基本情况

李孟森，海南医学院教授、博士生导师。海南省肿瘤发生和干预重点实验室主任，海南医学院基础医学与生命科学学院副院长，海南医学院分子生物学重点实验室主任；国家级百千万人才，国家有突出贡献中青年专家，国务院特殊津贴专家，全国优秀科技工作者，海南省有突出贡献优秀专家，海南省“515人才工程”第一层次人才，“教育部新世纪优秀人才支持计划”获得者；2010年全国优秀教育工作者，中华医学会医学细胞生物学分会青年委员。

 

研究领域

甲胎蛋白受体的分子结构及其介导的信号转导机制研究、肝癌细胞内甲胎蛋白与PTEN相互作用的生物学意义等

 

教育背景

2008年7月 博士，北京大学基础医学院生物化学与分子生物系

2000年7月 硕士，北京医科大学生物化学与分子生物系

1993年7月 学士，北京医科大基础医学系

 

论文发表

  1. Zhu M, Guo J, Li W, Lu Y, Fu S, Xie X, Xia H, Dong X, Chen Y, Quan M, Zheng S, Xie K, Li M. Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells. Oncotarget, 2015, 6(14): 12196-12208. (SCI; 2014-IF: 6.359)
  2. Zhu M, Guo J, Xia H, Li W, Lu Y, Dong X, Chen Y, Xie X, Fu S, Li M. Alpha fetoprotein activates AKT/mTOR signal to stimulate expression of CXCR4 and migration of hepatoma cells. Oncoscience, 2015, 2(1): 62-73.
  3. Zhu M, Guo J, Li W, Xia H, Lu Y, Dong X, Chen Y, Xie X, Fu S, Li M. HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expression of Src in liver cells and hepatoma cells. BMC Cancer, 2015, 15: 362. (SCI; 2014-IF: 3.362)
  4. Zhu M, Lin B, Zhou P, Li M. Molecular analysis of AFP and HSA interactions with PTEN protein. BioMed Research International, 2015; 2015：256916. (SCI; 2014-IF: 1.579)
  5. Li M , Zhu M, Li W, Lu Y, Xie X, Wu Y, Zheng S. Alpha-fetoprotein receptor as an early indicator of HBx-driven hepatocarcinogenesis and its applications in tracing cancer cell metastasis. Cancer Letters, 2013, 330(2): 170-180. (SCI; 2014-IF: 5.621)
  6. Mengsen Li, Hui Li, Chaoying Li, Shanshan Wang, Wei Jiang, Sheng Zhou, Xinhua Liu, Michael A McNutt, Gang Li. Alpha-fetoprotein, a new member of intracellular signal molecules in regulation of the PI3K/AKT signaling in human hepatoma cells lines. International Journal of Cancer, 2011, 128(3): 524-532. (SCI; IF: 5.008)
  7. Mengsen Li, Mingyue Zhu, Sheng Zhou, Shigan Fu, Xieju Xie, Gang Li. Alpha-fetoprotein up-regulated the expression of c-Src in hepatoma cells is PTEN/AKT signaling pathway dependent or independent. Journal of Clinical Oncology, 2010, 28(15 suppl): e21061. (SCI, ISTP, IF: 17.157)
  8. Li M, Zhu M, Zhou S, Li G. Alpha fetoprotein promotes the expression of CXCR4 via inhiibiting the activity of PTEN. Journal of Hepatology, 2010, 52(suppl 1): S224-S225. (SCI, ISTP, IF: 7.818)