基本情况
高钟镐,博士,中国医学科学院北京协和医学院药物研究研究员。2001年加入美国Vladimir P Torchilin教授实验组从事博士后研究,主要研究方向为药物控释和靶向制剂的研究。2003年到2008年被聘为犹他大学助教授,主要从事肿瘤靶向纳米制剂和超声微泡靶向给药系统研究。
研究领域
生物物理药剂学、药物控释和靶向制剂的研究、肿瘤靶向纳米制剂和超声微泡靶向给药系统研究、分子药剂学研究
论文发表
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Wei Huang,
Ming Lv, Zhonggao Gao,Polyethylenimine grafted
with diblock copolymers of polyethylene glycol and polycaprolactone as siRNA
delivery vector.J Control Release. 2011, 152, 143-145 (7.16)
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陈卫,金明姬,高钟镐,王丽萍,朴海峰,pH 敏感性的TAT肽修饰胶束的制备及其体外评价,药学学报,2011,46(5):599-604
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杨飞飞,黄伟,李云飞,高钟镐,siRNA非病毒递送载体的研究现状,药学学报,2011,46(12):1436-1443
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Zhong-Gao Gao, Li Tian, Jun Hu,
In-Suh Park, You Han Bae, Prevention of Metastasis in a 4T1 Murine Breast
Cancer Model byDoxorubicin Carried by Folate Conjugated pH Sensitive Polymeric
Micelles, J Control Release. 2011, 152, 84-9. (7.16)
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Natalya Rapoport, Kweon-Ho Nam, Roohi
Gupta, Zhongao Gao, Praveena Mohan, Allison Payne, Nick Todd , Xin Liu ,
Taeho Kim, Jill Shea, Courtney Scaife, Dennis L. Parker, Eun-Kee Jeong,
Anne M. Kennedy, Ultrasound-mediated tumor imaging and nanotherapy using drug
loaded, block copolymer stabilized perfluorocarbon nanoemulsions. J
Control Release. 2011, 153(1): 4-15
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黄伟,邓亮生,高钟镐,王玉丽等,人胰岛素样生长因子-I基因P1启动子区域CA微卫星多态性对启动子活性的影响,解放军医学杂志,2010,35(9):1113-1116
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黄伟,崔光华,王玉丽,贺俊峰,周旭,高钟镐,PicoGreen荧光法结合茚三酮比色法测定载pDNA壳聚糖纳米粒中pDNA的包封率和载药量,药物分析杂志,2010,30(2):226-229
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黄伟,吕明,李保卫,邵荣光,高钟镐。大鼠脑胶质瘤荧光素酶动物模型建模细胞株C6-Luc的构建,解放军医学杂志,2011,36(1):35-38
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Wei Huang, Ming
Lv, Zhong
Gao Gao, Synthesis of polyethylenimine grafted
with copolymers of polyethylene glycol and polycaprolactone and its
potential for siRNA delivery, Chinese Chemical
Letters. 2011, 22(6): 749-752
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黄伟,吕明,高钟镐,金明姬,杨长青。mPEG-PCL-g-PEI聚合物纳米粒介导的小干扰RNA递送。药学学报2011,46(3):344-349
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吕明,黄伟,高钟镐。聚乙烯亚胺及其衍生物介导siRNA递送的研究进展。中国药学杂志,2011,46(2)81-84
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Dong-Han Han, Zhe-Hu Jin, Yan-Zhe
Jin, Xue-zhe Yin,Yuan-Yuan Shen,and Zhong-Gao Gao.Thermal Reversible
Microemulsion System for Poorly WaterSoluble YH439 for Oral Delivery.Chem.Pharm.Bull.,2010,58(1),11-15. (1.623)
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Gao, Zhong-Gao, Jin, Zhe-Hu,
Yin, Xue-Zhe, Tian, Li. Multifunctional Nanparticles for Targeting Cancer
Therapy. J NANOSCI NANOTECHNO, 2010, 10 (11), 7743-6
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D. Kim, Z.G. Gao, E.S. Lee, Y.H.
Bae. In vivo evaluation of doxorubicin-loaded polymeric micelles targeting
folate receptors and early endosomal pH in drug-resistant ovarian cancer, Mol.
Pharmaceutics. 2009, 6(5): 1353-62
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N. Rapoport, K.H. Nam, Z. Gao, and A.
Kennedy. Application of Ultrasound for Targeted Nanotherapy of Malignant
Tumors. Acoustical Physics, 2009, 55: 594-601
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沈圆圆,高钟镐,超声微泡作为基因或药物载体的研究进展,药学学报,2009,44(9): 961-966
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全毅,赵春植,韩东汉,高钟镐,药物透过血脑屏障靶向传递系统的研究,国际神经病学神经外科学杂志,2009,36(5):466-473
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全毅,黄伟,邵荣光,韩东汉,高钟镐,C6/Wistar大鼠脑胶质瘤模型的建立与评估,中华神经外科杂志(已录用)
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全美燕,全毅,韩东汉,吕明,高钟镐,C6-Luc大鼠胶质瘤细胞株成瘤实验的研究,吉林大学学报医学版(已录用)
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Eun Seong Leea, 1, Zhonggao
Gaoa, Dongin Kima, Kyeongsoon Parkb, Ick Chan Kwonb and You Han
Bae 2008, Super pH-sensitive multifunctional polymeric micelle for tumor
pH(e) specific TAT exposure and multidrug resistance. J Control Release 2008, 129(3): 228-236