基本情况

邢国刚，北京大学神经科学研究所、基础医学院神经生物学系，教授，博士生导师。

研究领域

离子通道与慢性痛的记忆、认知和情绪机制研究；痛与痛觉调制的高级神经网络机制研究；少弱精子症的发病机制与防治措施研究

教育背景

2004年5月至2006年6月 访问学者，美国Burnham医学研究所和威斯康星大学生理系

2001年7月至2003年7月 博士后，北京大学，基础医学院神经生物学系

1998年9月至2001年6月 博士，西安交通大学医学院生理系

1994年9月至1997年7月 硕士，西安医科大学生理系

1984年9月至1989年7月 学士，新乡医学院儿科系

工作经历

2013年8月至今      教授，博士生导师，北京大学基础医学院神经生物学系

2004年8月至2013年7月  副教授，北京大学基础医学院神经生物学系

2003年8月至2004年7月  讲师，北京大学基础医学院神经生物学系

1994年9月至1998年8月  讲师，新乡医学院，生理学教研室

1989年8月至1994年8月  助教，新乡医学院，生理学教研室

论文发表

1. Dong Fang, Ling-Yu Kong, JieCai, Song Li, Hong-Yan Zhao, Xiao-Dan Liu, Ji-Sheng Han, Guo-Gang Xing*. Interleukin-6-mediated functional upregulation ofTRPV1 receptors in dorsal root ganglion neuronsthrough the activation of JAK/PI3K signalingpathway: roles in the development of bone cancerpain in a rat model. Pain. 2015 Apr;156(6): 1124-1144
2. Xing Xiao, Xiao-Tao Zhao, Ling-Chi Xu, Lu-PengYue, Feng-Yu Liu, JieCai, Fei-Fei Liao, Jin-Ge Kong, Guo-Gang Xing, Ming Yi, You Wan. Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats.Pain. 2015 Apr;156(4): 597-608
3. JieCai, Dong Fang, Xiao-Dan Liu, Song Li, Juan Ren and Guo-Gang Xing*. Suppression of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to the sensitization of dorsal horn WDR neurons and pain hypersensitivity in a rat model of bone cancer pain. Oncology Reports. 2015 Mar; 33(3): 1540-1550
4. Xu Ding, JieCai, Song Li, Xiao-Dan Liu, You Wan, Guo-Gang Xing*. BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation. Neurobiology of Disease. 2014; 73C: 428-451
5. Xiao-Dan Liu, Jing-Jing Yang, Dong Fang, JieCai, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Increased functional Nav1.8 on the membrane of dorsal root ganglia contributes to the development of rat bone cancer pain. PLoS One. December 11, 2014, 9(12): e114623. doi:10.1371/journal.pone.0114623
6. Hong Jiang, Ling-Yu Kong, Zi-Run Jin, JieCai, Xue-Jing Kang, You Wan and Guo-Gang Xing*. Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats. Molecular Brain. 2014 Oct 4; 7(1): 72-93
7. Lei Ding,JieCai, Xiang-Yang Guo, Xiu-Li Meng*, Guo-Gang Xing*. The anti-allodynic action of pregabalin may depend on the suppression of spinal neuronal hyperexcitability via decreasing the dorsal horn N-methyl-D-aspartate receptors in rats with spared nerve injury. Pain Research & Management. 2014; 19(4): 205-211
8. Yan Li, JieCai, Yin Han, Xin Xiao, Xiang-Lin Meng, Li Su, Feng-Yu Liu, Guo-Gang Xing, You Wan. Enhanced function of TRPV1 via up-regulation by insulin-like growth factor-1 in a rat model of bone cancer pain.European Journal of Pain. 2014;18(6): 774-84
9. Fei Yang, JiaGuo, Wei-Liang Sun, Feng-Yu Liu, JieCai, Guo-Gang Xing, You Wan. The Induction of Long-Term Potentiation in Spinal Dorsal Horn after Peripheral Nociceptive Stimulation and Contribution of Spinal TRPV1 in Rats.Neuroscience. 2014; 269: 59-66
10. Ling Hu, Xiang-Hong Jing, Cai-Lian Cui, Guo-Gang Xing, Bing Zhu. NMDA receptors in the midbrain play a critical role in dopamine-mediated hippocampal synaptic potentiation caused by morphine. Addiction Biology. 2014;19(3): 380-91
11. Liu X, Zhang B, Yang H, Wang H, Liu Y, Huang A, Liu T, Tian X, Tong Y, Zhou T, Zhang T, Xing GG, Xiao W, Guo X, Fan D, Han X, Liu G, Zhou Z, Chui D. Impaired synaptic vesicle recycling contributes to presynaptic dysfunction in lipoprotein lipase-deficient mice. Neuroscience. 2014 Nov 7; 280: 275-281
12. Min Liu, Huan Yang, Dong Fang, Jing-Jing Yang, JieCai, You Wan, De-Hua Chui, Ji-Sheng Han, Guo-Gang Xing*. Up-regulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 indorsal root ganglion contributes to the bone cancer pain. Pain. 2013; 154(9): 1551-1568
13. Qin Zheng, Dong Fang, Ming Liu, JieCai, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. Pain. 2013; 154(3): 434-448
14. Ya-Nan Wang, Bo Wang, Min Liang, Cai-Yan Han, Bin Zhang, JieCai, Wei Sun*, Guo-Gang Xing*. Down-regulation of CatSper1 channel in epididymal spermatozoa contributes to the pathogenesis of asthenozoospermia, while up-regulation of the channel by Sheng-Jing-San treatment improves the sperm motility of asthenozoospermia in rats. Fertility and Sterility. 2013; 99(2): 579-587
15. Qin Zheng, Dong Fang, JieCai, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Enhanced excitability of small dorsal root ganglion neurons in rats with bone cancer pain. Molecular Pain. 2012; 8(1): 24-41
16. Feng-Yu Liu, Yan-Ni Sun, Fa-Tian Wang, Qian Li, Li Su, Zi-Fang Zhao, Xiang-Ling Meng, Hong Zhao, Xi Wu, Qian Sun, Guo-Gang Xing*, You Wan*. Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation. Brain Research. 2012; 1427: 65-77
17. Yilin Song, Nansen Lin, Chunxiu Liu, Hong Jiang, Guogang Xing, Xinxia Cai. A novel dual mode microelectrode array for neuroelectrical and neurochemical recording in vitro.Biosensors and Bioelectronics. 2012; 38(1): 416-20
18. Ye-Nan Chi, Xu Zhang, JieCai, Feng-Yu Liu, Guo-Gang Xing, You Wan. Formaldehyde increases intracellular calcium concentration in primary cultured hippocampal neurons through NMDA receptors and T-type calcium channels. Neuroscience Bulletin. 2012; 28(6): 715-22
19. Ying Han, Yan Li, Xing Xiao, Jia Liu, Xiang-Ling Meng, Feng-Yu Liu, Guo-Gang Xing, You Wan. Formaldehyde up-regulates TRPV1 through MAPK and PI3K signaling pathways in a rat model of bone cancer pain. Neuroscience Bulletin. 2012; 28(2): 165-72
20. Ying-Ying Wang, Jiong Qin*, Ying Han, JieCai, Guo-Gang Xing*. Hyperthermia induces epileptiform discharges in cultured rat cortical neurons. Brain Research. 2011;1417C: 87-102
21. Ming Yi, Haolin Zhang, Lixing Lao, Guo-Gang Xing, You Wan. Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats. Molecular Pain. 2011; 7(1): 61
22. Jing Wang, Duan Li, Xiaoli Li, Feng-Yu Liu, Guo-Gang Xing, JieCai and You Wan. Phase–amplitude coupling between theta and gamma oscillations during nociception in rat electroencephalography. Neuroscience Letters. 2011; 499(2): 84-87
23. Feng-Yu Liu, Xiao-XiuQu, JieCai, Fa-Tian Wang, Guo-Gang Xing,YouWan. Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation. Neuroscience Bulletin. 2011; 27(1): 1-8
24. Shan-Jing Geng, Fei-Fei Liao, Wen-Hao Dang, Xu Ding, Xiao-Dan Liu, JieCai, Ji-Sheng Han, You Wan, Guo-Gang Xing*. Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation. Experimental Neurology. 2010; 222(2): 256-266
25. Feng-Yu Liu, Xiao-XiuQu, Xu Ding, JieCai, Hong Jiang, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation. Brain Research. 2010; 1330: 45-60
26. Tianran Song, Yue Wang, Guian Chen* and Guogang Xing*. Tyrosine hydroxylase- positive cells and dopaminergic neuronal function in human embryonic stem cells: An electrophysiological validation. Neural Regeneration Research. 2010; 5(3): 185-190
27. Xiao-XiuQu, JieCai, Ming-Jia Li, Ye-Nan Chi, Fei-Fei Liao, Feng-Yu Liu, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain. Experimental Neurology. 2009; 215(2): 298-307
28. Lu Yu, Fei Yang, HaoLuo, Feng-Yu Liu, Ji-Sheng Han, Guo-Gang Xing* and You Wan*. The role of TRPV1 indifferent subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant. Molecular Pain. 2008;4(1): 61-70
29. Yu-Qiu Jiang, Guo-Gang Xing, Sheng-Lan Wang, Hui-Yin Tu, Ye-Nan Chi, Jie Li, Feng-Yu Liu, Ji-Sheng Han, You Wan. Axonal accumulation of hyperpolarization- activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat. Pain. 2008; 137: 495-506
30. Yue Lu, Yan-Ni Sun, Xi Wu, Qian Sun, Feng-Yu Liu, Guo-Gang Xing, You Wan. Role of alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR1 inspinal dorsal horn in inflammatory nociception and neuropathic nociception in rat. Brain Research. 2008;1200C:19-26
31. Hao Luo,Isabella Shi Xu,Yi Chen, Fei Yang, Lu Yu, Guang-Xin Li, Feng-Yu Liu, Guo-Gang Xing, Yu-Shun Shi, Tan Li, Ji-Sheng Han and You Wan. Behavioral and Electrophysiological Evidence for the Differential Functions of TRPV1 at Early and Late Stages of Chronic Inflammatory Nociception in Rats. Neurochemical Research. 2008; 33(10):2151-8
32. Guo-Gang Xing*, Feng-Yu Liu, Xiao-XiuQu, Ji-Sheng Han, You Wan. Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain. Experimental Neurology. 2007; 208(2):323-332
33. Feng-Yu Liu†, Guo-Gang Xing† (co-FA), Xiao-XiuQu, Isabella S. Xu, Ji-Sheng Han, You Wan. Roles of 5-HT receptor subtypes in the inhibitory effects of 5-HT on C-fiber responses of spinal wide dynamic range neurons in rats. The Journal of Pharmacology and Experimental Therapeutics. 2007; 321(3): 1046-1053
34. Guo-Gang Xing†,Rengang Wang†, Bo Yang, Dongxian Zhang. Postnatal switching of NMDA receptor subunits from NR2B to NR2Ain rat facial motor neurons. European Journal of Neuroscience. 2006; 24(11): 2987-2992
35. Qian Sun†, Guogang Xing† (co-FA), HuiyinTu, Ji-Sheng Han, You Wan. Inhibition of hyperpolarization- activated current by ZD7288 suppresses ectopic discharges of injured dorsal root ganglion neurons in a rat model of neuropathic pain. Brain Research. 2005; 1032(1-2): 63-9
36. Qian Sun, HuiyinTu, Guogang Xing, Ji-Sheng Han, You Wan. Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation. Experimental Neurology. 2005; 191(1): 128-36