基本情况

古练权，药物化学、有机化学和化学生物学教授（二级），现为中山大学药学院药物化学研究所所长。


研究领域

药物化学、有机化学和化学生物学


工作经历

1993年 博士生导师，中山大学化学系

1992年 教授，中山大学化学系


论文发表

近年来，在国内外重要刊物发表论文200多篇，获得专利15项（包括国内外专利），发表著作4部

  1. Isaindigotone Derivatives: A New Class of Highly Selective Ligands for Telomeric G-quadruplex DNA, J.Med.Chem., 2009, 52, 2825-2835
  2. 5-N-Methylated Quindoline Derivatives as Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-N Positive Charge on Quadruplex Binding Affinity and Cell Proliferation, J.Med.Chem.2008, 51, 6381- 6392
  3. Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives, J.Med.Chem.2007, 50, 1465-1474
  4. Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase, J. Med. Chem. 2005, 48, 7315
  5. Senesence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines. Oncogene, 2006, 25, 503
  6. Inhibition of myc promoter and telomerase activity and induction of delayed apoptosis by SYUIQ-5, a novel G-quadruplex interactive agent in leukemia cells, Leukemia, 2007, 1-3
  7. G-quadruplexes: a target for anti-cancer drug design, ChemMedChem,2008, 3, 690-713
  8. Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors, Bioorg.Med.Chem., 2008, 16, 8035-8041
  9. Synthesis,cytotoxic activities and structure-activity relationships of topoisomerase I inhibitors: Indolizinoquinoline-5, 12-dione derivatives, Bioorg. Med.Chem.2008, 16, 4617-4325
  10. 9-N-Substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc, Bioorg.Med.Chem., 2008, 16, 7582-7591
  11. 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA, Bioorg.Med.Chem. 2007, 15, 5493-5501
  12. Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands, Bioorg.Med.Chem.Lett, 2009, 19, 3414-3417
  13. Synthesis and antimultidrug resistance evaluation of icariin and its derivatives, Bioorg.Med.Chem.Lett, 2009, 19, 4237-4240
  14. Inhibition of thioredoxin reductase by curcumin analogs, Biosci. Biotech. Biochem., 2008, 72, 2214-2218
  15. Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors, Bioorg.Med.Chem., 2008, 16, 3790-3793
  16. A Facile Synthesis of Novel Heteropolycyclic Pyrazines and Oxazoles Mechanistic Studies of 2, 3-Dihydrobenzo[de]chromene-7, 8-dione with Amines, Heterocycles, 2008, 75, 1773-1778
  17. Oxoisoaporphine Alkaloid Derivatives: Synthesis, DNA Binding Affinity and Cytotoxicity, Eur.J.Med.Chem., 2008, 43, 973-980
  18. Synergetic inhibition of metal ions and genistein on a-glucosidase, FEBS Letters, 2004, 576, 46-50
  19. Derivatives of oxoisoaporphine alkaloids: A novel class of selective acetycholinesterase inhibitors, Bioorg. Med. Chem. Lett. 2007, 17, 3765-3768
  20. Oxoisoaporphine alkaloid derivatives:synthesis, DNA bimding affinity and cytotoxicity, Eur.J. Med. Chem, 2007, 42, in Press, corrected Proof, Available online
  21. Apoptosis-inducing activity of new pyrazole emodin derivatives in Human Hepatocellular Carcinoma HepG2 cells,Biol.Pharm.Bull. 2007, 30, 1113-1116
  22. 《生物有机化学》（第一作者），高等教育出版社和施普林格出版社，1998。科技图书股份有限公司（台湾，繁体字版），2001
  23. 《生物化学》（第一作者），高等教育出版社，2000
  24. 《有机化学》（第一作者），高等教育出版社，2008
  25. 《化学生物学》（第二作者），化工出版社，2006