基本情况
骆海明，博士，华中科技大学武汉光电国家研究中心教授, 入选国家高层次人才计划、湖北省百人计划。在Science Advances, PNAS、Clinical Cancer Research、Journal of Nuclear Medicine、Biosensors & Bioelectronics、Theranostics、Journal of Nanobiotechnology等期刊上发表SCI论文20多篇。获得授权美国发明专利1项、欧洲发明专利1项，中国发明专利7项，申请中国发明专利多项。
研究方向
阿尔茨海默病的发病机制与防治;
阿尔茨海默病血浆标志物的超灵敏检测；
体外诊断与检测
肿瘤分子探针与多模态成像
教育经历
华中农业大学 本科 生物学 2003-2007
华中科技大学 博士 生物医学工程 2007-2013
工作经历
华中科技大学武汉光电国家研究中心 教授 2018/04至今
麻省理工学院McGovern脑研究所 研究会员 2016/10 to 2018/03
美国哈佛医学院麻省总医院 博士后 2015/10 to 2018/03
美国威斯康辛大学麦迪逊分校 博士后 2013/10 to 2015/10
学术论文
1. Hu Shun, Zhang Liding, Su Ying, Liang Xiaohan, Yang Jie, Luo Qingming, Luo Haiming*.Sensitive detection of multiple blood biomarkers via immunomagnetic exosomal PCR for the diagnosis of Alzheimer’s disease. Science Advances, 2024, 10(13):eabm3088. (SCI，If=14.136，中科院大类一区)
2. Zhang Liding, Cao Kai, Su Ying, Hu Shun, Liang Xiaohan, Luo Qingming, Luo Haiming*. Colorimetric and surface-enhanced Raman scattering dual-mode magnetic immunosensor for ultrasensitive detection of blood phosphorylated tau in Alzheimer's disease. Biosensor and Bioelectronics, 2023, 222:114935 (SCI，If=12.545，中科院大类一区).
3. Zhang Liding, Su Ying, Liang Xiaohan, Cao Kai, Luo Qingming, Luo Haiming*. Ultrasensitive and point-of-care detection of plasma phosphorylated tau in Alzheimer’s disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assays. Nano Research, 2023;16(5):7459-7469 (SCI，If=10.269，中科院大类一区).
4. Hu Shun, Yang Changwen, Li Yanqing, Luo Qingming, Luo Haiming*. Nanozyme sensor array based on manganese dioxide for the distinction between multiple amyloid β peptides and their dynamic aggregation process. Biosensor and Bioelectronics, 2022,199:113881 (SCI，If=12.545，中科院大类一区).
5. Hu Shun, Yang Changwen, Luo Haiming*. Current trends in blood biomarker detection and imaging for Alzheimer's disease. Biosensor and Bioelectronics, 2022, 210:114278 (SCI，If=12.545，中科院大类一区).
6. Zhang Liding, Cao Kai, Xie Jun, Liang Xiaohan, Gong Hui, Luo Qingming, Luo Haiming. Aβ42 and ROS dual-targeted multifunctional nanocomposite for combination therapy of Alzheimer's disease. Journal of Nanobiotechnology, 2024, 22(1):278. (SCI，If=9.429，中科院大类一区)
7. Liu Ni, Yang Changwen, Liang Xiaohan, Cao Kai, Xie Jun, Luo Qingming, Luo Haiming*. Mesoporous silica nanoparticle-encapsulated Bifidobacterium attenuates brain Aβ burden and 2 / 3 improves olfactory dysfunction of APP/PS1 mice by nasal delivery. Journal of Nanobiotechnology, 2022, 20(1):439 (SCI，If=9.429，中科院大类一区)
8. Liu Ni, Liang Xiaohan, Yang Changwen, Hu Shun, Luo Qingming, Luo Haiming*. Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-β burden via depolymerization and intestinal metabolism. Theranostics, 2022; 12(15): 6646-6664 (SCI，If=12.400，中科院大类一区).
9. Zhang Liding, Du Xuewei, Su Ying, Niu Shiqi, Li Yanqing, Liang Xiaohan, Luo Haiming*. Quantitative assessment of AD markers using naked eyes: point-of-care testing with paper-based lateral flow immunoassay. Journal of Nanobiotechnology, 2021, 19(1):366 (SCI，If=9.429，中科院大类一区).
10. Zhang Liding, Yang Changwen, Li Yanqing, Niu Shiqi, Liang Xiaohan, Zhang Zhihong, Luo Qingming, Luo Haiming*. Dynamic changes in the levels of amyloid-β42 species in the brain and periphery of APP/PS1 mice and their significance for Alzheimer's disease. Frontiers in Molecular Neuroscience, 2021, 14:723317 (SCI，If=6.261，中科院大类二区).
肿瘤分子成像
1. Luo Haiming# , Hernandez Reinier# , Hong Hao, Graves A Stephen, Yang Yunan, Christopher G England, Theuer P Charles, Nickles J Robert, Cai Weibo. Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry. Proceedings of the National Academy of Sciences, 2015, 112(41):12806-11 (SCI，If=12.779，中科院大类一区).
2. Luo Haiming, Christopher G England, Shi Sixiang, Graves A Stephen, Hernandez Reinier, Liu Bai, Theuer P Charles, Wong C Hing, Nickles J Robert, Cai Weibo. Dual Targeting of Tissue Factor and CD105 for Preclinical PET Imaging of Pancreatic Cancer. Clinical Cancer Research, 2016, 22(15):3821-30 (SCI，If=13.801，中科院大类一区).
3. Luo Haiming*, Yang Changwen, Kuang Dong, Chan W. Annie*. Visualizing dynamic changes in PD-L1 expression in non-small-cell lung carcinoma with radiolabeled recombinant human PD1. European Journal of Nuclear Medicine and Molecular Imaging, 2022, 49(8):2735-2745 (SCI， If=10.057，中科院大类一区).
4. Luo Haiming# , Christopher G England# , Graves A Stephen, Sun Haiyan, Liu Glenn, Nickles J Robert, Cai Weibo. PET of VEGFR2 in cancer with 64Cu-labeled ramucirumab. Journal of Nuclear Medicine, 2016, 57(2):285-90 (SCI，If=11.082，中科院大类一区).
5. Luo Haiming, Hong Hao, Slater R Michael, Graves A Stephen, Shi Sixiang, Yang Yunan, Nickles J Robert, Fan Frank, Cai Weibo. PET of c-Met in cancer with 64Cu-labeled Hepatocyte Growth Factor. Journal of Nuclear Medicine, 2015, 56(5):758-63 (SCI，If=11.082，中科院大类一区).
6. Luo Haiming*, Lu Lisen, Liu Ni, Li Qingqing, Yang Xiaoquan, Zhang Zhihong*. Curcumin loaded sub-30 nm targeting therapeutic lipid nanoparticles for synergistically blocking nasopharyngeal cancer growth and metastasis. Journal of Nanobiotechnology, 2021, 19(1):224 (SCI，If=9.429，中科院大类一区).
7. Luo Haiming, England G Christopher, Goel Shreya, Graves A Stephen, Ai Fanrong, Liu Bai, Theuer P Charles, Wong C Hing, Nickles J Robert, Cai Weibo. ImmunoPET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer with a Dual-Labeled Bispecific Antibody Fragment. Molecular Pharmaceutics, 2017, 14(5):1646-1655 (SCI，If=5.364，中科院大类二区).
8. Luo Haiming, Hong Hao, Yang P Sarah, Cai Weibo. Design and Applications of Bispecific Heterodimers: Molecular Imaging and beyond. Molecular Pharmaceutics, 2014, 11(6):1750-61. (SCI，If=11.082，中科院大类一区).
9. Luo Haiming, Lu Lisen, Yang Fei, Wang Liang, Yang Xiaoquan, Luo Qingming, Zhang Zhihong. Nasopharyngeal Cancer-Specific Therapy Based on Fusion Peptide-Functionalized Lipid Nanoparticles. ACS Nano, 2014, 8(5):4334-47. (SCI，If=18.027，中科院大类一区).
10. Luo Haiming# , Shi Jiyun# , Jin Honglin, Fan Di, Lu Lisen, Wang Fan, Zhang Zhihong. An (125)I labeled octavalent peptide fluorescent nanoprobe for tumor-homing imaging in vivo. Biomaterials, 2012, 33(19):4842-50. (SCI，If=15.304，中科院大类一区).
授权专利
1、骆海明；张立定；用于检测人淀粉样蛋白-β双抗夹心ELISA检测试剂盒；20220329，中国，专利号：202011227418.8
2、骆海明；骆清铭；张立定；用于检测人淀粉样蛋白-β的胶体金免疫层析试纸及其制备；20220325，中国，专利号：202110067679.6