基本情况

王久存，复旦大学生命科学学院教授，现任生命科学学院人类遗传学与人类学系系主任，附属华山医院双聘教授，皮肤表型组学研究联合实验室共同主任，复旦大学风湿免疫过敏性疾病研究中心副主任；中国医学科学院皮肤及皮肤病群体遗传学和防控新技术研究创新单元共同主任；上海人类学学会会长，中国遗传学会理事；联合发起硬皮病临床与研究国际协作网（InSCAR）并任副理事长。任Laboratory Investigation、Journal of Scleroderma and Related Disorders等杂志编委。

研究领域

肺癌致病机理的遗传学及表观遗传学研究、雄性激素不敏感综合征的遗传学研究

教育经历

1999年12月 博士，日本国立福井大学

1991年7月  硕士，复旦大学生命科学学院

1988年7月  学士，复旦大学

论文发表

1. Peng, Qianqian,Liu, Xinxuan,Li, Wenran, et al.Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits[J].NATURE GENETICS,2024,56(05):1032-1033.DOI:10.1038/s41588-023-01494-9.

2. He, Di,Liu, Yining,Dong, Siqi, et al.The prognostic value of systematic genetic screening in amyotrophic lateral sclerosis patients[J].JOURNAL OF NEUROLOGY,2024,271(03):1385-1396.DOI:10.1007/s00415-023-12079-1.

3. Liu, Zhengjiang,Jia, Jinqiao,Lei, Qi, et al.Electrohydrodynamic Direct-Writing Micro/Nanofibrous Architectures: Principle, Materials, and Biomedical Applications[J].ADVANCED HEALTHCARE MATERIALS,2024,13(28).DOI:10.1002/adhm.202400930.

4. Kong, Xiangzhen,Jiang, Shuai,He, Qiuyu, et al.TLR8 aggravates skin inflammation and fibrosis by activating skin fibroblasts in systemic sclerosis[J].RHEUMATOLOGY,2024,63(06):1710-1719.DOI:10.1093/rheumatology/kead456.

5. Liang, Minrui,Wang, Lingbiao,Tian, Xiaolong, et al.Identification and validation of anti-protein arginine methyltransferase 5 (PRMT5) antibody as a novel biomarker for systemic sclerosis (SSc)[J].ANNALS OF THE RHEUMATIC DISEASES,2024,83(09):1144-1155.DOI:10.1136/ard-2024-225596.

6. Zhu, Xingyu,Han, Ruomei,Tian, Xiaoxue, et al.The opposite effect of tapinarof between IMQ and IL-23 induced psoriasis mouse models[J].EXPERIMENTAL DERMATOLOGY,2024,33(01).DOI:10.1111/exd.14862.

7. Tang, Chang,Wang, Lanting,Liu, Qingmei, et al.Pulmonary interstitial lesions in pemphigus mouse model: Verifying pemphigus may not be only limited to skin and mucosa[J].EXPERIMENTAL DERMATOLOGY,2024,33(07).DOI:10.1111/exd.15136.

8. Zheng, HongXiang,Yan, Shi,Zhang, Menghan, et al.Mitochondrial DNA Genomes Reveal Relaxed Purifying Selection During Human Population Expansion after the Last Glacial Maximum[J].MOLECULAR BIOLOGY AND EVOLUTION,2024,41(09).DOI:10.1093/molbev/msae175.

9. Zhang, Rui,Pu, Weilin,Zhang, Xinyuan, et al.Blue light protection factor: a method to assess the protective efficacy of cosmetics against blue light-induced skin damage in the Chinese population[J].PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES,2024,23(04):711-718.DOI:10.1007/s43630-024-00546-1.

10. Chen, Wenyan,Li, Jinxi,Xu, Ke, et al.Genetic Variants Associated with Sweat Gland in 6210 Han Chinese Individuals[J].JOURNAL OF INVESTIGATIVE DERMATOLOGY,2024,144(09).DOI:10.1016/j.jid.2024.02.037.

11. He, Di,He, Xinyi,Shen, Dongchao, et al.Loss-of-function variants in RNA binding motif protein X-linked induce neuronal defects contributing to amyotrophic lateral sclerosis pathogenesis[J].MEDCOMM,2024,5(09).DOI:10.1002/mco2.712.

12. Wang, Jingjie,Zhang, Yitong,Ma, Yanyun, et al.TET1 inhibits liver fibrosis by blocking hepatic stellate cell activation[J].JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2024,39(07):1403-1412.DOI:10.1111/jgh.16443.

13. Shi, Xiangguang,Chen, Yahui,Shi, Mengkun, et al.The novel molecular mechanism of pulmonary fibrosis: insight into lipid metabolism from reanalysis of single-cell RNA-seq databases[J].LIPIDS IN HEALTH AND DISEASE,2024,23(01).DOI:10.1186/s12944-024-02062-8.

14. Zheng, Yuanting,Liu, Yaqing,Yang, Jingcheng, et al.Multi-omics data integration using ratio-based quantitative profiling with Quartet reference materials[J].NATURE BIOTECHNOLOGY,2024,42(07).DOI:10.1038/s41587-023-01934-1.

15. Tang, Yulong,Zhuo, Dachun,Yu, Yuexin, et al.Single-cell RNA sequencing reveals the CRTAC1⁺ population actively contributes to the pathogenesis of spinal ligament degeneration by SPP1⁺ macrophage[J].AGING CELL,2024,23(12).DOI:10.1111/acel.14320.

16. Huang Y, Zhao H, Zhang Y, Tang Y, Shi X, Jiang S, Pu W, Liu J, Ma Y, Lin J, Lin J, Wu W, Gong Y*, Wang J*, Liu Q*. Enhancement of zyxin promotes skin fibrosis by regulating FAK/PI3K/AKT and TGF-β signaling pathways via integrins. International Journal of Biological Sciences. 2023 Apr 29;19(8):2394-2408.

17. Ma Y, Tan Yimei, Hu Y, Pu W, Xu J, Jin L*, Wang J*. Quantitative assessment of ultraviolet-induced erythema and tanning responses in the Han Chinese population, Phenomics, 2023.

18. Yi Li, Meng Hao, Zixin Hu, Yanyun Ma, Kun Wang, Xiaoyu Liu, …, Longli Kang, Wenyuan Duan, Bin Qiao, Wang J*, Li Jin*, The composite phenotype analysis identifies potential concerted responses of physiological systems to high altitude exposure, National Science Review, Volume 10, Issue 5, May 2023, nwad053, https://doi.org/10.1093/nsr/nwad053

19. Liu J, Huang Y, Gong Y, Liu Q, Lin J, Liu J, Liu M, Huang J, Pu W, Ma Y, Zhang Y, Li H, Shi X, Zhang Y, Wang J, Zhu Y, Wang Q, Wei K, Wang J, Sha Y, Wang J*, Wu W*. CTHRC1+ fibroblasts are stimulated by macrophage-secreted SPP1 to induce excessive collagen deposition in keloids. Clinical and Translational Medicine. 2022 Dec;12(12):e1115.

20. Shi X, Chen Y, Liu Q, Mei X, Liu J, …, Zou H, Zhao S, Distler JHW, Jin L, Wang J*. LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis. Clinical and Translational Medicine. 2022 Jan;12(1):e711. doi: 10.1002/ctm2.711. PMID: 35083881.

21. Pu W, Zhang R, Ma Y, Liu Q, Jiang S, Liu J, Zhao Y, Tu W, Guo G, Zuo X, Wang Q, Chen Y, Wu W, Zhou X, Distler JHW, Reveille JD, Zou H, Jin L, Mayes MD, Wang J*. Genetic associations of non-major histocompatibility complex susceptibility loci with systemic sclerosis in a Han Chinese population. Journal of Investigative Dermatology2022 Jul;142(7):2039-2042.e7.