基本情况

梁淑芳，女，四川大学生物治疗国家重点实验室教授、博士生导师。入选教育部新世纪优秀人才，四川省学术和技术带头人, 四川省卫生健康委员会学术技术带头人。担任科技部重点专项评审专家，国家自然科学基金评审专家，四川省科技项目评审专家，成都市科技项目评审/评估专家。任Scientific Reports、Protein & Peptide Letters等SCI杂志编委。

研究领域

现主要从事蛋白质组学、基因功能研究及肿瘤的发病机理与生物技术药物研发等研究

教育背景

2003年 四川大学 博士

2003年-2005年 复旦大学化学系/蛋白质组研究中心 博士后

2014年 美国J Craig Venter Institute研究所 高级访问学者

工作经历

2005年 四川大学生物治疗国家重点实验室 副教授、硕士生导师

2010年-至今 四川大学生物治疗国家重点实验室 教授、博士生导师

科研项目

近年已主持承担国家自然基金多项、863课题、973子课题、教育部“新世纪优秀人才支持计划”、教育部博士点基金、四川省杰出青年基金、四川省科技支撑计划等课题。以第一/通讯作者发表60多篇SCI论文，获得授权发明专利6项。

论文发表

1. Zenghua Sheng, Shu Luo, Lan Huang, Ya-nan Deng, Nan Zhang, Yinheng Luo, Xinyu Zhao, Ying Chen, Qiu Li, Ruiwu Dai, Shufang Liang*. SENP1-mediated deSUMOylation of YBX1 promotes colorectal cancer development through the SENP1-YBX1-AKT signaling axis. Oncogene 2025, DOI:10.1038/s41388-025-03302-6

2. Ya-nan Deng, Lan Huang, Shan Gao, Zenghua Sheng, Yinheng Luo, Nan Zhang, Samina Ejaz Syed, Ruiwu Dai, Qiu Li, Xianghui Fu, Shufang Liang*. The SUMOylated RREB1 interacts with KDM1A to induce 5-fluorouracil resistance via upregulating thymidylate synthase and activating DNA damage response pathway in colorectal cancer. MedComm, 2025, 6(3):e70105

3. Xinpeng Liu , Lan Huang, Yang Ye, Haiyi Wang , Min Tang, Fuqiang He, Zijing Xia , Shi Deng, Peng Zhang, Ruiwu Dai, Shufang Liang *. Staphylococcus aureus nt5 gene mutation through CRISPR RNA-guided base editing weakens bacterial virulence and immune evasion. Virulence 2025, 16(1), 2451163

4. Fuqiang He, Xinpeng Liu, Haiyi Wang, Xu Li, Yun Wu, Dan Zhang, Shufang Liang *.The transcriptional regulator DhyR positively modulates daptomycin biosynthesis in Streptomyces roseosporus. Microb. Biotechnol. 2025, 18(3):e70110

5. Fuqiang He, Xinpeng Liu, Min Tang, Haiyi Wang, Yun Wu, Shufang Liang*. CRISETR: an efficient technology for multiplexed refactoring of biosynthetic gene clusters. Nucleic Acids Res 2024, 52, 11378–11393

6. Yanfang Yang, Lan Huang, Nan Zhang, Ya-Nan Deng, Xu Cao, Yue Liang, Huijin Hou, Yinheng Luo, Yang Yang,Qiu Li, Shufang Liang*. SUMOylation of annexin A6 retards cell migration and tumor growth by suppressing RHOU/AKT1–involved EMT in hepatocellular carcinoma. Cell Commun. Signal.,2024,22:206

7. Yu He, Yinheng Luo, Lan Huang, Dan Zhang, Huijin Hou, Yue Liang, Shi Deng, Peng Zhang, Shufang Liang*. Novel inhibitors targeting the PGK1 metabolic enzyme in glycolysis exhibit effective antitumor activity against kidney renal clear cell carcinoma in vitro and in vivo. Eur. J. Med. Chem., 2024,267:116209

8. Zenghua Sheng, Xu Cao, Ya-nan Deng, Xinyu Zhao, Shufang Liang*. SUMOylation of AnxA6 facilitates EGFR-PKCα complex formation to suppress epithelial cancer growth. Cell Commun. Signal., 2023, 21:189

9. Yu He, Xixi Wang, Weiliang Lu, Dan Zhang, Lan Huang, Yang Luo, Li Xiong, Haocheng Li, Peng Zhang, Qiu Li, Shufang Liang*. PGK1 contributes to tumorigenesis and sorafenib resistance of renal clear cell carcinoma via activating CXCR4/ERK signaling pathway and accelerating glycolysis. Cell Death & Dis., 2022,13:118

10. Bing Chen, Ya-nan Deng, Xixi Wang, Zijing Xia, Yu He, Peng Zhang, Samina Ejaz Syed, Qiu Li*, Shufang Liang*. miR-26a enhances colorectal cancer cell growth by targeting RREB1 deacetylation to activate AKT-mediated glycolysis. Cancer Lett., 2021, 521: 1-13

11. Dan Zhang, Xixi Wang, Yang Ye, Yu He, Fuqiang He, Yongqiang Tian, Yunzi Luo*, Shufang Liang*. Label-free proteomic dissection on dptP-deletion mutant uncovers dptP involvement in strain growth and daptomycin tolerance of Streptomyces roseosporus. Microb. Biotechnol., 2021, 14(2), 708-725

12. Jun Zhang, Dan Zhang, Jie Zhu, Huayi Liu, Shufang Liang*, Yunzi Luo*. Efficient multiplex genome editing in Strepotomyces via engineered CRISPR-Cas12a systems.Front. Bioeng. Biotechnol. , 2020,8:726

13. Yanfang Yang, Ziwei Liang, Zijing Xia, Xixi Wang, Yanni Ma, Zenghua Sheng, Qingjia Gu, Guobo Shen, Liangxue Zhou, Hongxia Zhu, Ningzhi Xu, Shufang Liang*. SAE1 promotes human glioma progression through activating AKT SUMOylation-mediated signaling pathways.Cell Commun. Signal.,2019,17:82

14. Ziwei Liang, Yanfang Yang, Yu He, Pengbo Yang, Xixi Wang, Gu He, Peng Zhang, Hongxia Zhu, Ningzhi Xu, Xia Zhao, Shufang Liang*. SUMOylation of IQGAP1 promotes the development of colorectal cancer. Cancer Lett., 2017, 411:90-99