022)
Dynamics of cooperative transport by multiple kinesin motors and diffusing
microtubule-associated proteins. Commun. Theor. Phys. 74, 105601.
25. Wang J.-G., Shi X.-X, Liu Y.-R.,
Wang P.-Y., Chen H.,
Xie P.* (2022) Investigation of the structural and
dynamic basis of kinesin dissociation from microtubule by atomistic molecular
dynamics simulations. Chin. Phys. B 31, 058702.