基本情况
周宇涵,博士,大连理工大学,制药科学与技术学院,教授,博士生导师。
研究领域
药物合成化学等
教育经历
2009年2月至2010年1月 博士后,法国巴黎第五大学药学院
2000年3月至2003年2月 博士,大连理工大学精细化工系
1997年9月至2000年3月 硕士,大连理工大学精细化工系
1993年9月至1997年7月 学士,大连理工大学精细化工系
论文发表
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Yilong Zhao, Yuhan Zhou,* Chunxia Zhang, Dong Li, Puhua Sun, Jianzhe
Li, Huan Wang, Jianhui Liu, Jingping Qu. Base-controlled regiodivergent
azidation of trifluoromethyl alkenyl triflates: transition-metal-free Access to
CF3-containing allyl azides and alkenyl azides. J. Org. Chem. 2018, 83(5),
2858-2868
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Yuhan Zhou,* Chunxia Zhang, Yilong Zhao, Dong Li, Jinfeng Zhao,
Zhaotian Wang, Jingping Qu. Base-promoted double-bond-migration/hydrolysis/isomerization
of 4-aryl-1,1,1-trifluorobut-2-en-2-yl trifluoromethanesulfonates: a metal-free
approach to β-trifluoromethyl ketones. Eur. J. Org. Chem. 2018, 6217-6222
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Dong Li, Yuhan Zhou,* Yilong Zhao, Chunxia Zhang, Jianzhe Li,
Jinfeng Zhao, Jingping Qu. Synthesis of 2-trifluoromethyl-2-hydroxy-2H-chromenes
via cyclization of (Z)-trifluoromethyl alkenyl triflates and salicylaldehydes. J.
Fluorine Chem. 2018, 212, 122-129
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Yuhan Zhou,* Huan Wang, Yang Liu, Yilong Zhao, Chunxia Zhang,
Jingping Qu. Iron-catalyzed boration of allylic alcohols with H3BO3 as an
additive. Synth. Commun. 2018, 48(7), 795-801
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Yang Liu, Yuhan Zhou,* Yilong Zhao, Jingping Qu. Synthesis of
gem-difluoroallylboronates via FeCl2-catalyzed boration/β-fluorine elimination
of trifluoromethyl alkenes. Org. Lett. 2017, 19(4), 946-949
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Yuhan Zhou,* Huan Wang, Yang Liu, Yilong Zhao, Chunxia Zhang and
Jingping Qu. Iron-catalyzed boration of allylic esters: an efficient approach
to allylic boronates. Org. Chem. Front. 2017, 4(8), 1580 - 1585
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Yilong Zhao, Yuhan Zhou,* Chunxia Zhang, Huan Wang, Jinfeng Zhao,
Kun Jin, Jihong Liu, Jianhui Liu, Jingping Qu. Palladium-catalyzed
geometrically selective hydrogenation of (Z)-trifluoromethyl alkenyl triflate: an
efficient approach to (Z) or (E)-3,3,3-trifluoropropenyl derivatives. Org.
Biomol. Chem. 2017, 15(27), 5693-5700. (Inside front cover, 2017 Hot Articles)
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Yuhan Zhou,* Ling Li, Xiaoliang Dong, Yixin Zhang, Dawei Yang, Yang
Liu, Jingping Qu.* Synthesis of diiron sulfur clusters containing
thiolato-1,8-naphthalene imide ligand. Inorg. Chem. Commun. 2017, 80, 10-14
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Yuhan Zhou,* Changpeng Wu, Xiaoliang Dong, Jingping Qu. Synthesis of
6-trichloromethylphenanthridines by transition metal-free radical cyclization
of 2-isocyanobiphenyls. J. Org. Chem. 2016, 81(12), 5202-5208
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Yilong Zhao, Yuhan Zhou,* Juan Liu, Dongmei Yang, Liang Tao, Yang
Liu, Xiaoliang Dong, Jianhui Liu, Jingping Qu. Synthesis of (Z)-α-trifluoromethyl
alkenyl triflate: a scaffold for diverse trifluoromethylated species. J. Org.
Chem. 2016, 81(11), 4797-4806
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Yuhan Zhou,* Xiaoliang Dong, Yixin Zhang, Peng Tong, and Jingping
Qu*. Highly selective fluorescence sensors for the fluoride anion based on
carboxylate-bridged diiron complexes. Dalton Trans. 2016, 45, 6839-6846. (back
cover)
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Changpeng Wu, Yuhan Zhou,* Xiaoliang Dong, Jingping Qu. Synthesis of
6-(arylthio)phenanthridines by cyclization reaction of 2-isocyanobiphenyls with
thiols. ARKIVOC 2016, (iii), 110-124
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Yang Liu, Yuhan Zhou,* Huan Wang and Jingping Qu. FeCl2-catalyzed
hydroboration of aryl alkenes with bis(pinacolato)diboron. RSC Adv. 2015, 5,
73705-73713
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Xiaoliang Dong, Litao Liu, Yuhan Zhou,* Jun Liu, Yixin Zhang, Yanhui
Chen, and Jingping Qu.* Synthesis of carboxylate-bridged iron-thiolate clusters
from alcohols/aldehydes or carboxylate salts. Dalton Trans. 2015, 44,
14952-14958
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Xiaoliang Dong, Yuhan Zhou,* Yuming Song, Jingping Qu. Anthracene-Fe3+
ensemble based turn-on fluorescent probes for selective detection of fluoride. J.
Fluorine Chem. 2015, 178, 61-67
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Dongmei Yang, Yuhan Zhou,* Yuming Song, Jingping Qu. A practical
synthesis of trifluoromethyl alkyl ketones.J. Fluorine Chem. 2015, 173,
6-11
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Yuhan Zhou,* Yuming Song, Yang Liu, Jingping Qu. A convenient
one-pot preparation of spiro[fluorene-9,9’-xanthene]-3’,6’-diol derivatives. ARKIVOC
2015 (v), 99-109
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Weiguo Song, Liangjun Dong, Yuhan Zhou,* Yongqiang Fu, Wenfang Xu.
Catalytic asymmetric synthesis of esomeprazole by a titanium complex with a
hexaaza triphenolic macrocycle ligand. Synth. Commun., 2015, 45(1), 70-77
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Yuhan Zhou,* Dongmei Yang, Gen Luo, Yilong Zhao, Yi Luo,* Na Xue,
Jingping Qu. Highly selective trifluoroacetic ester/ketone metathesis: an
efficient approach to trifluoromethyl ketones and esters. Tetrahedron 2014, 70(31),
4668-4674
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Yuhan Zhou,* Guchao Gao, Yuming Song, Jingping Qu*. Enantioselective
reduction of prochiral ketones with NaBH4/Me2SO4/(S)-Me-CBS. Synth. Commun., 2014,
44(10), 1515-1520
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杨冬梅,周宇涵,* 常晴,赵一龙,曲景平. 三氟甲基烷基酮的生物活性及合成方法. 化学进展 2014, 26(6), 976-986
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Xiaoneng Cui, Jianzhang Zhao, Yuhan Zhou, Jie Ma, Yilong Zhao.
Reversible photoswitching of triplet-triplet annihilation upconversion using
dithienylethene photochromic switches. J. Am. Chem. Soc. 2014, 136, 9256-9259
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Dongmei Yang, Yuhan Zhou,* Na Xue, Jingping Qu.* Synthesis of
trifluoromethyl ketones via tandem claisen condensation and retro-claisen C−C
bond-cleavage reaction. J. Org. Chem. 2013, 78(8), 4171-4176. (“organic-chemistry.org”专题报道: J42-Y2013)
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Jinfeng Zhao, Lei Wang, Yuhan Zhou,* Yixin Zhang, Nan Zhang, Chunmei
Jia, Fengshuo Hu, Yanhui Chen, Baomin Wang, Jingping Qu.* Synthesis, structure
and reactions of triply selenolate-bridged diiron complex [Cp*Fe(µ-SeMe)3FeCp*].
Inorg. Chem. Commun. 2013, 29, 179-182
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Weiguo Song, Yuhan Zhou,* Yongqiang Fu, Wenfang Xu.
Self-disproportionation of enantiomers of prazoles via achiral, gravity-driven
silica gel column chromatography. Tetrahedron: Asymmetry 2013, 24(15-16),
909-912
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Yang Li, Ying Li, Baomin Wang, Yi Luo, Dawei Yang, Peng Tong,
Jinfeng Zhao, Lun Luo, Yuhan Zhou, Si Chen, Fang Cheng, Jingping Qu. Ammonia
formation by a thiolate-bridged diiron amide complex as a nitrogenase mimic.
Nature Chem. 2013, 5(4), 320-326
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Jinfeng Zhao, Lei Wang, Yuhan Zhou, Yixin Zhang, Nan Zhang, Yanhui
Chen, Jingping Qu. Synthesis and characterization of a thiolate-bridged diiron
complex with two monocoordinated azido ligands: [Cp*Fe(μ-SMe)N3]2 (Cp* = η5-C5Me5).
Chinese J. Struc. Chem. 2013, 32 (7), 1083-1087
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徐珊珊,周宇涵*,曲景平*. CuOTf/NNN三齿钳形配体催化不对称Henry反应. 有机化学, 2012, 32(7), 1131-1135
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Guowei Wang, Baomin Wang, Shuai Qi, Jinfeng Zhao, Yuhan Zhou,
Jingping Qu*. Highly enantio- and diastereoselective vinylogous aldol reaction
by LiCl-assisted BINOL―titanium species,Org. Lett. 2012, 14, 2734-2737
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董晓亮,周宇涵*,徐珊珊,曲景平*. 5-芳甲氧基苯基吡唑衍生物的合成及除草活性. 有机化学, 2011, 31(7), 1020-1026
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赵金凤,窦海建,周宇涵,曲景平. (S,S)-TsDPEN-Ru催化不对称氢转移还原β-胺基酮及在度洛西汀合成中的应用. 高等学校化学学报,2011, 32 (10), 2331-2334
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Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Direct synthesis of
1,4-disubstituted-5-alumino-1,2,3-triazoles by a copper-catalyzed cycloaddition
of organic azides and mixed-aluminum acetylides. Angew. Chem. Int. Ed. 2010, 49(14),
2607-2610 (Synfacts 2010, 6, 0704)
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Yuhan Zhou,* Na Xue, Guowei Wang, Jingping Qu. Synthesis, structure
and herbicidal activity of substituted phenyl pyrazole derivatives. J. Chem.
Res.2010, 34(12), 684-688
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Guowei Wang, Jinfeng Zhao, Yuhan Zhou, Baomin Wang, Jingping Qu.
Mild and highly enantioselective vinylogous aldol reaction of brassard’s diene
with aromatic aldehydes by combined Lewis acid catalyst. J. Org. Chem. 2010, 75(15),
5326-5329 (Synfacts
2010, 6, 1266)
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Yuhan Zhou,* Yanhui Chen, Weirong Miao, Jingping Qu. Synthesis,
structures and herbicidal activity of isoxazole derivatives. J. Heterocyclic
Chem. 2010, 47(6), 1310-1316
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Yinsong Tao, Yuhan Zhou, Jingping Qu, Masanobu Hidai. Highly
efficient and regioselective allylic amination of allylic alcohols catalyzed by
[Mo3PdS4] cluster. Tetrahedron Lett. 2010, 51, 1982-1984
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Na Xue, Yuhan Zhou,* Guowei Wang, Weirong Miao, Jingping Qu.*
Syntheses and herbicidal activity of pyrazolyl benzoxazole derivatives. J.
Heterocyclic Chem. 2010, 47(1): 15-21 (Top accessed papers from 2010)
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Pingping Chen, Yanhui Chen, Yuhan Zhou, Ying Peng, Jingping Qu,
Masanobu Hidai. Heterometallic cubane-type clusters [MMo3S4] (M = Au, Ag and
Cu): synthesis, structures and electrochemical properties. Dalton Trans. 2010, 39,
5658 – 5663
授权专利
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周宇涵,曲景平,杨冬梅,薛娜. 一种制备全氟烷基烷基酮化合物的方法. 专利号:201210411390.2,2015-2-25
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宋伟国,周宇涵,付永强,董良军,徐文方. 一种拉唑类化合物单一对映体的分离方法. 专利号:201310118349.0,2015-6-17
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宋伟国,付永强,孙晓明,董良军,高东圣,周宇涵,夏艳,王伟,吕伟香,田梅. 一种用于埃索美拉唑不对称合成的催化剂. 专利号:
201410286767.5, 2016.7.6
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周宇涵,曲景平,董晓亮. 一类以蒽为母体的双功能荧光探针、制备方法及应用. 专利号: 201510181059.X, 2016.12.7
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周宇涵,曲景平,柳阳,王欢.基于铁催化制备烷基硼酸酯化合物的方法.专利号:201510292951.5, 2017.6.27
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周宇涵,曲景平,董晓亮. 一类羧酸根桥联双核铁配合物荧光探针、制备方法及应用. 专利号: 201510561049.9, 2017.10.24
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周宇涵,曲景平,柳阳,赵一龙. 一种二氟烯丙基硼酸酯的制备方法及其应用. 专利号: 201610635012.0, 2018.3.13
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董良军,周宇涵,高东圣,王福洲,褚亚飞,吕伟香,李书涛,杨磊,宋伟国. 一种适用于工业化生产的右兰索拉唑的处理方法. 专利号:201510964214.5,2017.11.28
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周宇涵,曲景平,吴昌朋,董晓亮. 一类6-三氯甲基菲啶类化合物及其制备方法和应用. 专利号:ZL
201610294227.0,2018.7.13
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Yuhan Zhou, Jingping Qu, Xiaoliang Dong. Carboxylate-bridged binuclear
iron-sulfur clusters fluorescent probe preparation method and application
thereof. JP 2017-558380, 2018.12.14
专著
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Yuhan Zhou, Xiaoliang Dong, Jingping Qu. Synthesis, structure and
herbicidal activity of pyrazole derivatives. in Daiki Kobayashi and Eito
Watanabe Edit: Handbook on Herbicides: Biological Activity, Classification and
Health & Environmental Implications (Chapter 13) USA: Nova Science
Publishers, 2013, 263-276 (2013-12)
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Serge Mignani, Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Recent
Developments in the Synthesis 1,4,5-Trisubstituted Triazoles. Topics in
Heterocyclic Chemistry Vol. 28: Click Triazoles. (Edited by Janez Košmrlj.)
Springer-Verlag Berlin Heidelberg: 2012, 185-232
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李和平,周宇涵,冯光柱,申艳敏,黄雪,刘云,袁超,何利霞. 含氟溴碘精细化学品. 北京:化学工业出版社,2010-09-01.(“十一五国家重点图书”)
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李和平,冯光柱,魏文珑,孙建军,周宇涵,黄雪. 含氯精细化学品. 北京:化学工业出版社,2010-08-01. (“十一五国家重点图书”)