基本情况

邱声祥，药学博士，教授，博士生导师，中国科学院“百人计划”研究员，中国科学院华南植物园天然产物药物化学研究组首席研究员。中国科学院华南植物园&复大生物科技‘植物天然活性成分研究与应用’联合室主任。美国化学会(ACS)会员，美国质谱学会(ASMS)会员，美国生药学会(ASP)会员。中国科学院华南植物园学术委员会委员，国家自然科学基金评审专家，科技部国际科技合作计划评审专家，卫生部科技重大专项课题评审专家，广东省（广州市）自然科学基金评审专家。《中国中医药年鉴》（学术卷）特邀编委。

研究领域

植物天然产物的提取、分离、结构鉴定、活性天然产物分子作用机制及化学生物学、天然产物药物化学及新药发现、中草药和植物药及功能性植物产品的研究与开发、植物化学分类学与药用植物化学资源开发利用

教育背景

1998年 博士，Medicinal Chemistry & Pharmacognosy, University of Illinois, USA

1988年 硕士，中国科学院昆明植物研究所

1985年 学士，南昌(江西)大学

工作经历

2002年11月至2007年10月 Research Scientist, 美国 Washington University

2000年11月至2002年10月 Principal Scientist, 美国Watson制药公司

1998年9月至2000年10月   Senior Scientist, 美国Monsanto公司

1989年3月至1994年7月  助理研究员，中国医药研究开发中心

论文发表

1. S. X. Qiu. Natural products regain attention in oncology. Guest Editorial, Tropical Journal of Pharmaceutical Research, 2009, 8(5): 383-384
2. K. N. Prasad, J. Hao, J. Shi, T. Liu, J. Li, X. Y. Wei, S. X. Qiu, S. Xue, Y. M. Jiang. Antioxidant and anticancer activities of high pressure-assisted extract of longan (Dimocarpus longan Lour.) fruit pericarp. Innovative Food Science and Emerging Technologies, 2009, 10: 413-419
3. K. N. Prasad, H. H. Xie, J. Hao, B. Yang, S. X. Qiu, X. Y. Wei, F. Chen, Y. M. Jiang. Antioxidant and anticancer activities of 8-hydroxypsoralen isolated from wampee [Clausena lansium (Lour). Skeels] Peel. Food Chemistry, 2009, 118(1): 62-66
4. H. Y. Zhang, H. H. Xie, S. X. Qiu, J. H. Xue, X. Y. Wei. Heteroatom-containing antibacterial phenolic metabolites from a terrestrial Ampelomyces fungus. Bioscience Biotechnology and Biochemistr, 2008, 72(7): 1746-1749
5. Q. Gu, X. M. Zhang, J. Zhou, S. X. Qiu, J. J. Chen. One new dihydrobenzofuran lignan from Vitex trifolia. Journal of Asian Natural Products Research, 2008, 10(6): 499-502
6. S. X. Qiu, C. Dan, S. L. Peng, L. S. Ding, S. N. Chen, N. R. Farnsworth, M. L. Gross and P. Zhou. 25-Acetylcimigenol xylopyranoside, a triterpene glycoside from Black cohosh, inhibits osteoclastogenesis by modulating RANKL and TNF signaling pathways. Chemistry & Biology, 2007, 14, 860-869. 【Accompanying commentary‘Mending the bones with Natural Products’by G Sethi and Bharat Aggarwal, Chemistry & Biology, 2007, 14: 738-740.】
7. C. Dan, Y. Zhou, D. Ye, S. L. Peng, L. S. Ding, M. L. Gross, S. X. Qiu. Cimicifugadine from Cimicifuga foetida, a new class of triterpene alkaloids with novel reactivity. Organic Letters, 2007, 9(9): 1817-1816
8. L. R. Sun, X. M. Niu, C. Qin, Y. L. Zhang, S. Y. Jian, Z. R. Li, S. J. Pei, M. H. Qiu, S. X. Qiu. Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells. Beilstein J Organic Chemistry, 2007, 3: 3-8
9. J. Qi, J. J. Chen, Z. H. Cheng, J. H. Zhou, B. Y.Yu, S. X. Qiu. Iridoid glycosides from Harpagophytum procumbens D.C. (Devils’ claw). Phytochemistry, 2006, 67: 1372-1377
10. L. P. Ruan, S. Chen, B. Y. Yu, D. N. Zhu, G. A. Cordell, S. X. Qiu. Prediction of human absorption of natural products by non-everted rat intestinal sac model. European Journal of Medicinal Chemistry, 2006, 41(5): 606-610
11. L. Pan, P. Zhou, X. F. Zhang, S.L. Peng, L. S. Ding, S. X. Qiu. Skeleton-Rearranged pentacyclic diterpenes possessing a cyclobutane ring from Euphorbia wallichii. Organic Letters, 2006, 8(13): 2775-2778
12. Z. H. Cheng, B. Y. Yu, Y. L. Guo, S. X. Qiu. Microbial hydroxylation of quinovic acid glycoside by Streptomyces griseus ACCT 13272. Chinese Journal of Chemistry, 2006, 24(1): 95-98
13. C. Chen, M. H. Chiu, R. L. Nie, G. A. Cordell and S. X. Qiu. Curcurbitacins and cucurbitane glycosides: structures and biological activities. Natural Products Reports, 2005, 22: 386-399
14. Z. Y. Jiang, X. M. Zhang, J. Zhou, S. X. Qiu, J. J. Chen. Two new triterpenoid glycosides from Cyclocarya paliurus. Journal of Asian Natural Products Research, 2005, 8(1-2): 93-98
15. J. Zhang, Z. H. Cheng, B. Y. Yu, G. A. Cordell, S. X. Qiu. Novel Biotransformation of pentacyclic triterpenoid acids by microbe Nocardia sp. NRRL 5646. Tetrahedron Letters, 2005, 46(13): 2337-2340
16. Z. P. J. Lin, S. X. Qiu, L. Shum. Simultaneous determination of glycyrrhizin, a marker component in radix Glycyrrhizae, and its major metabolite glycyrrhetic acid in human plasma by LC-MS/MS. J Chromatography B, 2005, 814: 201-207
17. Z. H. Chen, B. Y. Yu, G. A. Cordell, S. X. Qiu. Biotransformation of quinovic acid glycosides by microbes: Direct conversion of the Ursane to the Oleanane triterpene skeleton by Nocardia sp. NRRL 5646. Organic Letters, 2004, 6(18): 3163-3165
18. S. X. Qiu, R. Z. Yang, M. Gross. Synthesis and LC/Tandem mass spectrometric characterization of the adducts of bisphenol-A (BPA)-O-quinone with glutathione and nucleotide monophosphates. Chem Res Tox, 2004, 17: 1038-1046
19. B. M. Johnson, S. X. Qiu, S. D. Zhang, F. G. Zhang, J. E. Burdette, L. N. Yu, J. L. Bolton, R. B. van Breemen. Identification of novel electrophilic metabolites of Piper methysticum Forst (kava). Chem Res Tox, 2003, 16(6): 733-740
20. J. T. Xie, A. B. Wang, S. Mehendale, J. Wu, H. H. Aung, L. Dey, S. X. Qiu, C. S. Yuan. Anti-diabetic effects of Gymnema yunnanense extract. Pharmacological Research, 2003, 47(4): 323-329