基本情况

周宇涵，博士，大连理工大学制药科学与技术学院教授。

研究领域

有机合成、金属有机化学等

教育背景

2009年 博士后，法国巴黎第五大学药学院

2003年 博士，大连理工大学化工学院

发表论文

1. Bangzhong Wang, Luyang Sun, Pengyue Zhang, Shuaibo Zhang, Jinfeng Zhao, Jingping Qu, Yuhan Zhou. Synthesis of chiral 2-trifluoromethyl-4-(tetrahydroquinolinyl)-4H-chromenes via Pd-catalyzed asymmetric amination. Adv. Synth. Catal. 2025, 367, e202401422.

2. Bangzhong Wang, Luyang Sun, Pengyue Zhang, Shuaibo Zhang, Jinfeng Zhao, Jingping Qu, Yuhan Zhou. Pd-Catalyzed asymmetric synthesis of chiral 2-trifluoromethyl-4-(indol-3-yl)-4H-chromene derivatives. J. Org. Chem. 2025, 90, 5, 1755-1767.

3. Nan Cai, Xiang Gao, Ling Jia, Yunzhe Liu, Jinfeng Zhao, Jingping Qu, Yuhan Zhou. 2-Trifluoromethyl-2H-chromene ethers: The dual triumph of anti-inflammation and analgesia with minimal ulcer threat. Bioorg. Chem. 2025, 154, 108050(1-18).

4. Nan Cai, Xiang Gao, Li Yang, Wuding Sun, Shuaibo Zhang, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Discovery of novel NSAID hybrids as cPLA2/COX-2 dual inhibitors alleviating rheumatoid arthritis via inhibiting p38 MAPK pathway. Eur. J. Med. Chem. 2024, 267, 116176(1-21).

5. Nan Cai, Xiang Gao, Ling Jia, Yunzhe Liu, Lingwei Zhou, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* 3-(2-Triffuoromethyl-3-aryl-4H-chromen-4-yl)-1H-indoles: Mastering anti-inffammation and analgesia while mitigating gastrointestinal side effects. Bioorg. Chem. 2024, 153, 107805(1-17).

6. Nan Cai, Xiang Gao, Wenjin Li, Li Yang, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Novel trifluoromethyl ketone derivatives as oral cPLA2/COX-2 dual inhibitors for resolution of inflammation in rheumatoid arthritis. Bioorg. Chem. 2024, 148, 107453(1-20).

7. Shuaibo Zhang, Dong Li, Bangzhong Wang, Wuding Sun, Haojun Ma, Kai Di, Luyang Sun, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Palladium-catalyzed asymmetric trifluoromethylated allylic alkylation of N-substituted glycine ethyl esters with α-(trifluoromethyl)alkenyl acetates. Eur. J. Org. Chem. 2023, 26, e202300593 (1-5).

8. Xuejian Li, Bangzhong Wang, Dong Li, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* KI-Mediated chlorine gas-free synthesis of 3,3-dichloro-2-oxindole derivatives. Eur. J. Org. Chem. 2023, 26, e202201452 (1-7).

9. Dong Li, Shuaibo Zhang, Bangzhong Wang,Wuding Sun, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Palladium-catalyzed stereoselective trifluoromethylated allylic alkylation of 3-substituted oxindoles. Org. Chem. Front. 2022, 9(3), 810-815.

10. Dong Li, Wande Zhang, Shuaibo Zhang, Wuding Sun, Jinfeng Zhao, Baomin Wang, Jingping Qu, Yuhan Zhou.* Palladium-catalyzed asymmetric trifluoromethylated allylic alkylation of pyrazolones enabled by α-(trifluoromethyl)alkenyl acetates. Org. Lett. 2021, 23(15), 5804-5808.